Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy
Cancer Science, EarlyView.This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang +6 more
wiley +1 more source
Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress. [PDF]
Sci Adv, 2023 Kuna RS +9 more
europepmc +1 more source
Mitochondrial respiration and characteristics of skeletal muscles in children with cerebral palsy
Developmental Medicine &Child Neurology, EarlyView.Skeletal muscles utilize numerous mitochondria for energy production needed during muscle contraction. Mitochondria produce this energy through the electron transport chain. After an injury such as ACL‐injury in typically developing children, there is a reduction in muscle mitochondrial respiration and content.
Sudarshan Dayanidhi +10 more
wiley +1 more source
Prebiotic aqueous reactions catalyzed by native nickel without hydrogen
The FEBS Journal, EarlyView.Serpentinizing (H2‐producing) hydrothermal vents are candidate environments for metabolic origin. They generate highly reducing conditions that convert CO2 to formate and methane in abiotic reactions resembling reactions of the acetyl‐CoA pathway of CO2 fixation. They also contain natural catalysts. Native nickel (Ni0), like Fe0, Co0, and their alloys,
Carolina Garcia Garcia +2 more
wiley +1 more source
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Correlation of acetyl-coenzyme A carboxylase 1 with Th17 and Th1 cells, serving as a potential prognostic biomarker for acute ischemic stroke patients. [PDF]
J Clin Lab Anal, 2022 Jiang J +5 more
europepmc +1 more source
Journal of Diabetes Investigation, EarlyView.ABSTRACT Aims To examine the association between branched‐chain α‐keto acids (BCKAs) and pancreatic steatosis in patients with type 2 diabetes (T2DM). Methods This cross‐sectional study was conducted from January 2023 to March 2025. Upper abdominal computerized tomography was performed, pancreatic volume (PV), PV index (PVI), CT attenuation of pancreas
Jie Gao +9 more
wiley +1 more source
Acetyl coenzyme A kinetic studies on N-acetylation of environmental carcinogens by human N-acetyltransferase 1 and its NAT1*14B variant. [PDF]
Front Pharmacol, 2022 Habil MR, Doll MA, Hein DW.
europepmc +1 more source
Journal of Integrative Plant Biology, EarlyView.Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang +7 more
wiley +1 more source
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. [PDF]
Cell Chem Biol, 2022 Summers RL +33 more
europepmc +1 more source