Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux
Metabolites, 2020 Acetyl-CoA is a key metabolite precursor for the biosynthesis of lipids, polyketides, isoprenoids, amino acids, and numerous other bioproducts which are used in various industries.
Jason T. Ku, Arvin Y. Chen, Ethan I. Lan
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Molecular mechanisms of the non-coenzyme action of thiamin in brain. Biochemical, structural and pathway analysis [PDF]
, 2015 Thiamin (vitamin B1) is a pharmacological agent boosting central metabolism through the action of the coenzyme thiamin diphosphate (ThDP). However, positive effects, including improved cognition, of high thiamin doses in neurodegeneration may be ...
Andrey, Vovk +9 more
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Geographic Distribution of Ryegrass Resistent to the Clethodim Herbicide in Rio Grande do Sul1 [PDF]
Planta Daninha, 2016 Ryegrass is a weed of annual cycle that is present in winter crops, in orchards and vineyards of the South region of Brazil. The species is normally controlled by the glyphosate herbicide, but the continuous use of this product caused the selection of ...
L. VARGAS +3 more
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Lipoic acid and diabetes-Part III: Metabolic role of acetyl dihydrolipoic acid [PDF]
, 1986 Rat liver lipoyl transacetylase catalyzes the formation of acetyl dihydrolipoic acid from acetyl coenzyme A and dihydrolipoic acid. In an earlier paper the formation of acetyl dihydrolipoic from pyruvate and dihydrolipoic acid catalyzed by pyruvate ...
Gandhi, V. M. +3 more
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Acetyl-coenzyme A Synthetase (Acs) Assay
Bio-Protocol, 2012 Acetyl-coenzyme A synthethase (Acs, E.C.6.2.1.1) is an acetate activating enzyme widely represented in nature from bacteria to human. Its function is important for cellular catabolism, especially in order to support microbial growth at low concentrations
Sara Castaño Cerezo +2 more
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Oncometabolites: tailoring our genes [PDF]
, 2015 Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis.
Avril N, Buck AC, Gimm O, Higashi K
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Pyrophosphate-Dependent ATP Formation from Acetyl Coenzyme A in Syntrophus aciditrophicus, a New Twist on ATP Formation. [PDF]
, 2016 UnlabelledSyntrophus aciditrophicus is a model syntrophic bacterium that degrades key intermediates in anaerobic decomposition, such as benzoate, cyclohexane-1-carboxylate, and certain fatty acids, to acetate when grown with hydrogen-/formate-consuming ...
Erde, Jonathan +17 more
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Minimizing acetate formation in E. coli fermentations [PDF]
, 2007 Escherichia coli remains the best established production organisms in industrial biotechnology. However, during aerobic fermentation runs at high growth rates, considerable amounts of acetate are accumulated as by-product.
De Maeseneire, Sofie +3 more
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Adenosine Triphosphate and Carbon Efficient Route to Second Generation Biofuel Isopentanol. [PDF]
, 2020 Climate change necessitates the development of CO2 neutral or negative routes to chemicals currently produced from fossil carbon. In this paper we demonstrate a pathway from the renewable resource glucose to next generation biofuel isopentanol by pairing
Chiniquy, Jennifer +9 more
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The Structural Basis of Coenzyme A Recycling in a Bacterial Organelle. [PDF]
, 2016 Bacterial Microcompartments (BMCs) are proteinaceous organelles that encapsulate critical segments of autotrophic and heterotrophic metabolic pathways; they are functionally diverse and are found across 23 different phyla. The majority of catabolic BMCs (
Erbilgin, Onur +2 more
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