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Structure and transport mechanism of the human cholesterol transporter ABCG1 [PDF]

Cell Reports, 2022
The reverse cholesterol transport pathway is responsible for the maintenance of human cholesterol homeostasis, an imbalance of which usually leads to atherosclerosis. As a key component of this pathway, the ATP-binding cassette transporter ABCG1 forwards cellular cholesterol to the extracellular acceptor nascent high-density lipoprotein (HDL). Here, we
Da Xu, Yanyan Li, Xuebiao Yao
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ABCG1 – A potential therapeutic target for atherosclerosis

Medical Hypotheses, 2007
Cholesterol efflux from macrophage foam cells, the initial step of reverse cholesterol transport, is assumed to be the most relevant step with respect to atherosclerosis. As one of the ATP-binding cassette transporter (ABC) family members, ABCG1 plays a critical role in the process of cholesterol efflux.
Zhan-ling, Ni, Shui-ping, Zhao, Zhihong, Wu   +2 more
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ABCG1 is involved in vitamin E efflux

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014
Vitamin E membrane transport has been shown to involve the cholesterol transporters SR-BI, ABCA1 and NPC1L1. Our aim was to investigate the possible participation of another cholesterol transporter in cellular vitamin E efflux: ABCG1. In Abcgl-deficient mice, vitamin E concentration was reduced in plasma lipoproteins whereas most tissues displayed a ...
Olivier, Maryline, Bott, Romain, Frisdal, Eric, Nowicki, Marion, Plengpanich, Wanee, Desmarchelier, Charles, Roi, Stéphanie, Quinn, Carmel M., Gelissen, Ingrid, Jessup, Wendy, van Eck, Miranda, Guérin, Maryse, Le Goff, Wilfried, Reboul, Emmanuelle   +13 more
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Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014
ATP-binding cassette transporter G1 (ABCG1) plays an important role in macrophage reverse cholesterol transport in vivo by promoting cholesterol efflux onto lipidated apoA-I. However, the underlying mechanism is unclear. Here, we found that ABCG1 co-immunoprecipitated with caveolin-1 (CAV1) but not with flotillin-1 and -2.
Hong-Mei, Gu, Fa-Qi, Wang, Da-Wei, Zhang
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Physiological function of ABCG1

Drug News & Perspectives, 2003
Since ATP-binding cassette transporter A1 (ABCA1) was discovered as the cause of Tangier disease and familial high-density lipoprotein (HDL) deficiency, many investigators have been interested in the relationship between ABC transporters and the mechanism underlying abnormal lipid metabolism.
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Species variation in ABCG1 isoform expression: Implications for the use of animal models in elucidating ABCG1 function

Atherosclerosis, 2013
The ATP-binding cassette transporter G1 (ABCG1) plays an important role in reverse cholesterol transport by exporting cholesterol to high density lipoproteins (HDL). Two major ABCG1 isoforms exist in humans, which differ by the presence or absence of twelve amino acids between the ATP cassette and the transmembrane domains.
Vicky, Burns, Laura J, Sharpe, Ingrid C, Gelissen, Andrew J, Brown   +3 more
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Expanding roles of ABCG1 and sterol transport

Current Opinion in Lipidology, 2013
To offer a comprehensive review on the role of ABCG1 in cellular sterol homeostasis.Early studies with Abcg1 mice indicated that ABCG1 was crucial for tissue lipid homeostasis, especially in the lung. More recent studies have demonstrated that loss of ABCG1 has wide-ranging consequences and impacts lymphocyte and stem cell proliferation, endothelial ...
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ABCG1 mediated oxidized LDL-derived oxysterol efflux from macrophages

Biochemical and Biophysical Research Communications, 2009
The uptake of oxidized LDL (oxLDL) by macrophages is a key initial event in atherogenesis, and the removal of oxidized lipids from artery wall via reverse cholesterol transport is considered antiatherogenic. The aims of this study were to investigate the pathways mediating the removal of oxysterols from oxLDL-loaded macrophages, and the subsequent ...
Zhou, H, Wong, Y, Shiu, SWM, Guo, R, Tan, KCB, Xu, M   +5 more
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Genomic Sequence and Structure of the Human ABCG1 (ABC8) Gene

Biochemical and Biophysical Research Communications, 2001
The human ATP-binding cassette half transporter G1 (hABCG1) may play a role in cholesterol transport in macrophages. Using RACE assays we determined the structure of this gene. The hABCG1 gene spans more than 97 kb comprising 20 exons, 20 kb and 5 exons more than hitherto described. Four of the novel exons are upstream and one is downstream of previous
S, Lorkowski, S, Rust, T, Engel, E, Jung, K, Tegelkamp, E A, Galinski, G, Assmann, P, Cullen   +7 more
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ABCG1 and Pgp identify drug resistant, self-renewing osteosarcoma cells

Cancer Letters, 2019
Patients with osteosarcoma (OST) frequently relapse with drug resistant disease, consistent with the hypothesis that tumours contain a cancer stem-like cell (CSCs) population that survives chemotherapy to re-populate the tumour at local or metastatic sites.
Elizabeth Ann, Roundhill, Sara, Jabri, Susan Ann, Burchill   +2 more
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