A Novel Humanized Anti-Abrin A Chain Antibody Inhibits Abrin Toxicity In Vitro and In Vivo [PDF]
Frontiers in Immunology, 2022 Abrin, a type-II ribosome inactivating protein from the seed of Abrus precatorius, is classified as a Category B bioterrorism warfare agent. Due to its high toxicity, ingestion by animals or humans will lead to death from multiple organ failure ...
Jingyi Peng +15 more
doaj +5 more sources
A Case of Poisoning with Abrus precatarius Complicated with Bilateral Basal Ganglia Haemorrhage [PDF]
Case Reports in Neurological Medicine, 2022 Abrus precatarius is a tropical climber, whose seeds contain abrin, which is known to cause toxicity in humans. We report a case of a young girl, who presented with haemorrhagic enterocolitis, bilateral septal vein thrombosis, and basal ganglia ...
Arun Rajaratnam +3 more
doaj +3 more sources
Neutralizing Monoclonal Antibody, mAb 10D8, Is an Effective Detoxicant against Abrin-a Both In Vitro and In Vivo [PDF]
Toxins, 2022 Abrin is a types II ribosome-inactivating protein (RIP) isolated from Abrus precatorious seeds, which comprises a catalytically active A chain and a lectin-like B chain linked by a disulfide bond.
Zhi Li +8 more
doaj +2 more sources
Characterization of Lung Injury following Abrin Pulmonary Intoxication in Mice: Comparison to Ricin Poisoning [PDF]
Toxins, 2022 Abrin is a highly toxic protein obtained from the seeds of the rosary pea plant Abrus precatorius, and it is closely related to ricin in terms of its structure and chemical properties.
Anita Sapoznikov +6 more
doaj +2 more sources
Rapid Differential Detection of Abrin Isoforms by an Acetonitrile- and Ultrasound-Assisted On-Bead Trypsin Digestion Coupled with LC-MS/MS Analysis [PDF]
Toxins, 2021 The high toxic abrin from the plant Abrus precatorius is a type II ribosome-inactivating protein toxin with a human lethal dose of 0.1–1.0 µg/kg body weight.
Long-Hui Liang +6 more
doaj +2 more sources
Differentiation, Quantification and Identification of Abrin and Abrus precatorius Agglutinin [PDF]
Toxins, 2021 Abrin, the toxic lectin from the rosary pea plant Abrus precatorius, has gained considerable interest in the recent past due to its potential malevolent use.
Sylvia Worbs +9 more
doaj +2 more sources
N-Glycosylation Profile of Abrin Certified EU Reference Material [PDF]
ToxinsAbrin is a highly toxic plant protein encompassing four isoforms, abrin-a, -b, -c and -d. An abrin reference material was isolated from Abrus precatorius and certified (EURM-113) by the EuroBioTox consortium.
Roland Josuran +6 more
doaj +2 more sources
Development and Evaluation of an Immuno-MALDI-TOF Mass Spectrometry Approach for Quantification of the Abrin Toxin in Complex Food Matrices [PDF]
Toxins, 2021 The toxin abrin found in the seeds of Abrus precatorius has attracted much attention regarding criminal and terroristic misuse over the past decade. Progress in analytical methods for a rapid and unambiguous identification of low abrin concentrations in ...
Sandrine Livet +7 more
doaj +2 more sources
Abrin Toxin Paradoxically Increases Protein Synthesis in Stimulated CD4+ T-Cells While Decreasing Protein Synthesis in Kidney Cells [PDF]
Current Issues in Molecular BiologyAbrin, a toxin of the rosary pea plant (Abras precatorius), has been implicated as causing an autoimmune demyelinating disease in humans, but the exact mechanisms responsible for the induction of these demyelinating conditions are still unknown.
Bradley Hernlem, Reuven Rasooly
doaj +2 more sources
Sensitive Detection and Differentiation of Biologically Active Ricin and Abrin in Complex Matrices via Specific Neutralizing Antibody-Based Cytotoxicity Assay [PDF]
ToxinsRicin and abrin are highly potent plant-derived toxins, categorized as type II ribosome-inactivating proteins. High toxicity, accessibility, and the lack of effective countermeasures make them potential agents in bioterrorism and biowarfare, posing ...
Zhi Li +6 more
doaj +2 more sources