Results 11 to 20 of about 9,200 (244)

Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis

Science Advances, 2023
The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate and acetate, which are processed to acetyl-CoA by ATP-citrate lyase (ACLY) and acyl-CoA synthetase short-chain 2 (ACSS2), respectively. It is
Luke T. Izzo, Sophie Trefely, Christina Demetriadou, Jack M. Drummond, Takuya Mizukami, Nina Kuprasertkul, Aimee T. Farria, Phuong T. T. Nguyen, Nivitha Murali, Lauren Reich, Daniel S. Kantner, Joshua Shaffer, Hayley Affronti, Alessandro Carrer, Andrew Andrews, Brian C. Capell, Nathaniel W. Snyder, Kathryn E. Wellen   +17 more
openaire   +4 more sources

l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility [PDF]

Reproduction and Fertility, 2020
Fifteen percent of couples are globally estimated to be infertile, with up to half of these cases attributed to male infertility. Reactive oxidative species (ROS) are known to damage sperm leading to impaired quantity and quality. Although not routinely assessed, oxidative stress is a common underlying pathology in infertile men. Antioxidants have been
Khaw, Shen Chuen, Wong, Zhen Zhe, Anderson, Richard A., Martins Da Silva, Sarah   +3 more
openaire   +5 more sources

Synergic action of L-acetylcarnitine and L-methylfolate in Mouse Models of Stress-Related Disorders and Human iPSC-Derived Dopaminergic Neurons

Frontiers in Pharmacology, 2022
The epigenetic agents, L-acetylcarnitine (LAC) and L-methylfolate (MF) are putative candidates as add-on drugs in depression. We evaluated the effect of a combined treatment with LAC and MF in two different paradigms of chronic stress in mice and in ...
Rosamaria Orlando, Rosamaria Orlando, Roxana Paula Ginerete, Laura Cavalleri, Vincenza Aliperti, Tiziana Imbriglio, Giuseppe Battaglia, Giuseppe Battaglia, Anna Rita Zuena, Ferdinando Nicoletti, Ferdinando Nicoletti, Emilio Merlo Pich, Ginetta Collo   +12 more
doaj   +2 more sources

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]

Molecular Pain, 2017
Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe, Bernabucci, Matteo, Bruno, Valeria Maria Gloria, Cannella, Milena, Gradini, Roberto, Imbriglio, Tiziana, Mascio, Giada, Nicoletti, Ferdinando, Notartomaso, Serena, Scarselli, Pamela, Zappulla, Cristina   +10 more
core   +2 more sources

Acetylcarnitine Is Associated With Cardiovascular Disease Risk in Type 2 Diabetes Mellitus

Frontiers in Endocrinology, 2021
ObjectiveThis study aimed to identify the association between specific short-chain acylcarnitines and cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM).MethodWe retrieved 1,032 consecutive patients with T2DM who meet the inclusion and ...
Shuo Zhao, Shuo Zhao, Ming-Li Liu, Bing Huang, Fu-Rong Zhao, Ying Li, Xue-Ting Cui, Rong Lin   +7 more
doaj   +2 more sources

Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial

EBioMedicine, 2019
Background: Type 2 diabetes patients and individuals at risk of developing diabetes are characterized by metabolic inflexibility and disturbed glucose homeostasis.
Yvonne MH Bruls, Marlies de Ligt, Lucas Lindeboom, Esther Phielix, Bas Havekes, Gert Schaart, Esther Kornips, Joachim E Wildberger, Matthijs KC Hesselink, Deborah Muoio, Patrick Schrauwen, Vera B Schrauwen-Hinderling   +11 more
doaj   +2 more sources

Correlation between skeletal muscle acetylcarnitine and phosphocreatine metabolism during submaximal exercise and recovery: interleaved 1H/31P MRS 7 T study

Scientific Reports
Acetylcarnitine is an essential metabolite for maintaining metabolic flexibility and glucose homeostasis. The in vivo behavior of muscle acetylcarnitine content during exercise has not been shown with magnetic resonance spectroscopy.
Radka Klepochová, Fabian Niess, Martin Meyerspeer, Dorota Slukova, Ivica Just, Siegfried Trattnig, Jozef Ukropec, Barbara Ukropcová, Alexandra Kautzky-Willer, Michael Leutner, Martin Krššák   +10 more
doaj   +2 more sources

L-acetylcarnitine for treating fragile X syndrome

Cochrane Database of Systematic Reviews, 2015
People with fragile X syndrome (FXS) have an intellectual dysfunction that can range from very mild to severe. Symptoms can include speech and language delays and behavioural difficulties such as aggression or self injurious behaviours, emotional lability, and anxiety-related problems (for example obsessive-compulsive symptoms and perseverative ...
José-Ramón, Rueda, Virginia, Guillén, Javier, Ballesteros, Maria-Isabel, Tejada, Ivan, Solà   +4 more
semanticscholar   +5 more sources

l-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug [PDF]

International Journal of Molecular Sciences, 2017
Current therapy of mood disorders has several limitations. Although a high number of drugs are clinically available, as of today, nearly two-thirds of individuals do not achieve full symptomatic remission after treatment with conventional antidepressants.
Santina Chiechio, Pier Canonico, Mariagrazia Grilli   +2 more
openaire   +3 more sources

N-acetyltaurine and Acetylcarnitine Production for the Mitochondrial Acetyl-CoA Regulation in Skeletal Muscles during Endurance Exercises

Metabolites, 2021
During endurance exercises, a large amount of mitochondrial acetyl-CoA is produced in skeletal muscles from lipids, and the excess acetyl-CoA suppresses the metabolic flux from glycolysis to the TCA cycle. This study evaluated the hypothesis that taurine
Teruo Miyazaki, Yuho Nakamura-Shinya, Kei Ebina, Shoichi Komine, Song-Gyu Ra, Keisuke Ishikura, Hajime Ohmori, Akira Honda   +7 more
doaj   +2 more sources