Results 31 to 40 of about 9,200 (244)

Application of Metabolomics to Identify Potential Biomarkers for the Early Diagnosis of Coronary Heart Disease

Frontiers in Physiology, 2021
Coronary heart disease (CHD) is one of the leading causes of deaths globally. Identification of serum metabolic biomarkers for its early diagnosis is thus much desirable.
Huali Jiang, Huali Jiang, Li Li, Weijie Chen, Benfa Chen, Heng Li, Shanhua Wang, Min Wang, Yi Luo, Yi Luo   +9 more
doaj   +1 more source

Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]

, 2016
Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R, Guidotti, Alessandro, MATRISCIANO, FRANCESCO, NICOLETTI, Ferdinando, PANACCIONE, ISABELLA   +4 more
core   +2 more sources

An improved and simplified radioisotopic assay for the determination of free and esterified carnitine

Journal of Lipid Research, 1976
The radioisotopic assay for carnitine first described by Cederblad and Lindstedt (Clin. Chim. Acta. 37:235–543, 1972) and modified by Bøhmer et al (Clin. Chim. Acta. 57:55–61, 1974) has been improved and simplified. As a result, the assay yields a linear
J D McGarry, D W Foster
doaj   +1 more source

Levocarnitine for the Treatment of Polymorbid Patients

Рациональная фармакотерапия в кардиологии, 2020
Effective and safe treatment of patients with polymorbidity is an urgent task of modern healthcare. Of particular difficulty is the treatment of patients with cardiovascular comorbidity, which requires an integrated approach to the treatment and ...
A. P. Pereverzev, D. A. Shevchenko, A. V. Filippova, A. A. Kirichenko, I. F. Krotkova, O. D. Ostroumova   +5 more
doaj   +1 more source

Database screening as a strategy to identify endogenous candidate metabolites to probe and assess mitochondrial drug toxicity

Scientific Reports, 2023
Adverse drug reactions (ADRs) are considered an inherent risk of medication use, and some ADRs have been associated with off-target drug interactions with mitochondria. Metabolites that reflect mitochondrial function may help identify patients at risk of
Mery Vet George De la Rosa, Dipali Patel, Marc R. McCann, Kathleen A. Stringer, Gus R. Rosania   +4 more
doaj   +1 more source

Does canine inflammatory bowel disease influence gut microbial profile and host metabolism? [PDF]

, 2016
Background: Inflammatory bowel disease (IBD) refers to a diverse group of chronic gastrointestinal diseases, and gut microbial dysbiosis has been proposed as a modulating factor in its pathogenesis.
Bosch, Guido, Eeckhaut, Venessa, Hesta, Myriam, Janssens, Geert, Junius, Greet, Liu, Daisy, Niu, Yufeng, Ribeiro Alves Lourenço, Marta, Van de Maele, Isabel, Van de Wiele, Tom, Van Immerseel, Filip, Verbrugghe, Adronie, Wuyts, Brigitte, Xu, Jia   +13 more
core   +2 more sources

Impact of L-carnitine in narcolepsy treatment: a systematic review on the effectiveness and safety [PDF]

Sleep Science
Introduction: Studies have shown that narcolepsy patients may present with low serum acylcarnitine levels, demonstrating a dysfunctional beta fatty acid oxidation pathway in these patients.
Cristina Salles, Maria Clara Freitas, Miguel Meira e Cruz   +2 more
doaj   +1 more source

Potential Diagnostic Biomarker Detection for Prostate Cancer Using Untargeted and Targeted Metabolomic Profiling

Current Issues in Molecular Biology, 2023
Prostate cancer (PCa) remains one of the leading causes of cancer mortality in men worldwide, currently lacking specific, early detection and staging biomarkers.
Diana Nitusca, Carmen Socaciu, Andreea Iulia Socaciu, Ioan Ovidiu Sirbu, Razvan Bardan, Alin Adrian Cumpanas, Edward Seclaman, Catalin Marian   +7 more
doaj   +1 more source

Inadvertent intrathecal drug injection while treating low back pain: a case report and review of the literature

Journal of Medical Case Reports, 2023
Background Undesired intrathecal injections represent an important subset of medical errors, albeit rare. Clinical effects depend on the type and concentration of drug(s) injected.
Alessandro Ferrieri, Donatella Bosco, Ennio Polilli, Raffaella Ciulli, Lina Visocchi, Lucrezia Mincione, Rosa Iacoe, Rosamaria Zocaro, Antonella Frattari   +8 more
doaj   +1 more source

Muscle‐Specific Relation of Acetylcarnitine and Intramyocellular Lipids to Chronic Hyperglycemia: A Pilot 3‐T 1H MRS Study

Obesity, 2020
Acetylcarnitine plays an important role in fat metabolism and can be detected in proton magnetic resonance spectra in skeletal muscle. An inverse relationship of acetylcarnitine to intramyocellular lipids and metabolic markers of chronic hyperglycemia ...
Radka Klepochová, M. Leutner, Magdalena Bastian, M. Krebs, Michael Weber, S. Trattnig, A. Kautzky-Willer, M. Krššák   +7 more
semanticscholar   +1 more source