Results 81 to 90 of about 3,455 (202)

Identification and analysis of mutational hotspots in oncogenes and tumour suppressors [PDF]

, 2017
Background: The key to interpreting the contribution of a disease-associated mutation in the development and progression of cancer is an understanding of the consequences of that mutation both on the function of the affected protein and on the pathways ...
Baeissa, Hanadi, Benstead-Hume, Graeme, Pearl, Frances M G, Richardson, Christopher J   +3 more
core   +1 more source

Inflammatory niches as spatial drivers of disease mechanisms and targets for personalized treatment

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This study provides a comprehensive review of how spatial transcriptomics reveals disease‐specific inflammatory niches across multiple skin disorders, highlighting key immune–stromal, neuro–immune and metabolic interactions that were previously unappreciated in non‐spatial analyses. Abstract Disease states are increasingly recognized as being shaped by
Rundong Jiang, Zhiqin Fang, Lam C. Tsoi, Johann E. Gudjonsson   +3 more
wiley   +1 more source

Disruption of maternal ACKR3 has profound effects on embryos and offspring

bioRxiv, 2023
ACKR3, scavenges and degrades the stem cell recruiting chemokine CXCL12 which is essential for proper embryonic, and in particular hematopoietic, development. Here we demonstrate strong expression of ACKR3 on trophoblasts. Using a pharmacological blocker
A. Fukuoka, G. Wilson, Elise Pitmon, Lily Koumbas Foley, H. Johnsson, M. Pingen, G. Graham   +6 more
semanticscholar   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Investigating the role of Atypical Chemokine Receptor 3 in cancer development [PDF]

, 2020
Atypical Chemokine Receptor 3 (ACKR3) is a seven-transmembrane spanning receptor with pleiotropic functions in development, homeostasis and pathophysiology.
Karatza, Angeliki
core  

ACKR3 in Skin Homeostasis, an Overlooked Player in the CXCR4/CXCL12 Axis.

Journal of Investigative Dermatology
CXCL12 and its receptor CXCR4 emerge as critical regulators within the intricate network of processes ensuring skin homeostasis. In this review, we discuss their spatial distribution and function in steady-state skin; delve into their role in acute wound healing, with emphasis on fibrotic and regenerative responses; and explore their relevance in skin ...
Gabriela Cuesta-Margolles, Géraldine Schlecht-Louf, Françoise Bachelerie   +2 more
semanticscholar   +3 more sources

RAMP3 determines rapid recycling of atypical chemokine receptor-3 for guided angiogenesis. [PDF]

, 2019
Receptor-activity-modifying proteins (RAMPs) are single transmembrane-spanning proteins which serve as molecular chaperones and allosteric modulators of G-protein-coupled receptors (GPCRs) and their signaling pathways. Although RAMPs have been previously
Caron, Kathleen M, Davis, Reema B, Dy, Danica, Harris, Matthew, Ladds, Graham, Mackie, Duncan I, Nielsen, Natalie R, Singh, Smriti   +7 more
core   +2 more sources

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

Characterization of a chimeric chemokine as a specific ligand for ACKR3 [PDF]

Journal of Leukocyte Biology, 2018
Abstract Chemokines, small chemotactic cytokines, orchestrate cell migration by binding to their cognate chemokine receptors. While chemokine-mediated stimulation of typical G-protein-coupled chemokine receptors leads to cell migration, binding of chemokines to atypical chemokine receptors (ACKRs) does not induce canonical signaling ...
Ameti, R, Melgrati, S, Radice, E, Cameroni, E, Hub, E, Thelen, S, Rot, A, Thelen, M   +7 more
openaire   +4 more sources

New pairings and deorphanization among the atypical chemokine receptor family — physiological and clinical relevance

Frontiers in Immunology, 2023
Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands.
Martyna Szpakowska, Giulia D’Uonnolo, Giulia D’Uonnolo, Rafael Luís, Rafael Luís, Rafael Luís, Ana Alonso Bartolomé, Ana Alonso Bartolomé, Marcus Thelen, Daniel F. Legler, Andy Chevigné   +10 more
doaj   +1 more source