Results 71 to 80 of about 3,165 (181)
Frontiers in Immunology, 2023 Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands.
Martyna Szpakowska +10 more
doaj +1 more source
RAMP3 determines rapid recycling of atypical chemokine receptor-3 for guided angiogenesis. [PDF]
, 2019 Receptor-activity-modifying proteins (RAMPs) are single transmembrane-spanning proteins which serve as molecular chaperones and allosteric modulators of G-protein-coupled receptors (GPCRs) and their signaling pathways. Although RAMPs have been previously
Caron, Kathleen M +7 more
core +2 more sources
Inflammatory niches as spatial drivers of disease mechanisms and targets for personalized treatment
Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 423-430, March 2026.This study provides a comprehensive review of how spatial transcriptomics reveals disease‐specific inflammatory niches across multiple skin disorders, highlighting key immune–stromal, neuro–immune and metabolic interactions that were previously unappreciated in non‐spatial analyses. Abstract Disease states are increasingly recognized as being shaped by
Rundong Jiang +3 more
wiley +1 more source
Characterization of a chimeric chemokine as a specific ligand for ACKR3 [PDF]
Journal of Leukocyte Biology, 2018 Abstract Chemokines, small chemotactic cytokines, orchestrate cell migration by binding to their cognate chemokine receptors. While chemokine-mediated stimulation of typical G-protein-coupled chemokine receptors leads to cell migration, binding of chemokines to atypical chemokine receptors (ACKRs) does not induce canonical signaling ...
Ameti, R +7 more
openaire +4 more sources
PLoS ONE, 2018 We observed in PRESTO-Tango β-arrestin recruitment assays that the α1-adrenergic receptor (AR) antagonist prazosin activates chemokine (C-X-C motif) receptor (CXCR)4. This prompted us to further examine this unexpected pharmacological behavior.
Xianlong Gao +5 more
doaj +1 more source
Investigating the role of Atypical Chemokine Receptor 3 in cancer development [PDF]
, 2020 Atypical Chemokine Receptor 3 (ACKR3) is a seven-transmembrane spanning receptor with pleiotropic functions in development, homeostasis and pathophysiology.
Karatza, Angeliki
core
Advanced Science, Volume 13, Issue 7, 3 February 2026.In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo +19 more
wiley +1 more source
Atypical Chemokine Receptor 3 Generates Guidance Cues for CXCL12-Mediated Endothelial Cell Migration
Frontiers in Immunology, 2019 Chemokine receptor CXCR4, its ligand stromal cell-derived factor-1 (CXCL12) and the decoy receptor atypical chemokine receptor 3 (ACKR3, also named CXCR7), are involved in the guidance of migrating cells in different anatomical districts.
Chiara Tobia +8 more
doaj +1 more source
Molecular Medicine, 2022 Background Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain less studied. Methods Single-cell RNA
Yu-bin He +12 more
doaj +1 more source
Advanced Science, Volume 13, Issue 12, 27 February 2026.Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You +12 more
wiley +1 more source