Protein acetylation and acetyl coenzyme a metabolism in budding yeast. [PDF]
Eukaryot Cell, 2014 Cells sense and appropriately respond to the physical conditions and availability of nutrients in their environment. This sensing of the environment and consequent cellular responses are orchestrated by a multitude of signaling pathways and typically ...
Galdieri L +4 more
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Staphylococcus aureus modulates the activity of acetyl-Coenzyme A synthetase (Acs) by sirtuin-dependent reversible lysine acetylation. [PDF]
Mol Microbiol, 2019 Lysine acylation is a posttranslational modification used by cells of all domains of life to modulate cellular processes in response to metabolic stress. The paradigm for the role of lysine acylation in metabolism is the acetyl‐coenzyme A synthetase (Acs)
Burckhardt RM +2 more
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An essential role of acetyl coenzyme A in the catalytic cycle of insect arylalkylamine N-acetyltransferase [PDF]
Communications Biology, 2020 Wu et al. provide insight to the role of acetyl coenzyme A in regulating N-acetylation in insect AANAT using ITC and NMR methods. These results provide useful data on the structural function of insect AANATs.
Chu-Ya Wu +8 more
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Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. [PDF]
Cell Chem Biol, 2022 Summers RL +33 more
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Regulation of
mSphere, 2018 To satisfy its fatty acid needs, the extracellular eukaryotic parasite Trypanosoma brucei relies on two mechanisms: uptake of fatty acids from the host and de novo synthesis. We hypothesized that T.
Sunayan S. Ray +2 more
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Acetyl-coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double-blind, crossover study. [PDF]
Hepatology, 2017 NDI‐010976, an allosteric inhibitor of acetyl‐coenzyme A carboxylases (ACC) ACC1 and ACC2, reduces hepatic de novo lipogenesis (DNL) and favorably affects steatosis, inflammation, and fibrosis in animal models of fatty liver disease.
Stiede K +9 more
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Dynamic Metabolic Rewiring Enables Efficient Acetyl Coenzyme A Assimilation in
mBio, 2019 During growth, microorganisms have to balance metabolic flux between energy and biosynthesis. One of the key intermediates in central carbon metabolism is acetyl coenzyme A (acetyl-CoA), which can be either oxidized in the citric acid cycle or ...
Katharina Kremer +8 more
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Acetyl-coenzyme A Synthetase (Acs) Assay [PDF]
Bio-Protocol, 2012 Acetyl-coenzyme A synthethase (Acs, E.C.6.2.1.1) is an acetate activating enzyme widely represented in nature from bacteria to human. Its function is important for cellular catabolism, especially in order to support microbial growth at low concentrations
Sara Castaño Cerezo +2 more
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Acetyl-coenzyme A: a metabolic master regulator of autophagy and longevity. [PDF]
Autophagy, 2014 As the major lysosomal degradation pathway, autophagy represents the guardian of cellular homeostasis, removing damaged and potentially harmful material and replenishing energy reserves in conditions of starvation. Given its vast physiological importance,
Schroeder S +15 more
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Determination of acetyl coenzyme A. Interference by a contaminant in malate dehydrogenase
Journal of Lipid Research, 1972 Spectrophotometric determinations of acetyl CoA with malate dehydrogenase and citrate synthase are likely to overestimate the amount of acetyl CoA in solutions containing acetoacetyl CoA, since commercial preparations of malate dehydrogenase may contain ...
I. Mulder
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