Acenocoumarol, an Anticoagulant Drug, Prevents Melanogenesis in B16F10 Melanoma Cells
Pharmaceuticals, 2023 Hyperpigmentation can occur in abnormal skin conditions such as melanomas, as well as in conditions including melasma, freckles, age spots, seborrheic keratosis, and café-au-lait spots (flat brown spots).
Chang-Gu Hyun
exaly +3 more sources
Molecules, 2023 The repurposing of already-approved drugs has emerged as an alternative strategy to rapidly identify effective, safe, and conveniently available new therapeutic indications against human diseases.
Chang-Gu Hyun, Hyun Chang-Gu
exaly +3 more sources
Comparative clinical outcomes of acenocoumarol versus direct oral anticoagulants (DOACs) and warfarin in patients with atrial fibrillation: real-world-evidence (SIESTA-A study) [PDF]
Frontiers in PharmacologyObjectiveThe aim of this study was to evaluate the effectiveness and safety of direct oral anticoagulants (DOACs: dabigatran, rivaroxaban, apixaban and edoxaban) and warfarin versus acenocoumarol in patients with atrial fibrillation under real-world ...
Ma Carmen Montero-Balosa +8 more
doaj +2 more sources
Obstructive Pharyngo-Laryngeal Hematoma Complicating Oral Anticoagulation: Case Report [PDF]
Iranian Journal of OtorhinolaryngologyIntroduction: Spontaneous pharyngo-laryngeal hematoma in patients receiving oral anticoagulants is rare and potentially fatal because of upper airway obstruction.
Maissa Lajhouri +5 more
doaj +2 more sources
The VKORC1 and CYP2C9 gene variants as pharmacogenetic factors in acenocoumarol therapy in Serbian patients - consideration of hypersensitivity and resistance [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2022 Introduction/Objective. Coumarin therapy represents one of the best models for applying pharmacogenetics. The contribution of factors influencing coumarin therapy can vary significantly between ethnic groups, which justifies conducting population ...
Rakićević Ljiljana +3 more
doaj +1 more source
Molecules, 2021 Vitamin K antagonists are indicated for the thromboprophylaxis in patients with mechanical prosthetic heart valves (MPHV). However, it is unclear whether some differences between acenocoumarol and warfarin in terms of anticoagulation quality do exist. We
Danilo Menichelli +8 more
doaj +1 more source
Corrigendum: A pharmacogenetically-guided acenocoumarol dosing algorithm for Chilean patients: a discovery cohort study [PDF]
Frontiers in PharmacologyAngela Roco +19 more
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Comparative Study on Estimation of Acenocoumarol Levels in Blood in Patients with Extremes and Normal INR Values after Valve Replacement Surgery [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: Acenocoumarol is an oral-anticoagulant which is commonly used but with narrow therapeutic index and there is no relation between dose and adverse effects. The response of acenocoumarol varies according to individual.
D. Jeyalakshmi +3 more
doaj +1 more source
Hellenic Journal of Cardiology, 2021 Background: To estimate the incidence of hemorrhagic events in patients with atrial fibrillation (AF) treated with acenocoumarol, and the management cost of those requiring hospitalization in Greece.
Georgia Kourlaba +7 more
doaj +1 more source
A novel, single algorithm approach to predict acenocoumarol dose based on CYP2C9 and VKORC1 allele variants. [PDF]
PLoS ONE, 2010 The identification of CYP2C9 and VKORC1 genes has strongly stimulated the research on pharmacogenetics of coumarins in the last decade. We assessed the combined influence of CYP2C9 *2 and *3, and VKORC1 c.-1639G>A, 497C>G, and 1173C>T variants, on ...
Zoraida Verde +7 more
doaj +1 more source