Crosstalk between CXCR4/ACKR3 and EGFR signaling in breast cancer cells [PDF]
International Journal of Molecular Sciences, 2022 A better understanding of the complex crosstalk among key receptors and signaling pathways involved in cancer progression is needed to improve current therapies.
Marolda, Viviana +3 more
core +6 more sources
Emerging Roles of the Atypical Chemokine Receptor 3 (ACKR3) in Cardiovascular Diseases
Frontiers in Endocrinology, 2022 Chemokines, and their receptors play a crucial role in the pathophysiology of cardiovascular diseases (CVD). Chemokines classically mediate their effects by binding to G-protein-coupled receptors.
Vincent Duval +4 more
doaj +3 more sources
Modulators of CXCR4 and CXCR7/ACKR3 Function [PDF]
Molecular Pharmacology, 2019 Copyright © 2019 by The Author(s). The two G protein-coupled receptors (GPCRs) C-X-C chemokine receptor type 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are part of the class A chemokine GPCR family and represent important drug targets for human ...
Adlere, Ilze +13 more
core +7 more sources
GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity [PDF]
Frontiers in Immunology, 2023 Immune responses highly depend on the effective trafficking of immune cells into and within secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge chemokines to eliminate them from the extracellular space, thereby generating ...
Serena Melgrati +16 more
doaj +3 more sources
Modulation of non-canonical CXCR4 and ACKR3 functions [PDF]
The large family of G protein-coupled receptor (GPCR) family transduce extracellular signals via diverse signaling pathways to control physiological functions.
Perez Almeria, Claudia Victoria
core +2 more sources
The discovery of small-molecule modulators for the ACKR3 receptor [PDF]
, 2023 The atypical chemokine receptor 3 (ACKR3) is an attractive drug target for a new generation of chemotherapies. The inhibition of chemokine binding to ACKR3 by small-molecule agonists has shown reduced cancer activity in vivo and in vitro.
Riemens, Rick
core +3 more sources
The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases [PDF]
Frontiers in Endocrinology, 2019 Chemokine receptors are members of the G protein-coupled receptor superfamily. These receptors are intimately involved in cell movement, and thus play a critical role in several physiological and pathological situations that require the precise ...
Eva M. García-Cuesta +5 more
doaj +5 more sources
Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies [PDF]
Nature CommunicationsG protein-coupled receptors (GPCRs) are pivotal therapeutic targets, but their complex structure poses challenges for effective drug design. Nanobodies, or single-domain antibodies, have emerged as a promising therapeutic strategy to target GPCRs ...
Roman R. Schlimgen +5 more
doaj +2 more sources
Single-cell RNA sequencing reveals the potential role of Postn(+) fibroblasts in promoting the progression of myocardial fibrosis after myocardial infarction [PDF]
Scientific ReportsMyocardial infarction (MI) is a life-threatening coronary artery-related pathology characterized by sudden cardiac death, often leading to cardiac fibrosis and heart failure (HF).
Wenyang Nie +6 more
doaj +2 more sources
Single-Cell Transcriptomics Reveals Dynamic Cellular Interactions and Molecular Mechanisms in Myocardial Infarction Recovery. [PDF]
Int J GenomicsBackground Repair and remodeling following myocardial infarction (MI) are complex processes with a wide array of cellular and molecular mechanisms; however, the cell source mediating repair is still poorly understood in terms of heterogeneity and temporal dynamics.
Zhao J, Gong J, Zhu C.
europepmc +2 more sources