Results 111 to 120 of about 3,165 (181)

Changes in epithelial proportions and transcriptional state underlie major premenopausal breast cancer risks [PDF]

, 2018
The human breast undergoes lifelong remodeling in response to estrogen and progesterone, but hormone exposure also increases breast cancer risk. Here, we use single-cell analysis to identify distinct mechanisms through which breast composition and cell ...
Borowsky, Alexander D., Caruso, Joseph A., Desai, Tejal A., Gartner, Zev J., Gascard, Philippe, McGinnis, Christopher S., Murrow, Lyndsay M., Phong, Kiet, Thomson, Matthew, Tlsty, Thea, Weber, Robert J.   +10 more
core   +1 more source

The atypical receptor CCRL2 (C-C Chemokine Receptor-Like 2) does not act as a decoy receptor in endothelial cells [PDF]

, 2017
C-C chemokine receptor-like 2 (CCRL2) is a non-signaling seven-transmembrane domain (7-TMD) receptor related to the atypical chemokine receptor (ACKR) family.
Annalisa Del Prete, Annalisa Del Prete, Chiara Mazzotti, Daniela Bosisio, Laura Tiberio, Marcus Thelen, Silvano Sozzani, Silvano Sozzani, Vincenzo Gagliostro   +8 more
core   +3 more sources

CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm [PDF]

Binocular vision requires the segregation of retinal ganglion cell (RGC) axons extending from the retina into the ipsilateral and contralateral optic tracts. RGC axon segregation occurs at the optic chiasm, which forms at the ventral diencephalon midline.
Denti, Laura, Erskine, Lynda, Le, Viet-Hang, Murcia-Belmonte, Verónica, Orniacki, Clarisse, Ruhrberg, Christiana, Schütz, Dagmar, Stumm, Ralf   +7 more
core   +4 more sources

Quantification of increased biologically active CXCL12α plasma concentrations after ACKR3 antagonist treatment in humans

Clinical and Translational Science
CXCL12 acts as a chemoattractant by binding to the receptor CXCR4. The (atypical) chemokine receptor ACKR3 (CXCR7) scavenges CXCL12. Antagonism of ACKR3 thus leads to an increase in CXCL12 concentrations that has been used as a pharmacodynamic biomarker ...
Peter Blattmann, Hervé Farine, Brian Dan, Nicole Stiffler, Thomas Lefebvre, Christine Huynh, Patricia N. Sidharta, Jasper Dingemanse, Richard W. D. Welford, Marcel Keller, Daniel S. Strasser   +10 more
doaj   +1 more source

Targeting the Atypical Chemokine Receptor ACKR3/CXCR7 for the treatment of cancer and other diseases [PDF]

, 2015
One of the greatest challenges in fighting cancer is cell targeting and biomarker selection. The Atypical Chemokine Receptor ACKR3/CXCR7 is expressed on many cancer cell types, including breast cancer and glioblastoma, and binds the endogenous ligands ...
NC DOCKS at The University of North Carolina at Greensboro, Vestal, Richard D.   +1 more
core  

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source

Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring.

Development
ABSTRACT ACKR3 scavenges and degrades the stem cell recruiting chemokine CXCL12, which is essential for proper embryonic and, in particular, haematopoietic development. Here, we demonstrate strong expression of ACKR3 on trophoblasts.
Fukuoka A, Wilson GJ, Pitmon E, Koumbas Foley L, Johnsson H, Pingen M, Graham GJ.   +6 more
europepmc   +3 more sources

ELUCIDATE ACKR3 EXPRESSION AND FUNCTION IN GLIOBLASTOMA-ASSOCIATED MICROENVIRONMENT

Neuro-Oncology
Abstract AIMS Glioblastoma is the most prevalent primary brain tumor in adults, leading to a grim prognosis. The development of efficient therapies is limited by several factors, including the immunosuppressive tumor microenvironment.
Kuppens, Miss Amandine, Leurs, Rob, Szpakowska, Martyna, Chevigné, Andy, Rogister, Bernard, Neirinckx, Virginie   +5 more
openaire   +1 more source

ACKR3 in Health and Disease

Introduced in Chapter 1, Cxcl12 and Cxcr4 play crucial roles during development, adult life and pathophysiology, in particular in hematopoiesis, inflammatory disease and cancer progression. Hematopoiesis relies on a complex interplay between hematopoietic cells and supporting stromal cells within specialized bone marrow (BM) niches.
openaire   +2 more sources

Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats.

PLoS ONE, 2019
This work extends the understanding of how toxic exposures to amphetamine (AMPH) adversely affect the immune system and lead to tissue damage. Importantly, it determines which effects of AMPH are and are not due to pronounced hyperthermia.
Luísa Camacho, Camila S Silva, Joseph P Hanig, Robert P Schleimer, Nysia I George, John F Bowyer   +5 more
doaj   +1 more source