Mapping Immunodominant Antibody Epitopes of Abrin [PDF]
Antibodies, 2020 Abrin, a toxin isolated from the seeds of Abrus precatorius (jequirity pea) is considered a biological threat agent by the Center for Disease Control and Prevention.
Ron Alcalay +6 more
doaj +5 more sources
Novel Phage Display-Derived Anti-Abrin Antibodies Confer Post-Exposure Protection against Abrin Intoxication [PDF]
Toxins, 2018 Abrin toxin is a type 2 ribosome inactivating glycoprotein isolated from the seeds of Abrus precatorius (jequirity pea). Owing to its high toxicity, relative ease of purification and accessibility, it is considered a biological threat agent.
Adva Mechaly +5 more
doaj +3 more sources
Establishment and Comparison of Detection Methods for Ricin and Abrin Based on Their Depurination Activities [PDF]
ToxinsRicin (RT) and abrin (AT) are plant toxins extracted from Ricinus communis and Abrus precatorius, respectively, and both have N-glycosidase activity. The detection of these toxins is vital because of their accessibility and bioterrorism potential.
Lina Dong +9 more
doaj +2 more sources
A Glycoprotein-Based Surface-Enhanced Raman Spectroscopy–Lateral Flow Assay Method for Abrin and Ricin Detection [PDF]
ToxinsAbrin and ricin, both type II ribosome-inactivating proteins, are toxins of significant concern and are under international restriction by the Chemical Weapons Convention and the Biological and Toxin Weapons Convention.
Lan Xiao +8 more
doaj +2 more sources
Ricin and Abrin in Biosecurity: Detection Technologies and Strategic Responses [PDF]
ToxinsPlant-derived toxins such as ricin and abrin represent some of the most potent biological agents known, posing significant threats to public health and security due to their high toxicity, relative ease of extraction, and widespread availability.
Wojciech Zajaczkowski +8 more
doaj +2 more sources
A Self-Driven Microfluidic Chip for Ricin and Abrin Detection [PDF]
Sensors, 2022 Ricin and abrin are phytotoxins that can be easily used as biowarfare and bioterrorism agents. Therefore, developing a rapid detection method for both toxins is of great significance in the field of biosecurity.
Xuexin Bai +13 more
doaj +2 more sources
Modulation of Ricin Intoxication by the Autophagy Inhibitor EACC [PDF]
Toxins, 2022 The compound EACC (ethyl (2-(5-nitrothiophene-2-carboxamido) thiophene-3-carbonyl) carbamate) was recently reported to inhibit fusion of autophagosomes with lysosomes in a reversible manner by inhibiting recruitment of syntaxin 17 to autophagosomes.
Kirsten Sandvig +4 more
doaj +2 more sources
Abrin immunotoxin: targeted cytotoxicity and intracellular trafficking pathway.
PLoS ONE, 2013 BackgroundImmunotherapy is fast emerging as one of the leading modes of treatment of cancer, in combination with chemotherapy and radiation. Use of immunotoxins, proteins bearing a cell-surface receptor-specific antibody conjugated to a toxin, enhances ...
Sudarshan Gadadhar, Anjali A Karande
doaj +5 more sources
Chimerolectins: Classification, structural architecture, and functional perspectives. [PDF]
Protein SciAbstract Lectins are proteins or glycoproteins capable of binding specifically and reversibly to carbohydrates, a property that, in itself, gives them great functional versatility in organisms from all kingdoms of nature. A subclass of these proteins, called chimerolectins, is composed of proteins that have at least one lectin domain associated with ...
Pinto-Junior VR +2 more
europepmc +2 more sources
Defense and Security Studies, 2022 Because of their high lethality and easy way to produce, abrin and ricin are often used as bioweapons. Sources of raw materials for the abrin and ricin manufacture can be found in various regions, especially in tropical countries.
Leni Tria Melati +2 more
doaj +1 more source