A Case of Poisoning with Abrus precatarius Complicated with Bilateral Basal Ganglia Haemorrhage [PDF]
Case Reports in Neurological Medicine, 2022 Abrus precatarius is a tropical climber, whose seeds contain abrin, which is known to cause toxicity in humans. We report a case of a young girl, who presented with haemorrhagic enterocolitis, bilateral septal vein thrombosis, and basal ganglia ...
Arun Rajaratnam +3 more
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Abrin immunotoxin: targeted cytotoxicity and intracellular trafficking pathway.
PLoS ONE, 2013 BackgroundImmunotherapy is fast emerging as one of the leading modes of treatment of cancer, in combination with chemotherapy and radiation. Use of immunotoxins, proteins bearing a cell-surface receptor-specific antibody conjugated to a toxin, enhances ...
Sudarshan Gadadhar, Anjali A Karande
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Regulation of Caspase-3 and Bcl-2 Expression in Dalton's Lymphoma Ascites Cells by Abrin [PDF]
, 2009 The role of abrin, a toxic lectin isolated from seeds of Abrus precatorius Linn in inducing apoptosis in murine Dalton's Lymphoma Ascites (DLA) cells was evaluated.
Bennett +25 more
core +5 more sources
Abrin Toxin Paradoxically Increases Protein Synthesis in Stimulated CD4+ T-Cells While Decreasing Protein Synthesis in Kidney Cells [PDF]
Current Issues in Molecular BiologyAbrin, a toxin of the rosary pea plant (Abras precatorius), has been implicated as causing an autoimmune demyelinating disease in humans, but the exact mechanisms responsible for the induction of these demyelinating conditions are still unknown.
Bradley Hernlem, Reuven Rasooly
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Llama-Derived Single Domain Antibodies Specific for Abrus Agglutinin [PDF]
Toxins, 2011 Llama derived single domain antibodies (sdAb), the recombinantly expressed variable heavy domains from the unique heavy-chain only antibodies of camelids, were isolated from a library derived from llamas immunized with a commercial abrin toxoid ...
James P. Carney +10 more
doaj +5 more sources
Sensitive Detection and Differentiation of Biologically Active Ricin and Abrin in Complex Matrices via Specific Neutralizing Antibody-Based Cytotoxicity Assay [PDF]
ToxinsRicin and abrin are highly potent plant-derived toxins, categorized as type II ribosome-inactivating proteins. High toxicity, accessibility, and the lack of effective countermeasures make them potential agents in bioterrorism and biowarfare, posing ...
Zhi Li +6 more
doaj +2 more sources
Novel Phage Display-Derived Anti-Abrin Antibodies Confer Post-Exposure Protection against Abrin Intoxication [PDF]
Toxins, 2018 Abrin toxin is a type 2 ribosome inactivating glycoprotein isolated from the seeds of Abrus precatorius (jequirity pea). Owing to its high toxicity, relative ease of purification and accessibility, it is considered a biological threat agent.
Adva Mechaly +5 more
doaj +3 more sources
Establishment and Comparison of Detection Methods for Ricin and Abrin Based on Their Depurination Activities [PDF]
ToxinsRicin (RT) and abrin (AT) are plant toxins extracted from Ricinus communis and Abrus precatorius, respectively, and both have N-glycosidase activity. The detection of these toxins is vital because of their accessibility and bioterrorism potential.
Lina Dong +9 more
doaj +2 more sources
Equal Neutralization Potency of Antibodies Raised against Abrin Subunits [PDF]
Antibodies, 2020 Abrin and ricin are potent AB toxins, which are considered biological threats. To date, there are no approved treatments against abrin or ricin intoxications.
Yoav Gal +9 more
doaj +2 more sources
Ricin and Abrin in Biosecurity: Detection Technologies and Strategic Responses [PDF]
ToxinsPlant-derived toxins such as ricin and abrin represent some of the most potent biological agents known, posing significant threats to public health and security due to their high toxicity, relative ease of extraction, and widespread availability.
Wojciech Zajaczkowski +8 more
doaj +2 more sources