Results 21 to 30 of about 9,200 (244)

Long–echo time MR spectroscopy for skeletal muscle acetylcarnitine detection [PDF]

Journal of Clinical Investigation, 2014
Animal models suggest that acetylcarnitine production is essential for maintaining metabolic flexibility and insulin sensitivity. Because current methods to detect acetylcarnitine involve biopsy of the tissue of interest, noninvasive alternatives to measure acetylcarnitine concentrations could facilitate our understanding of its physiological relevance
Lindeboom, L., Nabuurs, C.I., Hoeks, J., Brouwers, B., Phielix, E., Kooi, M.E., Hesselink, M.K., Wildberger, J.E., Stevens, R.D., Koves, T., Muoio, D. M., Schrauwen, P., Schrauwen-Hinderling, V.B.   +12 more
openaire   +4 more sources

Carnitine supplementation improves insulin sensitivity and skeletal muscle acetylcarnitine formation in patients with type 2 diabetes. [PDF]

Diabetes Obes Metab
Recently, we reported that increasing free carnitine availability resulted in elevated skeletal muscle acetylcarnitine concentrations and restored metabolic flexibility in individuals who have impaired glucose tolerance.
Op den Kamp-Bruls YMH, Op den Kamp YJM, Veeraiah P, Zapata Perez R, Phielix E, Havekes B, Schaart G, Kornips E, Berendsen BRB, Virmani A, Wildberger JE, Houtkooper RH, Hesselink MKC, Schrauwen P, Schrauwen-Hinderling VB.   +14 more
europepmc   +2 more sources

L-Acetylcarnitine causes analgesia in mice modeling Fabry disease by up-regulating type-2 metabotropic glutamate receptors

Molecular Pain, 2022
Fabry disease (FD) is a X-linked lysosomal storage disorder caused by deficient function of the alpha-galactosidase A (α-GalA) enzyme. α-GalA deficiency leads to multisystemic clinical manifestations caused by the preferential accumulation of ...
Francesco Formaggio, R. Rimondini, C. Delprete, Leonardo Scalia, E. Merlo Pich, R. Liguori, F. Nicoletti, M. Caprini   +7 more
semanticscholar   +1 more source

Acetylcarnitine metabolism in blowfly flight muscle mitochondria [PDF]

FEBS Letters, 1975
Carnitine is involved in the movement of acetylCOA and fatty acyl-CoA into the matrices of mammalian mitochondria, where they are oxidized [ 1 ] . In some insects, carnitine may have a different role. Blowfly flight muscle mitochondria will not oxidize palmitoylcarnitine as they do not contain the enzymes for fatty acid oxidation [2,3], and they cannot
Danks, Susan M., Chappell, J.B.
openaire   +2 more sources

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

American Journal of Clinical Nutrition, 2020
Background Nicotinamide riboside (NR) is an NAD+ precursor that boosts cellular NAD+ concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation.
Carlijn M. E. Remie, K. Roumans, Michiel P B Moonen, N. J. Connell, B. Havekes, J. Mevenkamp, L. Lindeboom, Vera H. W. de Wit, T. van de Weijer, S. Aarts, E. Lutgens, B. Schomakers, H. Elfrink, R. Zapata-Pérez, R. Houtkooper, J. Auwerx, J. Hoeks, V. Schrauwen-Hinderling, E. Phielix, P. Schrauwen   +19 more
semanticscholar   +1 more source

A Multivariate Metabolomics Method for Estimating Platelet Mitochondrial Oxygen Consumption Rates in Patients with Sepsis

Metabolites, 2020
Background: Sepsis-induced alterations in mitochondrial function contribute to organ dysfunction and mortality. Measuring mitochondrial function in vital organs is neither feasible nor practical, highlighting the need for non-invasive approaches ...
Marc R. McCann, Cora E. McHugh, Maggie Kirby, Theodore S. Jennaro, Alan E. Jones, Kathleen A. Stringer, Michael A. Puskarich   +6 more
doaj   +1 more source

Perinatal free carnitine and short chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns in relation to their birth weight

Pediatrics and Neonatology, 2020
Background: Free carnitine (C0) and short chain acylcarnitine (SCA) blood concentrations play a significant role in fatty acid oxidation process during the first days of life.
Penelope D. Manta-Vogli, Kleopatra H. Schulpis, Yannis L. Loukas, Yannis Dotsikas   +3 more
doaj   +1 more source

Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?☆ [PDF]

Advanced Drug Delivery Reviews, 2009
Endogenous acetylcarnitine is an indicator of acetyl-CoA synthesized by multiple metabolic pathways involving carbohydrates, amino acids, fatty acids, sterols, and ketone bodies, and utilized mainly by the tricarboxylic acid cycle. Acetylcarnitine supplementation has beneficial effects in elderly animals and humans, including restoration of ...
Mariana G, Rosca, Hélène, Lemieux, Charles L, Hoppel   +2 more
openaire   +2 more sources

Stable isotope-labeled carnitine reveals its rapid transport into muscle cells and acetylation during contraction

Heliyon, 2023
Carnitine plays multiple roles in skeletal muscle metabolism, including fatty acid transport and buffering of excess acetyl-CoA in the mitochondria. The skeletal muscle cannot synthesize carnitine; therefore, carnitine must be taken up from the blood ...
Yasuro Furuichi, Naoko Goto-Inoue, Saki Uchida, Shun Masuda, Yasuko Manabe, Nobuharu L. Fujii   +5 more
doaj   +1 more source

Role of carnitine acetylation in skeletal muscle

Journal of Physical Fitness and Sports Medicine, 2014
Carnitine is known for its role in the transport of long-chain fatty acids into the mitochondrial matrix for subsequent β-oxidation. In addition, carnitine acts as an acceptor of excess acetyl-CoA and forms acetylcarnitine to relieve inhibition of ...
Yasuro Furuichi, Naoko Goto-Inoue, Nobuharu L. Fujii   +2 more
doaj   +1 more source