Results 171 to 180 of about 11,132 (198)

ABCA1, ABCG1, and Cholesterol Homeostasis

2022
Cholesterol is a major component of mammalian cell membranes and plays important structural and functional roles. However, excessive cholesterol accumulation is toxic to cells and constitutes the molecular basis for many diseases, especially atherosclerotic cardiovascular disease.
Xiao-Hua, Yu, Chao-Ke, Tang
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Macrophage ABCG1 Deletion Disrupts Lipid Homeostasis in Alveolar Macrophages and Moderately Influences Atherosclerotic Lesion Development in LDL Receptor-Deficient Mice

Arteriosclerosis, Thrombosis, and Vascular Biology, 2006
Objective - ABCG1 has recently been identified as a facilitator of cellular cholesterol and phospholipid efflux to high-density lipoprotein (HDL). Its expression in macrophages is induced during cholesterol uptake in macrophages and by liver X receptor ...
Menno Hoekstra, Theo van Berkel, Folkert Kuipers   +2 more
exaly   +2 more sources

Recent advances in the regulation of ABCA1 and ABCG1 by lncRNAs

Clinica Chimica Acta, 2021
Coronary heart disease (CHD) with atherosclerosis is the leading cause of death worldwide. ABCA1 and ABCG1 promote cholesterol efflux to suppress foam cell generation and reduce atherosclerosis development. Long noncoding RNAs (lncRNAs) are emerging as a unique group of RNA transcripts that longer than 200 nucleotides and have no protein-coding ...
Shun Zhang, Lu Li, Jie Wang, Tingting Zhang, Ting Ye, Shuai Wang, Dongming Xing, Wujun Chen   +7 more
openaire   +2 more sources

ABCG1 is involved in vitamin E efflux

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014
Vitamin E membrane transport has been shown to involve the cholesterol transporters SR-BI, ABCA1 and NPC1L1. Our aim was to investigate the possible participation of another cholesterol transporter in cellular vitamin E efflux: ABCG1. In Abcgl-deficient mice, vitamin E concentration was reduced in plasma lipoproteins whereas most tissues displayed a ...
Olivier, Maryline, Bott, Romain, Frisdal, Eric, Nowicki, Marion, Plengpanich, Wanee, Desmarchelier, Charles, Roi, Stéphanie, Quinn, Carmel M., Gelissen, Ingrid, Jessup, Wendy, van Eck, Miranda, Guérin, Maryse, Le Goff, Wilfried, Reboul, Emmanuelle   +13 more
openaire   +4 more sources

ABCG1 – A potential therapeutic target for atherosclerosis

Medical Hypotheses, 2007
Cholesterol efflux from macrophage foam cells, the initial step of reverse cholesterol transport, is assumed to be the most relevant step with respect to atherosclerosis. As one of the ATP-binding cassette transporter (ABC) family members, ABCG1 plays a critical role in the process of cholesterol efflux.
Zhan-ling, Ni, Shui-ping, Zhao, Zhihong, Wu   +2 more
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Total Body ABCG1 Expression Protects Against Early Atherosclerotic Lesion Development in Mice

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Objective - ABCG1 has recently been identified as a facilitator of cholesterol and phospholipid efflux from macrophages to HDL. In bone marrow transplantation studies, we and others have now shown that the absence of macrophage ABCG1 may differentially ...
Johan Kuiper, Menno Hoekstra, Theo van Berkel   +2 more
exaly   +2 more sources

Physiological function of ABCG1

Drug News & Perspectives, 2003
Since ATP-binding cassette transporter A1 (ABCA1) was discovered as the cause of Tangier disease and familial high-density lipoprotein (HDL) deficiency, many investigators have been interested in the relationship between ABC transporters and the mechanism underlying abnormal lipid metabolism.
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Species variation in ABCG1 isoform expression: Implications for the use of animal models in elucidating ABCG1 function

Atherosclerosis, 2013
The ATP-binding cassette transporter G1 (ABCG1) plays an important role in reverse cholesterol transport by exporting cholesterol to high density lipoproteins (HDL). Two major ABCG1 isoforms exist in humans, which differ by the presence or absence of twelve amino acids between the ATP cassette and the transmembrane domains.
Vicky, Burns, Laura J, Sharpe, Ingrid C, Gelissen, Andrew J, Brown   +3 more
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Expanding roles of ABCG1 and sterol transport

Current Opinion in Lipidology, 2013
To offer a comprehensive review on the role of ABCG1 in cellular sterol homeostasis.Early studies with Abcg1 mice indicated that ABCG1 was crucial for tissue lipid homeostasis, especially in the lung. More recent studies have demonstrated that loss of ABCG1 has wide-ranging consequences and impacts lymphocyte and stem cell proliferation, endothelial ...
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Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014
ATP-binding cassette transporter G1 (ABCG1) plays an important role in macrophage reverse cholesterol transport in vivo by promoting cholesterol efflux onto lipidated apoA-I. However, the underlying mechanism is unclear. Here, we found that ABCG1 co-immunoprecipitated with caveolin-1 (CAV1) but not with flotillin-1 and -2.
Hong-Mei, Gu, Fa-Qi, Wang, Da-Wei, Zhang
openaire   +2 more sources