Results 11 to 20 of about 3,455 (202)

Emerging Roles of the Atypical Chemokine Receptor 3 (ACKR3) in Cardiovascular Diseases

Frontiers in Endocrinology, 2022
Chemokines, and their receptors play a crucial role in the pathophysiology of cardiovascular diseases (CVD). Chemokines classically mediate their effects by binding to G-protein-coupled receptors.
Vincent Duval, Paul Alayrac, Jean-Sébastien Silvestre, Angélique Levoye, Angélique Levoye   +4 more
doaj   +4 more sources

Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3). [PDF]

ACS Med Chem Lett, 2023
The atypical chemokine receptor 3 (ACKR3) is a receptor that induces cancer progression and metastasis in multiple cell types. Therefore, new chemical tools are required to study the role of ACKR3 in cancer and other diseases.
Dekkers S, Comez D, Karsai N, Arimont-Segura M, Canals M, Caspar B, de Graaf C, Kilpatrick LE, Leurs R, Kellam B, Hill SJ, Briddon SJ, Stocks MJ.   +12 more
europepmc   +4 more sources

Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring.

Development
ACKR3 scavenges and degrades the stem cell recruiting chemokine CXCL12, which is essential for proper embryonic and, in particular, haematopoietic development. Here, we demonstrate strong expression of ACKR3 on trophoblasts.
Fukuoka A, Wilson GJ, Pitmon E, Koumbas Foley L, Johnsson H, Pingen M, Graham GJ.   +6 more
europepmc   +4 more sources

Marginal Zone Formation Requires ACKR3 Expression on B Cells

Cell Reports, 2020
Summary: The marginal zone (MZ) contributes to the highly organized spleen microarchitecture. We show that expression of atypical chemokine receptor 3 (ACKR3) defines two equal-sized populations of mouse MZ B cells (MZBs).
Egle Radice, Rafet Ameti, Serena Melgrati, Mathilde Foglierini, Paola Antonello, Rolf A.K. Stahl, Sylvia Thelen, David Jarrossay, Marcus Thelen   +8 more
doaj   +3 more sources

Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue

Biomedicines, 2021
Dysfunctional adipose tissue (AT) may contribute to the pathology of several metabolic diseases through altered lipid metabolism, insulin resistance, and inflammation.
Selin Gencer, Yvonne Döring, Yvonne Jansen, Soyolmaa Bayasgalan, Olga Schengel, Madeleine Müller, Linsey J. F. Peters, Christian Weber, Emiel P. C. van der Vorst   +8 more
doaj   +7 more sources

Ackr3-Venus knock-in mouse lights up brain vasculature [PDF]

Molecular Brain, 2021
The atypical chemokine receptor 3, ACKR3, is a G protein-coupled receptor, which does not couple to G proteins but recruits βarrestins. At present, ACKR3 is considered a target for cancer and cardiovascular disorders, but less is known about the ...
Aliza T. Ehrlich, Meriem Semache, Pierre Couvineau, Stefan Wojcik, Hiroyuki Kobayashi, Marcus Thelen, Florence Gross, Mireille Hogue, Christian Le Gouill, Emmanuel Darcq, Michel Bouvier, Brigitte L. Kieffer   +11 more
doaj   +5 more sources

ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin [PDF]

Cell Reports, 2019
Summary: Phosphorylation of heptahelical receptors is thought to regulate G protein signaling, receptor endocytosis, and non-canonical signaling via recruitment of β-arrestins.
Friederike Saaber, Dagmar Schütz, Elke Miess, Philipp Abe, Srinidhi Desikan, Praveen Ashok Kumar, Sara Balk, Ke Huang, Jean Martin Beaulieu, Stefan Schulz, Ralf Stumm   +10 more
doaj   +3 more sources

ACKR3 agonism induces heterodimerization with chemokine receptor CXCR4 and attenuates platelet function. [PDF]

Eur J Clin Invest
Background Platelet receptors ACKR3 and CXCR4 play a crucial role in a variety of cardio-vascular diseases. Like most chemokine receptors, CXCR4 is a G protein coupled receptor that induces platelet activation.
Dicenta-Baunach V, Laspa Z, Schaale D, Sigle M, Bayrak A, Castor T, Pillaiyar T, Laufer S, Gawaz MP, Rohlfing AK.   +9 more
europepmc   +2 more sources

Circulating hsa_circ_0072309, acting via the miR‐100/ACKR3 pathway, maybe a potential biomarker for the diagnosis, prognosis, and treatment of brain metastasis from non‐small‐cell lung cancer

Cancer Medicine, 2023
Background One of the main causes of lung cancer‐related death is brain metastasis (BM). Finding early indicators of BM derived from lung cancer is crucial.
Xiao‐Qiang Zhang, Qian Song, Lin‐Xiang Zeng   +2 more
doaj   +2 more sources

Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology [PDF]

Cells, 2022
The manifold actions of the pro-inflammatory and regenerative chemokine CXCL12/SDF-1α are executed through the canonical GProteinCoupledReceptor CXCR4, and the non-canonical ACKR3/CXCR7.
Madhumita Chatterjee
doaj   +4 more sources