Results 21 to 30 of about 3,455 (202)

The CXCL12/CXCR4/ACKR3 Signaling Axis Regulates PKM2 and Glycolysis

Cells, 2022
In response to CXCL12, CXCR4 and ACKR3 both recruit β-arrestin 2, regulating the assembly of interacting proteins that drive signaling and contribute to the functions of both receptors in cancer and multiple other diseases.
Kathryn E. Luker, Gary D. Luker
doaj   +3 more sources

TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers [PDF]

Communications Biology
Chemokine receptors CXCR4 and ACKR3 are involved in multiple physiological and pathological processes. In overexpression systems, CXCR4 and ACKR3 form oligomers that are important for chemokine recognition and signaling.
Joyce Heuninck, Vladimir Bobkov, Claire M. Grison, Amos Fumagalli, Mathias Lescuyer, Omolade Otun, Cherine Bechara, Laurent Lamarque, Eric Trinquet, Françoise Bachelerie, Philippe Marin, Bernard Mouillac, Sébastien Granier, Bas van der Woning, Hans de Haard, Martine J. Smit, Raimond Heukers, Thierry Durroux   +17 more
doaj   +2 more sources

The role of ACKR3 in breast, lung, and brain cancer [PDF]

Molecular Pharmacology, 2020
Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on atypical chemokine receptor 3 (ACKR3). This atypical chemokine receptor is overexpressed in numerous cancer types and has been involved in the modulation ...
Fumagalli, Amos, Marin, Philippe, Mayor Méndez, Federico Jr., Neves, María, Smit, Martine J., Van den Bor, Jelle   +5 more
core   +6 more sources

Hemin-induced platelet activation is regulated by the ACKR3 chemokine surface receptor and has implications for passivation of vulnerable atherosclerotic plaques. [PDF]

FEBS J
In vulnerable atherosclerotic plaques, intraplaque hemorrhages (IPH) result in hemolysis of red blood cells and release of hemoglobin and free hemin. Hemin activates platelets and leads to thrombosis.
Laspa Z, Dicenta-Baunach V, Schaale D, Sigle M, Hochuli R, Castor T, Bayrak A, Harm T, Müller KAL, Pillaiyar T, Laufer S, Rohlfing AK, Gawaz MP.   +12 more
europepmc   +2 more sources

Crosstalk between CXCR4/ACKR3 and EGFR signaling in breast cancer cells [PDF]

International Journal of Molecular Sciences, 2022
A better understanding of the complex crosstalk among key receptors and signaling pathways involved in cancer progression is needed to improve current therapies.
Marolda, Viviana, Mayor Menéndez, Federico, Neves, Maria, Penela Márquez, Petronila   +3 more
core   +6 more sources

Modulators of CXCR4 and CXCR7/ACKR3 Function [PDF]

Molecular Pharmacology, 2019
Copyright © 2019 by The Author(s). The two G protein-coupled receptors (GPCRs) C-X-C chemokine receptor type 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are part of the class A chemokine GPCR family and represent important drug targets for human ...
Adlere, Ilze, Arimont, Marta, Briddon, Stephen, Caspar, Birgit, de Esch, Iwan, de Graaf, Chris, Dekkers, Sebastian, Hill, Stephen, Kellam, Barrie, Leurs, Rob, Stocks, Michael, Stuijt, Jeffrey, Visser, Kirsten, Wijtmans, Maikel   +13 more
core   +7 more sources

Atlas of the anatomical localization of atypical chemokine receptors in healthy mice. [PDF]

PLoS Biology, 2023
Atypical chemokine receptors (ACKRs) scavenge chemokines and can contribute to gradient formation by binding, internalizing, and delivering chemokines for lysosomal degradation.
Serena Melgrati, Egle Radice, Rafet Ameti, Elin Hub, Sylvia Thelen, Pawel Pelczar, David Jarrossay, Antal Rot, Marcus Thelen   +8 more
doaj   +2 more sources

Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases [PDF]

Arthritis Research & Therapy
Background The C-X-C motif chemokine 12 (CXCL12) and its receptor CXCR4 are pivotal in tissue regeneration and inflammation, yet their role in osteoarthritis (OA) remains ambiguous.
Leonie Ruths, Hannah de Hesselle, Felix Haußner, Sofya Albers, Mirja Harms, Tobias Freitag, Jan Münch, Jana Riegger   +7 more
doaj   +2 more sources

CXCR7 is highly expressed in acute lymphoblastic leukemia and potentiates CXCR4 response to CXCL12. [PDF]

PLoS ONE, 2014
Recently, a novel CXCL12-binding receptor, has been identified. This CXCL12-binding receptor commonly known as CXCR7 (CXC chemokine receptor 7), has lately, based on a novel nomenclature, has received the name ACKR3 (atypical chemokine receptor 3).
Rita de Cássia Carvalho Melo, Ana Leda Longhini, Carolina Louzão Bigarella, Mariana Ozello Baratti, Fabiola Traina, Patrícia Favaro, Paula de Melo Campos, Sara Teresinha Olalla Saad   +7 more
doaj   +4 more sources

ACKR3 Antagonism Enhances the Repair of Demyelinated Lesions Through Both Immunomodulatory and Remyelinating Effects. [PDF]

Neurochem Res
Addressing inflammation, demyelination, and associated neurodegeneration in inflammatory demyelinating diseases like multiple sclerosis (MS) remains challenging.
Pouzol L, Sassi A, Tunis M, Zurbach A, Baumlin N, Gnerre C, Strasser DS, Marrie J, Vezzali E, Martinic MM.   +9 more
europepmc   +2 more sources