Results 11 to 20 of about 3,165 (181)
Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway [PDF]
CellsThe reciprocal modulation between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway plays a crucial role in the progression of various diseases and neoplasms. Activation of the CXCL12/CXCR4/ACKR3 axis triggers the STAT3 pathway through multiple
Zelong Ma +3 more
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Marginal Zone Formation Requires ACKR3 Expression on B Cells
Cell Reports, 2020 Summary: The marginal zone (MZ) contributes to the highly organized spleen microarchitecture. We show that expression of atypical chemokine receptor 3 (ACKR3) defines two equal-sized populations of mouse MZ B cells (MZBs).
Egle Radice +8 more
doaj +3 more sources
Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue
Biomedicines, 2021 Dysfunctional adipose tissue (AT) may contribute to the pathology of several metabolic diseases through altered lipid metabolism, insulin resistance, and inflammation.
Selin Gencer +8 more
doaj +7 more sources
Ackr3-Venus knock-in mouse lights up brain vasculature [PDF]
Molecular Brain, 2021 The atypical chemokine receptor 3, ACKR3, is a G protein-coupled receptor, which does not couple to G proteins but recruits βarrestins. At present, ACKR3 is considered a target for cancer and cardiovascular disorders, but less is known about the ...
Aliza T. Ehrlich +11 more
doaj +5 more sources
Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells.
PLoS ONE, 2023 Atypical chemokine receptor 3 (ACKR3) is a scavenger of the chemokines CXCL11 and CXCL12 and of several opioid peptides. Additional evidence indicates that ACKR3 binds two other non-chemokine ligands, namely the peptide hormone adrenomedullin (AM) and ...
Elena C Sigmund +7 more
doaj +6 more sources
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury
Nature Communications, 2022 ACKR3 is a critical regulator of platelet-mediated thrombosis and organ injury following ischemia/reperfusion. Platelet ACKR3 surface expression is independently associated with all-cause mortality in patients with cardiovascular diseases.
Anne-Katrin Rohlfing +42 more
doaj +4 more sources
ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin [PDF]
Cell Reports, 2019 Summary: Phosphorylation of heptahelical receptors is thought to regulate G protein signaling, receptor endocytosis, and non-canonical signaling via recruitment of β-arrestins.
Friederike Saaber +10 more
doaj +3 more sources
The CXCL12/CXCR4/ACKR3 Signaling Axis Regulates PKM2 and Glycolysis
Cells, 2022 In response to CXCL12, CXCR4 and ACKR3 both recruit β-arrestin 2, regulating the assembly of interacting proteins that drive signaling and contribute to the functions of both receptors in cancer and multiple other diseases.
Kathryn E. Luker, Gary D. Luker
doaj +3 more sources
Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology [PDF]
Cells, 2022 The manifold actions of the pro-inflammatory and regenerative chemokine CXCL12/SDF-1α are executed through the canonical GProteinCoupledReceptor CXCR4, and the non-canonical ACKR3/CXCR7.
Madhumita Chatterjee
doaj +4 more sources
The role of ACKR3 in breast, lung, and brain cancer [PDF]
Molecular Pharmacology, 2020 Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on atypical chemokine receptor 3 (ACKR3). This atypical chemokine receptor is overexpressed in numerous cancer types and has been involved in the modulation ...
Fumagalli, Amos +5 more
core +6 more sources