Results 31 to 40 of about 1,975 (144)
Nano‐Oncologicals: A Tortoise Trail Reaching New Avenues
Advanced Functional Materials, Volume 31, Issue 44, October 26, 2021., 2021 This is a critical review of the applications of nanotechnology for the improvement of oncological treatments based both on synthetic and biological molecules to target either tumor or immune cells. An overview of the early beginnings of the field, together with the most relevant formulations in clinical and preclinical evaluation, is also provided ...
Tamara G. Dacoba +8 more
wiley +1 more source
New Immunotherapeutic Approaches for Glioblastoma
Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021 Glioblastoma (GBM) is the most common primary malignant brain tumor with a high mortality rate. The current treatment consists of surgical resection, radiation, and chemotherapy; however, the median survival rate is only 12–18 months despite these alternatives, highlighting the urgent need to find new strategies.
Gustavo Ignacio Vázquez Cervantes +5 more
wiley +1 more source
Detection of Abrin Holotoxin Using Novel Monoclonal Antibodies
Toxins, 2017 Abrin, a member of the ribosome-inactivating protein family, is produced by the Abrus precatorius plant. Having the potential to pose a severe threat to both human and animal health, abrin is classified as a Select Agent by the U.S.
Xiaohua He +7 more
doaj +1 more source
Llama-Derived Single Domain Antibodies Specific for Abrus Agglutinin
Toxins, 2011 Llama derived single domain antibodies (sdAb), the recombinantly expressed variable heavy domains from the unique heavy-chain only antibodies of camelids, were isolated from a library derived from llamas immunized with a commercial abrin toxoid ...
James P. Carney +10 more
doaj +1 more source
A monoclonal antibody to an abrin chimera recognizing a unique epitope on abrin A chain confers protection from abrin-induced lethality [PDF]
Human Vaccines & Immunotherapeutics, 2015 Abrin, obtained from the seeds of Abrus precatorius plant, is a potent toxin belonging to the family of type II ribosome-inactivating proteins. Recently, a recombinant vaccine consisting of the A subunits of abrin and its homolog Abrus precatorius agglutinin (APA) was demonstrated to protect mice from abrin lethality.
Kumar, Meenakshi Sundaram +1 more
openaire +3 more sources
Quantification of L-Abrine in Human and Rat Urine: A Biomarker for the Toxin Abrin [PDF]
Journal of Analytical Toxicology, 2009 Abrin is a toxic protein found in the jequirity seed. L-Abrine (N-methyl-tryptophan) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. Analysis of L-abrine was added to an existing method for quantifying ricinine as a marker for ricin exposure in human urine and analytically validated.
Rudolph C, Johnson +6 more
openaire +5 more sources
Ricin and Abrin as Possible Agents of Bioterror
Вестник войск РХБ защиты, 2022 Plant toxins – ricin and abrin, obtained in a purified form from the beans of the castor bean and Abrus precatorius respectively, are considered by Western experts as potential damaging agents of a biological nature.
D. V. Pechenkin +5 more
doaj +1 more source
선진국방연구, 2023 Increasing non-traditional threats from biological or chemical weapons, the Organisation for the Prohibition of Chemical Weapons (OPCW) have tried to perform the preliminary analysis of biotoxin sample to standardize analysis methods and strengthen ...
Seungmin Kang +4 more
doaj +3 more sources
Biomedical Research Journal, 2017 Abrin is a highly lethal ribosome-inactivating protein of high relevance in bio-warfare. Neutralizing antibodies to abrin reported so far afford protection in a very small window with no rescue observed post-abrin exposure.
Meenakshi Sundaram Kumar +3 more
doaj +1 more source
Engineering in Life Sciences, Volume 20, Issue 11, Page 494-503, November 2020., 2020 Abstract Shiga toxin‐producing Escherichia coli (STEC) infection causes a series of diseases that are highly pathogenic and deadly in humans and animals, seriously endangering public health. Of the pathogenic factors within STEC, the two groups of Shiga toxin (Stx) consisting Stx1 and Stx2 plays a prominent role in the pathogenesis of STEC infection ...
Qiaozhen Wei +10 more
wiley +1 more source