Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection [PDF]
Molecules, 2017 Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) play essential roles in cell energy metabolism. Dysregulation of the biosynthesis and functioning of both compounds may contribute to various pathological conditions.
Yevgeniya I. Shurubor +7 more
doaj +3 more sources
Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design [PDF]
Nature Communications, 2019 Acetyl-CoA is a fundamental metabolite for all life on Earth, and is also a key starting point for the biosynthesis of a variety of industrial chemicals and natural products.
Yuwan Liu, Xiya Wang, Cui Liu
exaly +3 more sources
Synthetic Biology for Engineering Acetyl Coenzyme A Metabolism in Yeast [PDF]
mBio, 2014 The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels, chemicals, and pharmaceuticals. The use of this cell factory for cost-efficient production of novel fuels and chemicals requires high yields and low by-product ...
Jens Nielsen
doaj +3 more sources
Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress. [PDF]
Sci Adv, 2023 Proliferating cells rely on acetyl-CoA to support membrane biogenesis and acetylation. Several organelle-specific pathways are available for provision of acetyl-CoA as nutrient availability fluctuates, so understanding how cells maintain acetyl-CoA flux ...
Kuna RS +9 more
europepmc +2 more sources
Protein acetylation and acetyl coenzyme a metabolism in budding yeast. [PDF]
Eukaryot Cell, 2014 Cells sense and appropriately respond to the physical conditions and availability of nutrients in their environment. This sensing of the environment and consequent cellular responses are orchestrated by a multitude of signaling pathways and typically ...
Galdieri L +4 more
europepmc +5 more sources
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. [PDF]
Cell Chem Biol, 2022 Summary We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a druggable target, using genetic and chemical validation. In vitro evolution of resistance with two antiplasmodial drug-like compounds (MMV019721 and MMV084978 ...
Summers RL +33 more
europepmc +2 more sources
Acetyl Coenzyme A Synthase 2 Acts as a Prognostic Biomarker Associated with Immune Infiltration in Cervical Squamous Cell Carcinoma. [PDF]
Cancers (Basel), 2021 Simple Summary Cellular metabolism has become a key determinant of cancer cell and immune cell viability and function. To sustain the enormous anabolic demands, tumors adopt a specialized metabolism different from that of normal cells.
Li CJ +5 more
europepmc +2 more sources
Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. [PDF]
Cell Metab, 2019 Summary The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a master regulator of cell growth and metabolism. Leucine (Leu) activates mTORC1 and many have tried to identify the mechanisms whereby cells sense Leu in this context.
Son SM +6 more
europepmc +2 more sources
Extending the Scope of 1H NMR Spectroscopy for the Analysis of Cellular Coenzyme A and Acetyl Coenzyme A. [PDF]
Anal Chem, 2019 Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) are ubiquitous cellular molecules, which mediate hundreds of anabolic and catabolic reactions including energy metabolism.
Nagana Gowda GA, Abell L, Tian R.
europepmc +2 more sources
Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models. [PDF]
Emerg Microbes Infect, 2019 Flaviviruses are (re)-emerging RNA viruses strictly dependent on lipid metabolism for infection. In the search for host targeting antivirals, we explored the effect of pharmacological modulation of fatty acid metabolism during flavivirus infection ...
Jiménez de Oya N +15 more
europepmc +2 more sources