Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway [PDF]
CellsThe reciprocal modulation between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway plays a crucial role in the progression of various diseases and neoplasms. Activation of the CXCL12/CXCR4/ACKR3 axis triggers the STAT3 pathway through multiple
Zelong Ma +3 more
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Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells.
PLoS ONE, 2023 Atypical chemokine receptor 3 (ACKR3) is a scavenger of the chemokines CXCL11 and CXCL12 and of several opioid peptides. Additional evidence indicates that ACKR3 binds two other non-chemokine ligands, namely the peptide hormone adrenomedullin (AM) and ...
Elena C Sigmund +7 more
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ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury
Nature Communications, 2022 ACKR3 is a critical regulator of platelet-mediated thrombosis and organ injury following ischemia/reperfusion. Platelet ACKR3 surface expression is independently associated with all-cause mortality in patients with cardiovascular diseases.
Anne-Katrin Rohlfing +42 more
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ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production [PDF]
Frontiers in Immunology, 2023 Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers.
Paola Antonello +10 more
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Heterogeneous expression of the atypical chemokine receptor ACKR3 in glioblastoma patient-derived tissue samples and cell cultures [PDF]
Scientific ReportsGlioblastoma (GBM) is the most aggressive glial tumor of the adult brain, associated with invariably fatal outcome, and a deeper understanding of the underlying malignant mechanisms is necessary to address the current therapeutic failure.
Damla Isci +9 more
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Quantification of increased biologically active CXCL12α plasma concentrations after ACKR3 antagonist treatment in humans [PDF]
Clinical and Translational ScienceCXCL12 acts as a chemoattractant by binding to the receptor CXCR4. The (atypical) chemokine receptor ACKR3 (CXCR7) scavenges CXCL12. Antagonism of ACKR3 thus leads to an increase in CXCL12 concentrations that has been used as a pharmacodynamic biomarker ...
Peter Blattmann +10 more
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Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies [PDF]
Nature CommunicationsStimulation of atypical chemokine receptor 3 (ACKR3) by chemokines does not activate G proteins but recruits arrestin. It is a chemokine scavenger that indirectly influences responses by restricting the availability of CXCL12, an agonist shared with the ...
Claudia V. Perez Almeria +19 more
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D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling [PDF]
EBioMedicine, 2021 Background: Emphysematous COPD is characterized by aberrant alveolar repair. Macrophage migration inhibitory factor (MIF) contributes to alveolar repair, but for its structural and functional homolog D-dopachrome tautomerase (DDT) this is unknown.
Shanshan Song +11 more
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Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes [PDF]
eLifeThe canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell migration.
Christopher T Schafer +4 more
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Structural basis of ligand interaction with atypical chemokine receptor 3 [PDF]
Nature Communications, 2017 The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer. Here the authors combine radiolytic footprinting, disulfide trapping, mutagenesis and molecular modelling to characterize the ligand interactions and ...
Martin Gustavsson +10 more
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