Results 61 to 70 of about 3,165 (181)

Novel insights into neuroinflammation: bacterial lipopolysaccharide, tumor necrosis factor α, and Ureaplasma species differentially modulate atypical chemokine receptor 3 responses in human brain microvascular endothelial cells

Journal of Neuroinflammation, 2018
Background Atypical chemokine receptor 3 (ACKR3, synonym CXCR7) is increasingly considered relevant in neuroinflammatory conditions, in which its upregulation contributes to compromised endothelial barrier function and may ultimately allow inflammatory ...
Christine Silwedel, Christian P. Speer, Axel Haarmann, Markus Fehrholz, Heike Claus, Mathias Buttmann, Kirsten Glaser   +6 more
doaj   +1 more source

Predicting Autism Spectrum Disorder Using Blood-based Gene Expression Signatures and Machine Learning [PDF]

, 2017
Objective: The aim of this study was to identify a transcriptomic signature that could be used to classify subjects with autism spectrum disorder (ASD) compared to controls on the basis of blood gene expression profiles.
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core   +1 more source

β‐arrestin‐biased ACKR3 Promotes Gαi:β‐arrestin Complex Formation

The FASEB Journal, 2021
Atypical chemokine receptor 3 (ACKR3)—previously known as CXC‐chemokine receptor 7 (CXCR7)—is involved in a wide range of physiological processes including angiogenesis, neuronal development, and tumorigenesis. As a β‐arrestin biased G protein‐coupled receptor (GPCR), ACKR3 recruits β‐arrestin, but lacks G protein activity.
Taylor Kohlmann, Claudia Lee, Sudarshan Rajagopal   +2 more
openaire   +1 more source

Plasticity of seven-transmembrane-helix receptor heteromers in human vascular smooth muscle cells.

PLoS ONE, 2021
Recently, we reported that the chemokine (C-X-C motif) receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) heteromerize with α1A/B/D-adrenoceptors (ARs) and arginine vasopressin receptor 1A (AVPR1A) in recombinant systems and in rodent and human
Lauren J Albee, Xianlong Gao, Matthias Majetschak   +2 more
doaj   +1 more source

EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential

, 2020
Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Here, we investigate how transcriptional changes in bone marrow (BM) MSCs result in long-lasting effects
Cauchy, P., Dereka, M., Grosschedl, R., Grün, D., Herman, J., Lupar, E., Ramamoorthy, S.   +6 more
core   +1 more source

Identification and analysis of mutational hotspots in oncogenes and tumour suppressors [PDF]

, 2017
Background: The key to interpreting the contribution of a disease-associated mutation in the development and progression of cancer is an understanding of the consequences of that mutation both on the function of the affected protein and on the pathways ...
Baeissa, Hanadi, Benstead-Hume, Graeme, Pearl, Frances M G, Richardson, Christopher J   +3 more
core   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, EarlyView.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source

Combining Genome Wide Association Studies and Differential Gene Expression Data Analyses Identifies Candidate Genes Affecting Mastitis Caused by Two Different Pathogens in the Dairy Cow [PDF]

, 2015
Mastitis is a costly disease which hampers the dairy industry. Inflammation of the mammary gland is commonly caused by bacterial infection, mainly Escherichia coli, Streptococcus uberis and Staphylococcus aureus.
Chen, X, Cheng, Z R, Wathes, D C, Werling, D, Zhang, S   +4 more
core   +3 more sources

Development and Validation of a Consensus Machine Learning–Derived Signature to Predict Survival and Treatment Benefits in Breast Cancer

Medicine Advances, Volume 4, Issue 1, Page 61-76, March 2026.
The consensus machine learning–derived prognostic signature (CMDPS) was developed by integrating 10 independent breast cancer cohorts and 76 algorithm combinations, which identified 19 robust survival‐associated genes. The CMDPS demonstrated superior prognostic performance compared to clinical features and 62 published transcriptome signatures ...
Guangyang Cheng, Zhan Wang, Fu Peng, Shuai Yang, Yudi Xu, Hongzhuo Qin, Run Shi, Zhaokai Zhou   +7 more
wiley   +1 more source