Differentiation, Quantification and Identification of Abrin and Abrus precatorius Agglutinin [PDF]
Toxins, 2021 Abrin, the toxic lectin from the rosary pea plant Abrus precatorius, has gained considerable interest in the recent past due to its potential malevolent use.
Sylvia Worbs +9 more
doaj +9 more sources
Mapping Immunodominant Antibody Epitopes of Abrin [PDF]
Antibodies, 2020 Abrin, a toxin isolated from the seeds of Abrus precatorius (jequirity pea) is considered a biological threat agent by the Center for Disease Control and Prevention.
Ron Alcalay +6 more
doaj +7 more sources
A Novel Humanized Anti-Abrin A Chain Antibody Inhibits Abrin Toxicity In Vitro and In Vivo [PDF]
Frontiers in Immunology, 2022 Abrin, a type-II ribosome inactivating protein from the seed of Abrus precatorius, is classified as a Category B bioterrorism warfare agent. Due to its high toxicity, ingestion by animals or humans will lead to death from multiple organ failure ...
Jingyi Peng +15 more
doaj +5 more sources
A Glycoprotein-Based Surface-Enhanced Raman Spectroscopy–Lateral Flow Assay Method for Abrin and Ricin Detection [PDF]
ToxinsAbrin and ricin, both type II ribosome-inactivating proteins, are toxins of significant concern and are under international restriction by the Chemical Weapons Convention and the Biological and Toxin Weapons Convention.
Lan Xiao +8 more
doaj +4 more sources
Neutralizing Monoclonal Antibody, mAb 10D8, Is an Effective Detoxicant against Abrin-a Both In Vitro and In Vivo [PDF]
Toxins, 2022 Abrin is a types II ribosome-inactivating protein (RIP) isolated from Abrus precatorious seeds, which comprises a catalytically active A chain and a lectin-like B chain linked by a disulfide bond.
Zhi Li +8 more
doaj +4 more sources
N-Glycosylation Profile of Abrin Certified EU Reference Material [PDF]
ToxinsAbrin is a highly toxic plant protein encompassing four isoforms, abrin-a, -b, -c and -d. An abrin reference material was isolated from Abrus precatorius and certified (EURM-113) by the EuroBioTox consortium.
Roland Josuran +6 more
doaj +4 more sources
A Self-Driven Microfluidic Chip for Ricin and Abrin Detection [PDF]
Sensors, 2022 Ricin and abrin are phytotoxins that can be easily used as biowarfare and bioterrorism agents. Therefore, developing a rapid detection method for both toxins is of great significance in the field of biosecurity.
Xuexin Bai +13 more
doaj +4 more sources
Characterization of Lung Injury following Abrin Pulmonary Intoxication in Mice: Comparison to Ricin Poisoning [PDF]
Toxins, 2022 Abrin is a highly toxic protein obtained from the seeds of the rosary pea plant Abrus precatorius, and it is closely related to ricin in terms of its structure and chemical properties.
Anita Sapoznikov +6 more
doaj +2 more sources
Rapid Differential Detection of Abrin Isoforms by an Acetonitrile- and Ultrasound-Assisted On-Bead Trypsin Digestion Coupled with LC-MS/MS Analysis [PDF]
Toxins, 2021 The high toxic abrin from the plant Abrus precatorius is a type II ribosome-inactivating protein toxin with a human lethal dose of 0.1–1.0 µg/kg body weight.
Long-Hui Liang +6 more
doaj +2 more sources
Development and Evaluation of an Immuno-MALDI-TOF Mass Spectrometry Approach for Quantification of the Abrin Toxin in Complex Food Matrices [PDF]
Toxins, 2021 The toxin abrin found in the seeds of Abrus precatorius has attracted much attention regarding criminal and terroristic misuse over the past decade. Progress in analytical methods for a rapid and unambiguous identification of low abrin concentrations in ...
Sandrine Livet +7 more
doaj +2 more sources