Results 71 to 80 of about 3,455 (202)
Molecular Pharmacology, 2023 Atypical chemokine receptor 3 (ACKR3), formerly referred to as CXCR7, is considered to be an interesting drug target. In this study, we report on the synthesis, pharmacological characterization and radiolabeling of VUF15485, a new ACKR3 small-molecule ...
Aurelien M. Zarca +24 more
semanticscholar +1 more source
CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes [PDF]
, 2020 © 2020 The Authors G protein-coupled receptors are a major class of membrane receptors that mediate physiological and pathophysiological cellular signaling.
Caspar, Birgit +4 more
core +3 more sources
bioRxiv, 2023 The canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell migration.
Christopher T. Schafer +4 more
semanticscholar +1 more source
Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]
, 2018 The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Amadori, Alberto +3 more
core +1 more source
Journal of Neuroinflammation, 2018 Background Atypical chemokine receptor 3 (ACKR3, synonym CXCR7) is increasingly considered relevant in neuroinflammatory conditions, in which its upregulation contributes to compromised endothelial barrier function and may ultimately allow inflammatory ...
Christine Silwedel +6 more
doaj +1 more source
RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation [PDF]
, 2017 Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Daniels, Brian P. +9 more
core +1 more source
β‐arrestin‐biased ACKR3 Promotes Gαi:β‐arrestin Complex Formation
The FASEB Journal, 2021 Atypical chemokine receptor 3 (ACKR3)—previously known as CXC‐chemokine receptor 7 (CXCR7)—is involved in a wide range of physiological processes including angiogenesis, neuronal development, and tumorigenesis. As a β‐arrestin biased G protein‐coupled receptor (GPCR), ACKR3 recruits β‐arrestin, but lacks G protein activity.
Taylor Kohlmann +2 more
openaire +1 more source
Predicting Autism Spectrum Disorder Using Blood-based Gene Expression Signatures and Machine Learning [PDF]
, 2017 Objective: The aim of this study was to identify a transcriptomic signature that could be used to classify subjects with autism spectrum disorder (ASD) compared to controls on the basis of blood gene expression profiles.
���������
core +1 more source
Plasticity of seven-transmembrane-helix receptor heteromers in human vascular smooth muscle cells.
PLoS ONE, 2021 Recently, we reported that the chemokine (C-X-C motif) receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) heteromerize with α1A/B/D-adrenoceptors (ARs) and arginine vasopressin receptor 1A (AVPR1A) in recombinant systems and in rodent and human
Lauren J Albee +2 more
doaj +1 more source
EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential
, 2020 Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Here, we investigate how transcriptional changes in bone marrow (BM) MSCs result in long-lasting effects
Cauchy, P. +6 more
core +1 more source