Results 1 to 10 of about 3,096 (131)

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies [PDF]

Nature Communications
Stimulation of atypical chemokine receptor 3 (ACKR3) by chemokines does not activate G proteins but recruits arrestin. It is a chemokine scavenger that indirectly influences responses by restricting the availability of CXCL12, an agonist shared with the ...
Claudia V. Perez Almeria, Omolade Otun, Roman Schlimgen, Thomas D. Lamme, Lotte Di Niro, Caitrin Crudden, Jan Paul Bebelman, Noureldine Youssef, Lejla Musli, Shawn Jenjak, Vladimir Bobkov, Julia Drube, Carsten Hoffmann, Brian F. Volkman, Sébastien Granier, Cherine Bechara, Marco Siderius, Raimond Heukers, Christopher T. Schafer, Martine J. Smit   +19 more
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D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling [PDF]

EBioMedicine, 2021
Background: Emphysematous COPD is characterized by aberrant alveolar repair. Macrophage migration inhibitory factor (MIF) contributes to alveolar repair, but for its structural and functional homolog D-dopachrome tautomerase (DDT) this is unknown.
Shanshan Song, Bin Liu, Habibie Habibie, Jelle van den Bor, Martine J. Smit, Reinoud Gosens, Xinhui Wu, Corry-Anke Brandsma, Robbert H. Cool, Hidde J. Haisma, Gerrit J. Poelarends, Barbro N. Melgert   +11 more
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ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production [PDF]

Frontiers in Immunology, 2023
Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers.
Paola Antonello, Paola Antonello, Diego U. Pizzagalli, Diego U. Pizzagalli, Mathilde Foglierini, Mathilde Foglierini, Serena Melgrati, Serena Melgrati, Egle Radice, Sylvia Thelen, Marcus Thelen   +10 more
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Structural basis of ligand interaction with atypical chemokine receptor 3 [PDF]

Nature Communications, 2017
The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer. Here the authors combine radiolytic footprinting, disulfide trapping, mutagenesis and molecular modelling to characterize the ligand interactions and ...
Martin Gustavsson, Liwen Wang, Noortje van Gils, Bryan S. Stephens, Penglie Zhang, Thomas J. Schall, Sichun Yang, Ruben Abagyan, Mark R. Chance, Irina Kufareva, Tracy M. Handel   +10 more
doaj   +3 more sources

Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes [PDF]

eLife
The canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell migration.
Christopher T Schafer, Raymond F Pauszek III, Martin Gustavsson, Tracy M Handel, David P Millar   +4 more
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TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers [PDF]

Communications Biology
Chemokine receptors CXCR4 and ACKR3 are involved in multiple physiological and pathological processes. In overexpression systems, CXCR4 and ACKR3 form oligomers that are important for chemokine recognition and signaling.
Joyce Heuninck, Vladimir Bobkov, Claire M. Grison, Amos Fumagalli, Mathias Lescuyer, Omolade Otun, Cherine Bechara, Laurent Lamarque, Eric Trinquet, Françoise Bachelerie, Philippe Marin, Bernard Mouillac, Sébastien Granier, Bas van der Woning, Hans de Haard, Martine J. Smit, Raimond Heukers, Thierry Durroux   +17 more
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Heterogeneous expression of the atypical chemokine receptor ACKR3 in glioblastoma patient-derived tissue samples and cell cultures [PDF]

Scientific Reports
Glioblastoma (GBM) is the most aggressive glial tumor of the adult brain, associated with invariably fatal outcome, and a deeper understanding of the underlying malignant mechanisms is necessary to address the current therapeutic failure.
Damla Isci, Amandine Kuppens, Joshua Scalisi, Julie Cokaiko, Giulia D’Uonnolo, May Wantz, Martyna Szpakowska, Andy Chevigné, Bernard Rogister, Virginie Neirinckx   +9 more
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CXCR7 is highly expressed in acute lymphoblastic leukemia and potentiates CXCR4 response to CXCL12. [PDF]

PLoS ONE, 2014
Recently, a novel CXCL12-binding receptor, has been identified. This CXCL12-binding receptor commonly known as CXCR7 (CXC chemokine receptor 7), has lately, based on a novel nomenclature, has received the name ACKR3 (atypical chemokine receptor 3).
Rita de Cássia Carvalho Melo, Ana Leda Longhini, Carolina Louzão Bigarella, Mariana Ozello Baratti, Fabiola Traina, Patrícia Favaro, Paula de Melo Campos, Sara Teresinha Olalla Saad   +7 more
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Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases [PDF]

Arthritis Research & Therapy
Background The C-X-C motif chemokine 12 (CXCL12) and its receptor CXCR4 are pivotal in tissue regeneration and inflammation, yet their role in osteoarthritis (OA) remains ambiguous.
Leonie Ruths, Hannah de Hesselle, Felix Haußner, Sofya Albers, Mirja Harms, Tobias Freitag, Jan Münch, Jana Riegger   +7 more
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Atlas of the anatomical localization of atypical chemokine receptors in healthy mice. [PDF]

PLoS Biology, 2023
Atypical chemokine receptors (ACKRs) scavenge chemokines and can contribute to gradient formation by binding, internalizing, and delivering chemokines for lysosomal degradation.
Serena Melgrati, Egle Radice, Rafet Ameti, Elin Hub, Sylvia Thelen, Pawel Pelczar, David Jarrossay, Antal Rot, Marcus Thelen   +8 more
doaj   +3 more sources