Results 1 to 10 of about 9,200 (244)

Skeletal muscle energetics during submaximal contractions are linked to metabolic performance during ambulatory exercise: A pilot study in male adults [PDF]

Physiological Reports
Skeletal muscle's capacity for oxidative energy production can be measured in vivo by phosphocreatine (PCr) recovery following maximal contractions inside a magnetic resonance scanner.
Christopher M. T. Hayden, Michael A. Busa, Zoe H. Smith, Rajakumar Nagarajan, Luke R. Arieta, Jane A. Kent   +5 more
doaj   +2 more sources

Elucidating the causal links between plasma and cerebrospinal fluid metabolites and pituitary tumors: a Mendelian randomization analysis [PDF]

Frontiers in Endocrinology
BackgroundPituitary tumors (PTs) are common benign intracranial tumors. Investigating the metabolites in serum and cerebrospinal fluid in PTs is essential to understanding the underlying biological mechanisms and identifying new biomarkers and ...
Wencai Wang, Menghao Liu, Zun Wang, Wei Ye, Xianfeng Li   +4 more
doaj   +2 more sources

Integrated metabolomics and lipidomics reveal fatty acid dysregulation in aortic dissection independent of hypertension [PDF]

Scientific Reports
Aortic dissection (AD), characterized by rupture of the aortic wall, presents significant diagnostic challenges due to its rapid onset and nonspecific clinical symptoms.
Xuanxuan Bai, Hongbin Lin, Weiliang Zheng, Lijun Sun, Shuangkun Chen, Lin Lu, Lulu Chen, Xijie Wu   +7 more
doaj   +2 more sources

Longitudinal Metabolomic Profiling of Amino Acids and Lipids across Healthy Pregnancy. [PDF]

PLoS ONE, 2015
Pregnancy is characterized by a complexity of metabolic processes that may impact fetal development and ultimately, infant health outcomes. However, our understanding of whole body maternal and fetal metabolism during this critical life stage remains ...
Karen L Lindsay, Christian Hellmuth, Olaf Uhl, Claudia Buss, Pathik D Wadhwa, Berthold Koletzko, Sonja Entringer   +6 more
doaj   +7 more sources

Discovery and validation of acetyl-L-carnitine in serum for diagnosis of major depressive disorder and remission status through metabolomic approach

Frontiers in Psychiatry, 2022
Major depressive disorder (MDD) is one of the most common psychiatric disorders that accompany psychophysiological and mood changes. However, the pathophysiology-based disease mechanism of MDD is not yet fully understood, and diagnosis is also conducted ...
Seungyeon Lee, Sora Mun, You-Rim Lee, Hyebin Choi, Eun-Jeong Joo, Eun-Jeong Joo, Hee-Gyoo Kang, Hee-Gyoo Kang, Jiyeong Lee   +8 more
doaj   +1 more source

Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites

Metabolites, 2023
Mitochondrial health declines with age, and older patients can demonstrate dysfunction in mitochondrial-rich tissues, such as cardiac and skeletal muscle. Aged mitochondria may make older adults more susceptible to adverse drug reactions (ADRs).
Jennifer Diaz-Espinosa, Kathleen A. Stringer, Gus R. Rosania   +2 more
doaj   +1 more source

Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. [PDF]

, 2013
Metabolomic profiling can be used to study disease-induced changes in inflammatory bowel diseases (IBD). The aim of this study was to investigate the difference in the metabolomic profile of males and females as they developed IBD.
Churchill, Thomas A, Doyle, Jason, Fedorak, Richard N, Foshaug, Rae R, Slupsky, Carolyn M, Sydora, Beate C, Tso, Victor K   +6 more
core   +9 more sources

The Role of Acetyl-Carnitine and Rehabilitation in the Management of Patients with Post-COVID Syndrome: Case-Control Study

Applied Sciences, 2022
Post-COVID syndrome is characterized by the persistence of nonspecific disabling symptoms, even several months after the resolution of the infection, with clinical characteristics similar to fibromyalgia (FM) and a prevalence of 31%.
Dalila Scaturro, Fabio Vitagliani, Vito Emanuele Di Bella, Vincenzo Falco, Sofia Tomasello, Lorenza Lauricella, Giulia Letizia Mauro   +6 more
doaj   +1 more source

Multidimensional predictors of antidepressant responses: Integrating mitochondrial, genetic, metabolic and environmental factors with clinical outcomes

Neurobiology of Stress, 2021
Major depressive disorder (MDD) is a primary psychiatric illness worldwide; there is a dearth of new mechanistic models for the development of better therapeutic strategies.
Carla Nasca, Olivia Barnhill, Paolo DeAngelis, Kathleen Watson, Jue Lin, James Beasley, Sarah P. Young, Alison Myoraku, Josh Dobbin, Benedetta Bigio, Bruce McEwen, Natalie Rasgon   +11 more
doaj   +1 more source

Metabolomic analysis of cricket paralysis virus infection in Drosophila S2 cells reveals divergent effects on central carbon metabolism as compared with silkworm Bm5 cells [PDF]

, 2020
High-throughput approaches have opened new opportunities for understanding biological processes such as persistent virus infections, which are widespread.
Meeus, Ivan, Smagghe, Guy, Swevers, Luc, Van Meulebroek, Lieven, Vanhaecke, Lynn, Wang, Luoluo   +5 more
core   +1 more source