Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. [PDF]
Cell Metab, 2019 Son SM +6 more
europepmc +2 more sources
PanM, an Acetyl-Coenzyme A Sensor Required for Maturation of
mBio, 2012 Coenzyme A (CoA) is essential for cellular chemistry in all forms of life. The pantothenate moiety of CoA is generated from the condensation of pantoate and β-alanine.
Tara N. Stuecker +2 more
doaj +2 more sources
mBio, 2014 The energetic (ATP) cost of biochemical pathways critically determines the maximum yield of metabolites of vital or commercial relevance. Cytosolic acetyl coenzyme A (acetyl-CoA) is a key precursor for biosynthesis in eukaryotes and for many industrially
Barbara U. Kozak +9 more
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Regulation of autophagy by cytosolic acetyl-coenzyme A. [PDF]
Molecular Cell, 2014 Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritional status at the crossroads of fat, sugar, and protein catabolism. Here we show that nutrient starvation causes rapid depletion of AcCoA. AcCoA depletion entailed the commensurate reduction in the overall acetylation of cytoplasmic proteins, as well as the induction of autophagy, a ...
Guillermo Mariño +31 more
semanticscholar +7 more sources
THE NET ENZYMATIC SYNTHESIS OF ACETYL COENZYME A
Journal of Biological Chemistry, 1952 Earl R. Stadtman
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Acetyl coenzyme A: a central metabolite and second messenger. [PDF]
Cell Metabolism, 2015 Acetyl-coenzyme A (acetyl-CoA) is a central metabolic intermediate. The abundance of acetyl-CoA in distinct subcellular compartments reflects the general energetic state of the cell. Moreover, acetyl-CoA concentrations influence the activity or specificity of multiple enzymes, either in an allosteric manner or by altering substrate availability ...
F. Pietrocola +4 more
semanticscholar +4 more sources
From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2. [PDF]
PLoS ONE, 2014 Acetyl Coenzyme A-dependent N-, O- and N,O-acetylation of aromatic amines and hydrazines by arylamine N-acetyltransferases is well characterised. Here, we describe experiments demonstrating that human arylamine N-acetyltransferase Type 1 and its murine ...
Nicola Laurieri +7 more
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The Roles of Coenzyme A Binding Pocket Residues in Short and Medium Chain Acyl-CoA Synthetases
Life, 2023 Short- and medium-chain acyl-CoA synthetases catalyze similar two-step reactions in which acyl substrate and ATP bind to form an enzyme-bound acyl-adenylate, then CoA binds for formation of the acyl-CoA product.
Yu Meng +3 more
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Regulation of Acetyl-Coenzyme A Carboxylase and Acetyl-Coenzyme A Synthetase in Spinach Chloroplasts [PDF]
Zeitschrift für Naturforschung C, 1984 In analogy to chloroplast fatty acid synthesis from acetate the key enzymes of acetate fixation, acetyl-CoA synthetase and acetyl-CoA carboxylase, in rapidly Triton X-100 lysed spinach chloroplasts show an activation by light and deactivation in the dark. The stim ulation of acetyl-CoA carboxylase by dithiothreitol in darkened chloroplasts points to an
Klaus-Peter Heise, Andreas Sauer
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Who Rules the Cell? An Epi-Tale of Histone, DNA, RNA, and the Metabolic Deep State
Frontiers in Plant Science, 2020 Epigenetics refers to the mode of inheritance independent of mutational changes in the DNA. Early evidence has revealed methylation, acetylation, and phosphorylation of histones, as well as methylation of DNA as part of the underlying mechanisms.
Jeffrey Leung, Valérie Gaudin
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