Synthetic Biology for Engineering Acetyl Coenzyme A Metabolism in Yeast [PDF]
mBio, 2014 The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels, chemicals, and pharmaceuticals. The use of this cell factory for cost-efficient production of novel fuels and chemicals requires high yields and low by-product ...
Jens Nielsen
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Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection [PDF]
Molecules, 2017 Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) play essential roles in cell energy metabolism. Dysregulation of the biosynthesis and functioning of both compounds may contribute to various pathological conditions.
Yevgeniya I. Shurubor +7 more
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An essential role of acetyl coenzyme A in the catalytic cycle of insect arylalkylamine N-acetyltransferase [PDF]
Communications Biology, 2020 Wu et al. provide insight to the role of acetyl coenzyme A in regulating N-acetylation in insect AANAT using ITC and NMR methods. These results provide useful data on the structural function of insect AANATs.
Chu-Ya Wu +8 more
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Regulation of
mSphere, 2018 To satisfy its fatty acid needs, the extracellular eukaryotic parasite Trypanosoma brucei relies on two mechanisms: uptake of fatty acids from the host and de novo synthesis. We hypothesized that T.
Sunayan S. Ray +2 more
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Regulation of Acetyl-Coenzyme A Carboxylase and Acetyl-Coenzyme A Synthetase in Spinach Chloroplasts [PDF]
Zeitschrift für Naturforschung C, 1984 In analogy to chloroplast fatty acid synthesis from acetate the key enzymes of acetate fixation, acetyl-CoA synthetase and acetyl-CoA carboxylase, in rapidly Triton X-100 lysed spinach chloroplasts show an activation by light and deactivation in the dark. The stim ulation of acetyl-CoA carboxylase by dithiothreitol in darkened chloroplasts points to an
Andreas Sauer, Klaus‐Peter Heise
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Dynamic Metabolic Rewiring Enables Efficient Acetyl Coenzyme A Assimilation in
mBio, 2019 During growth, microorganisms have to balance metabolic flux between energy and biosynthesis. One of the key intermediates in central carbon metabolism is acetyl coenzyme A (acetyl-CoA), which can be either oxidized in the citric acid cycle or ...
Katharina Kremer +8 more
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Human N-Acetyltransferase 1 and 2 Differ in Affinity Towards Acetyl-Coenzyme A Cofactor and N-Hydroxy-Arylamine Carcinogens. [PDF]
Front Pharmacol, 2022 Hein DW, Doll MA, Habil MR.
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Protein acetylation and acetyl coenzyme a metabolism in budding yeast. [PDF]
Eukaryot Cell, 2014 ABSTRACT Cells sense and appropriately respond to the physical conditions and availability of nutrients in their environment. This sensing of the environment and consequent cellular responses are orchestrated by a multitude of signaling pathways and typically involve changes in transcription and metabolism. Recent discoveries suggest that the
Galdieri L +4 more
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Acetyl-coenzyme A: a metabolic master regulator of autophagy and longevity. [PDF]
Autophagy, 2014 As the major lysosomal degradation pathway, autophagy represents the guardian of cellular homeostasis, removing damaged and potentially harmful material and replenishing energy reserves in conditions of starvation. Given its vast physiological importance, autophagy is crucially involved in the process of aging and associated pathologies.
Schroeder S +15 more
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Oxidized Low-Density Lipoprotein Accumulation in Macrophages Impairs Lipopolysaccharide-Induced Activation of AKT2, ATP Citrate Lyase, Acetyl-Coenzyme A Production, and Inflammatory Gene H3K27 Acetylation. [PDF]
ImmunohorizonsTing KKY +13 more
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