Results 31 to 40 of about 3,425 (149)

A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population.

PLoS ONE, 2016
There is a strong association between genetic polymorphisms and the acenocoumarol dosage requirements. Genotyping the polymorphisms involved in the pharmacokinetics and pharmacodynamics of acenocoumarol before starting anticoagulant therapy would result ...
Hoi Y Tong, Cristina Lucía Dávila-Fajardo, Alberto M Borobia, Luis Javier Martínez-González, Rubin Lubomirov, Laura María Perea León, María J Blanco Bañares, Xando Díaz-Villamarín, Carmen Fernández-Capitán, José Cabeza Barrera, Antonio J Carcas, PGX-ACE Investigators Group   +11 more
doaj   +1 more source

Therapeutic dosing of acenocoumarol: proposal of a population specific pharmacogenetic dosing algorithm and its validation in north Indians. [PDF]

PLoS ONE, 2012
OBJECTIVES: To develop a population specific pharmacogenetic acenocoumarol dosing algorithm for north Indian patients and show its efficiency in dosage prediction.
Saurabh Singh Rathore, Surendra Kumar Agarwal, Shantanu Pande, Sushil Kumar Singh, Tulika Mittal, Balraj Mittal   +5 more
doaj   +1 more source

Efficiency and effectiveness of the use of an acenocoumarol pharmacogenetic dosing algorithm versus usual care in patients with venous thromboembolic disease initiating oral anticoagulation: study protocol for a randomized controlled trial

Trials, 2012
Background Hemorrhagic events are frequent in patients on treatment with antivitamin-K oral anticoagulants due to their narrow therapeutic margin.
Carcas Antonio J, Borobia Alberto M, Velasco Marta, Abad-Santos Francisco, Díaz Manuel Quintana, Fernández-Capitán Carmen, Ruiz-Giménez Nuria, Madridano Olga, Sillero Pilar Llamas   +8 more
doaj   +1 more source

Coumarins Disrupt Cell–Cell Communication and Virulence in Priority Pathogens: Targeting the PQS Signalling System in Pseudomonas aeruginosa

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
The selective nature through which coumarin compounds produced by different species of plants target PQS signalling in Pseudomonas aeruginosa and select for distinct phenotypic responses in key pathogenic organisms adds to the growing evidence of their utility as natural virulence suppressors. ABSTRACT Cell‐to‐cell communication in microbial systems is
Dylan Boon, Benjamin O'Rourke, Muireann Carmody, David F. Woods, Antje Gloe, Daniel Platero‐Rochart, Pedro A. Sánchez‐Murcia, Gerard P. McGlacken, F. Jerry Reen   +8 more
wiley   +1 more source

Exploring acenocoumarol and silodosin in non-small cell lung cancer: Insights into EGFR-linked signaling mechanisms [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]

F1000Research
Background Non-small-cell lung cancer (NSCLC) is a highly morbid disease. Chemotherapy for NSCLC lacks specificity and efficacy mainly because of drug resistance.
Bharath Harohalli Byregowda, K Sreedhara Ranganath Pai, Megh Pravin Vithalkar, Krishnaprasad Baby, Usha Y Nayak, Yogendra Nayak, Swastika Maity   +6 more
doaj   +1 more source

Design, Synthesis, and Evaluation of Coumarin‐Rasagiline Hybrids as Multifunctional Neuroprotective Agents

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Novel coumarin‐rasagiline hybrid molecules were designed and synthesized as multifunctional agents targeting key pathological mechanisms of neurodegenerative diseases. These compounds exhibited hMAO‐B inhibitory activity, antioxidant and neuroprotective effects, supported by ADMET profiling and molecular modeling studies. The design of hybrid molecules
Aitor Carneiro, Sandra Barreiro, Claudia Sofia Machado, Miguel Pinto, Daniel Chavarria, Manuel Novás, Davide Crucitti, Carlos Fernandes, Maria João Matos   +8 more
wiley   +1 more source

Is the time in therapeutic range on coumarins predicted by previous time in therapeutic range?

Research and Practice in Thrombosis and Haemostasis, 2020
Background The benefit of vitamin K antagonists depends on the time within the therapeutic range (TTR). A patient’s previous TTR could be a factor in the decision to change the anticoagulation regimen.
Jasper H. A. vanMiert, Nic J. G. M. Veeger, Karina Meijer   +2 more
doaj   +1 more source

Effect of switching from acenocoumarol to phenprocoumon on time in therapeutic range and INR variability: A cohort study.

PLoS ONE, 2020
BackgroundTreatment with vitamin K antagonists (VKA) requires a high proportion of time in the therapeutic range (TTR) and a low international normalised ratio (INR) variability to be maximally safe and effective.
Jasper H A van Miert, Nic J G M Veeger, Arina J Ten Cate-Hoek, Margriet Piersma-Wichers, Karina Meijer   +4 more
doaj   +1 more source

Actionable Pharmacogenomics and Essential Medicines: An Analysis of WHO and African Lists for Safer and Efficacious Drug Use

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1371-1381, May 2026.
The World Health Organization Model Essential Medicines List and African national essential medicines lists (EMLs) detail drugs intended to be consistently available within national health systems, thereby supporting clinicians and pharmacists in making evidence‐based treatment decisions.
Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Janine Scholefield, Collen Masimirembwa   +5 more
wiley   +1 more source

Synthesis and structure of (R,S)-2-methyl-4-(4-nitrophenyl)-pyrano[3,2-c]chromen-5(4H)-one

Macedonian Journal of Chemistry and Chemical Engineering, 2012
In this paper, the synthesis and structure of a novel pyrano[3,2-c]coumarin, which was obtained unexpectedly in a reaction of phosphoryl chloride and acenocoumarol, are presented.
Rosica P. Nikolova, Boris Shivachev, Bozhana Mikhova, Bistra Stamboliyska, Kristina Mladenovska, Ana P. Panovska, Emil Popovski   +6 more
doaj   +1 more source