Whole-Cell Multiparameter Assay for Ricin and Abrin Activity-Based Digital Holographic Microscopy [PDF]
Toxins, 2019 Ricin and abrin are ribosome-inactivating proteins leading to inhibition of protein synthesis and cell death. These toxins are considered some of the most potent and lethal toxins against which there is no available antidote.
Efi Makdasi +5 more
doaj +2 more sources
Endoplasmic reticulum stress-mediated activation of p38 MAPK, Caspase-2 and Caspase-8 leads to abrin-induced apoptosis. [PDF]
PLoS ONE, 2014 Abrin from Abrus precatorius plant is a potent protein synthesis inhibitor and induces apoptosis in cells. However, the relationship between inhibition of protein synthesis and apoptosis is not well understood.
Ritu Mishra, Anjali A Karande
doaj +3 more sources
Modulation of Ricin Intoxication by the Autophagy Inhibitor EACC [PDF]
Toxins, 2022 The compound EACC (ethyl (2-(5-nitrothiophene-2-carboxamido) thiophene-3-carbonyl) carbamate) was recently reported to inhibit fusion of autophagosomes with lysosomes in a reversible manner by inhibiting recruitment of syntaxin 17 to autophagosomes.
Kirsten Sandvig +4 more
doaj +2 more sources
Biomedical Research Journal, 2017 Abrin is a highly lethal ribosome-inactivating protein of high relevance in bio-warfare. Neutralizing antibodies to abrin reported so far afford protection in a very small window with no rescue observed post-abrin exposure.
Meenakshi Sundaram Kumar +3 more
doaj +2 more sources
Detection of Abrin by Electrochemiluminescence Biosensor Based on Screen Printed Electrode [PDF]
Sensors, 2018 For the convenience of fast measurement in the outdoor environment, a portable electrochemiluminescence biosensor with the screen-printed electrode as the reaction center was developed, which possesses the characteristics of high sensitivity, small scale,
Shuai Liu +6 more
doaj +2 more sources
A New Method for Abrin Detection Based on the Interaction between Target Molecules and Fluorescently Labeled Aptamers on Magnetic Microspheres. [PDF]
Materials (Basel), 2022 Liu Z +9 more
europepmc +3 more sources
A monoclonal antibody to an abrin chimera recognizing a unique epitope on abrin A chain confers protection from abrin-induced lethality [PDF]
Human Vaccines & Immunotherapeutics, 2015 Abrin, obtained from the seeds of Abrus precatorius plant, is a potent toxin belonging to the family of type II ribosome-inactivating proteins. Recently, a recombinant vaccine consisting of the A subunits of abrin and its homolog Abrus precatorius agglutinin (APA) was demonstrated to protect mice from abrin lethality.
Meenakshi Sundaram Kumar +1 more
openalex +4 more sources
Quantification of L-Abrine in Human and Rat Urine: A Biomarker for the Toxin Abrin [PDF]
Journal of Analytical Toxicology, 2009 Abrin is a toxic protein found in the jequirity seed. L-Abrine (N-methyl-tryptophan) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. Analysis of L-abrine was added to an existing method for quantifying ricinine as a marker for ricin exposure in human urine and analytically validated.
Rudolph C. Johnson +6 more
openalex +3 more sources
A Case of Abrin Toxin Poisoning, Confirmed via Quantitation of l-Abrine (N-Methyl-l-Tryptophan) Biomarker [PDF]
Journal of Medical Toxicology, 2014 The seeds of Abrus precatorius contain the highly toxic plant protein abrin. There is no antidote for abrin poisoning. Management, largely supportive, may consist of administering intravenous fluids, anti-emetics, and activated charcoal depending on the time of exposure.
Joe V. Wooten +6 more
openalex +4 more sources
Defense and Security Studies, 2022 Because of their high lethality and easy way to produce, abrin and ricin are often used as bioweapons. Sources of raw materials for the abrin and ricin manufacture can be found in various regions, especially in tropical countries.
Leni Tria Melati +2 more
doaj +1 more source