Results 61 to 70 of about 3,455 (202)
Chemokines in the balance: Maintenance of homeostasis and protection at CNS barriers [PDF]
, 2014 In the adult central nervous system (CNS), chemokines and their receptors are involved in developmental, physiological and pathological processes. Although most lines of investigation focus on their ability to induce the migration of cells, recent ...
Holman, David W +2 more
core +3 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundRecently, we provided evidence that α1‐adrenergic receptors (ARs) in vascular smooth muscle are regulated by chemokine (C‐X‐C motif) receptor (CXCR) 4 and atypical chemokine receptor 3 (ACKR3). While we showed that CXCR4 controls α1‐ARs through
Lauren J. Albee +7 more
doaj +1 more source
Nature Communications, 2020 The atypical chemokine receptor 3 (ACKR3) is known to regulate cell migration, but the underlying mechanisms are unclear. Here, the authors show, from an interactome analysis, ACKR3 association with the gap junction protein Connexin 43 in vivo and ACKR3 ...
Amos Fumagalli +15 more
doaj +1 more source
From Insight to Modulation of CXCR4 and ACKR3 (CXCR7) Function [PDF]
Molecular Pharmacology, 2019 Chemokine receptors CXCR4 and atypical chemokine receptor 3 (ACKR3/CXCR7) are highly expressed in a range of tumors. Yet, their role in cancer progression is not well understood. This minireview series encompasses seven comprehensive reviews focusing on modulators (small molecules, pepducins, antibodies), structural aspects, spatio-temporal signaling ...
Smit, Martine J. +1 more
openaire +3 more sources
Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. [PDF]
, 2017 Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major ...
Chen, Ying-Jiun J +7 more
core +1 more source
The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]
, 2018 Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi +12 more
core +1 more source
The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]
, 2014 G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F +12 more
core +4 more sources
Glia Cells Control Olfactory Neurogenesis by Fine-Tuning CXCL12
Cells, 2023 Olfaction depends on lifelong production of sensory neurons from CXCR4 expressing neurogenic stem cells. Signaling by CXCR4 depends on the concentration of CXCL12, CXCR4’s principal ligand.
André Dietz +4 more
doaj +1 more source
Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function. [PDF]
PLoS ONE, 2017 Recent evidence suggests that chemokine CXCL12, the cognate agonist of chemokine receptors CXCR4 and ACKR3, reduces thrombin-mediated impairment of endothelial barrier function.
You-Hong Cheng +4 more
doaj +1 more source
Evaluation of Atypical Chemokine Receptor Expression in T Cell Subsets
Cells, 2022 Chemokines are molecules that pertain to a family of small cytokines and can generate cell chemotaxis through the interaction with their receptors.
Messias Oliveira Pacheco +3 more
doaj +1 more source