Results 91 to 100 of about 2,693 (199)
Beyond Bulk: Cell‐Type‐Resolved Epigenomics as the Path Forward in Alzheimer's Disease Research
European Journal of Neuroscience, Volume 64, Issue 5, September 2026.Alzheimer's disease affects multiple brain cell types through distinct epigenetic mechanisms. Although bulk analyses obscure these cell‐type‐specific changes, cell sorting and single‐cell epitranscriptomic approaches provide the resolution needed to uncover and understand epigenetic dysregulation at the cell‐type level in AD.
Lucía Cañizares‐Moscato +3 more
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 18, Page 7539-7558, 15 September 2026.Abstract figure legend Hypoxia‐inducible factor‐1a (HIF1a) integrates physiological and pathological inputs in skeletal muscle, including exercise, circadian timing, cytotoxins and disease. These inputs alter mitochondrial oxidative function, redox state, reactive oxygen species, and local oxygen availability, leading to intermittent or sustained HIF1a
Nicole Welch +6 more
wiley +1 more source
Global acetylome profiling indicates EPA impedes but OA promotes prostate cancer motility through altered acetylation of PFN1 and FLNA. [PDF]
Prostate cancer (PCa) is one of the leading causes of cancer morbidity and mortality in men. Metastasis is the main cause of PCa-associated death.
Qi, Manting +6 more
core +1 more source
, 2022 Protein lysine acetylation is an evolutionarily conserved post-translational modification (PTM), which is dynamic and reversible, playing a crucial regulatory role in almost every aspect of metabolism, of both eukaryotes and prokaryotes.
Fuyuan Zeng (10101388) +8 more
core +1 more source
Cell Reports, 2015 N-terminal acetylation is a major and vital protein modification catalyzed by N-terminal acetyltransferases (NATs). NatF, or Nα-acetyltransferase 60 (Naa60), was recently identified as a NAT in multicellular eukaryotes.
Henriette Aksnes +15 more
doaj +1 more source
Diet-induced changes in mouse liver proteome, acetylome, and succinylome.
, 2018 a, Schematic of the dietary conditions, sample preparation, and analysis workflow. Five mice from each dietary cohort were sacrificed and a portion of liver tissue was used for quantification of organic and amino acids.
Bradford W. Gibson (160688) +9 more
core +1 more source
Distinct roles for H4 and H2A.Z acetylation in RNA transcription in African trypanosomes
Nature Communications, 2020 Histone modification and deposition are key regulators of transcription. Here, Kraus et al. provide a quantitative histone acetylome for Trypanosoma brucei, identify histone modifications enriched at transcription start sites, and show how H4 and H2A.Z ...
Amelie J. Kraus +5 more
doaj +1 more source
New Phytologist, Volume 251, Issue 1, Page 321-339, July 2026.Summary We discovered a previously uncharacterized moss‐specific protein, Rosetta NATD‐MAPK 1 (RAK1) in Physcomitrium patens, which uniquely integrates MAP kinase (MAPK)‐dependent signaling with N‐acetyltransferase activity. Through phenotypical and biochemical analyses, we characterized RAK1 function in the regulation of the 2D‐to‐3D growth transition.
Cloe de Luxán‐Hernández +17 more
wiley +1 more source
Integrative Proteome and Acetylome Analyses of Murine Responses to Cryptococcus neoformans Infection
Frontiers in Microbiology, 2020 Cryptococcus neoformans is a causative agent for pulmonary infection and meningoencephalitis. Understanding the host’s response to C. neoformans infection is critical for developing effective treatment.
Hailong Li +8 more
doaj +1 more source
, 2022 Protein lysine acetylation is an evolutionarily conserved post-translational modification (PTM), which is dynamic and reversible, playing a crucial regulatory role in almost every aspect of metabolism, of both eukaryotes and prokaryotes.
Fuyuan Zeng (10101388) +8 more
core +1 more source