Results 41 to 50 of about 5,034 (216)
New Immunotherapeutic Approaches for Glioblastoma
Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021 Glioblastoma (GBM) is the most common primary malignant brain tumor with a high mortality rate. The current treatment consists of surgical resection, radiation, and chemotherapy; however, the median survival rate is only 12–18 months despite these alternatives, highlighting the urgent need to find new strategies.
Gustavo Ignacio Vázquez Cervantes +5 more
wiley +1 more source
Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]
, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
core +2 more sources
Detection of Abrin Holotoxin Using Novel Monoclonal Antibodies
Toxins, 2017 Abrin, a member of the ribosome-inactivating protein family, is produced by the Abrus precatorius plant. Having the potential to pose a severe threat to both human and animal health, abrin is classified as a Select Agent by the U.S.
Xiaohua He +7 more
doaj +1 more source
Glycotope structures and intramolecular affinity factors of plant lectins for Tn/T antigens [PDF]
, 2011 B
A Babino +42 more
core +3 more sources
Chimerolectins: Classification, structural architecture, and functional perspectives [PDF]
Protein SciAbstract Lectins are proteins or glycoproteins capable of binding specifically and reversibly to carbohydrates, a property that, in itself, gives them great functional versatility in organisms from all kingdoms of nature. A subclass of these proteins, called chimerolectins, is composed of proteins that have at least one lectin domain associated with ...
Pinto‐Junior V +2 more
europepmc +2 more sources
Special issue: Ribosome-inactivating proteins : commemorative issue in honor of Professor Fiorenzo Stirpe [PDF]
, 2017 The family of ribosome-inactivating proteins (RIPs) groups all enzymes (EC.3.2.2.22) with a so-called RIP domain which comprises N-glycosidase activity and enables these proteins to catalytically inactivate ribosomes.[...
Van Damme, Els
core +3 more sources
Ricin and Abrin as Possible Agents of Bioterror
Вестник войск РХБ защиты, 2022 Plant toxins – ricin and abrin, obtained in a purified form from the beans of the castor bean and Abrus precatorius respectively, are considered by Western experts as potential damaging agents of a biological nature.
D. V. Pechenkin +5 more
doaj +1 more source
선진국방연구, 2023 Increasing non-traditional threats from biological or chemical weapons, the Organisation for the Prohibition of Chemical Weapons (OPCW) have tried to perform the preliminary analysis of biotoxin sample to standardize analysis methods and strengthen ...
Seungmin Kang +4 more
doaj +3 more sources
Engineering in Life Sciences, Volume 20, Issue 11, Page 494-503, November 2020., 2020 Abstract Shiga toxin‐producing Escherichia coli (STEC) infection causes a series of diseases that are highly pathogenic and deadly in humans and animals, seriously endangering public health. Of the pathogenic factors within STEC, the two groups of Shiga toxin (Stx) consisting Stx1 and Stx2 plays a prominent role in the pathogenesis of STEC infection ...
Qiaozhen Wei +10 more
wiley +1 more source
Scallop mantle toxin induces apoptosis in liver tissues of mice
Food Science &Nutrition, Volume 8, Issue 7, Page 3308-3316, July 2020., 2020 We had previously shown that the intake of scallop mantle tissue resulted in the death of mice and rats. In this study, we have investigated how liver tissue injuries are caused by the mantle toxin. Our results showed that the mantle toxin caused liver tissue apoptosis through the induction of oxidative stress, ER stress, and inflammation in the organ.
Takahide Kariya, Yasushi Hasegawa
wiley +1 more source