Development of Acridone Derivatives: Targeting c-MYC Transcription in Triple-Negative Breast Cancer with Inhibitory Potential [PDF]
Antioxidants, 2023 Breast cancer, especially the aggressive triple-negative subtype, poses a serious health threat to women. Unfortunately, effective targets are lacking, leading to a grim prognosis. Research highlights the crucial role of c-MYC overexpression in this form
Jing-Wei Liang +5 more
doaj +2 more sources
Acridone Derivatives for Near-UV Radical Polymerization: One-Component Type II vs. Multicomponent Behaviors [PDF]
MoleculesIn this work, two novel acridone-based photoinitiators were designed and synthesized for the free radical polymerization of acrylates with a light-emitting diode emitting at 405 nm.
Adel Noon +9 more
doaj +2 more sources
Synthetic Modifications of a Pb2+-Sensor Acridono-Crown Ether for Covalent Attachment and Their Effects on Selectivity [PDF]
MoleculesBecause of environmental impact, there is a great need for chemosensors, especially for toxic heavy metals such as lead. The conventional instrumental analytical techniques rarely provide an available real-time sensing platform, thus the development of ...
Panna Vezse +4 more
doaj +2 more sources
Synthesis and Biological Evaluation of Acridone Derivatives for Antimicrobial and Antifungal Applications [PDF]
Journal of Experimental PharmacologyAli Salman Al-Shami,1,2 Jalal Alkadsi3 1Department of Pharmacology, Faculty of Medicine, Sanaa University, Sanaa City, Republic of Yemen; 2Jiblah University for Medical and Health Science, Ibb City, Republic of Yemen; 3Department of Medicinal Chemistry ...
Al-Shami AS, Alkadsi J
doaj +2 more sources
Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Pan-histone deacetylase (HDAC) inhibitors often have some toxic side effects. In this study, three series of novel polysubstituted N-alkyl acridone analogous were designed and synthesised as HDAC isoform-selective inhibitors.
Ze Wang +9 more
doaj +2 more sources
Structural and mechanistic insights into Quinolone Synthase to address its functional promiscuity [PDF]
Communications BiologyQuinolone synthase from Aegle marmelos (AmQNS) is a type III polyketide synthase that yields therapeutically effective quinolone and acridone compounds. Addressing the structural and molecular underpinnings of AmQNS and its substrate interaction in terms
Mallika Vijayanathan +7 more
doaj +2 more sources
Wet Photolithography From Hydrogen Abstraction of a Quasi‐Orthogonal Aggregation‐Induced Emitter [PDF]
Advanced ScienceA new aggregation‐induced emission (AIE) luminogen is obtained by dimerizing acridin‐9(10H)‐one (Ac), an aggregation‐caused quenching (ACQ) effect monomer via an N─N bond and forming 9H,9′H‐[10,10′‐biacridine]‐9,9′‐dione (DiAc) with D2d symmetry.
Chen Cao +9 more
doaj +2 more sources
Molecules, 2021 A synthetic route to new heterocyclic 1,1-donor–acceptor-substituted alkenes starting with N-methyl-acridone, xanthone, and thioxanthone was investigated, leading to the acridone- and xanthone-derived products methyl 2-methoxy-2-(10-methylacridin-9 (10H)-
Tim Lippold +2 more
doaj +1 more source
Frontiers in Oncology, 2021 Drug resistance is one of the critical challenges faced in the treatment of Glioma. There are only limited drugs available in the treatment of Glioma and among them Temozolomide (TMZ) has shown some effectiveness in treating Glioma patients, however, the
Malobika Chakravarty +8 more
doaj +1 more source
Synthesis and Application in Cell Imaging of Acridone Derivatives
Applied Sciences, 2020 Tricyclic acridone derivatives have been extensively developed as antimicrobial, antimalarial, and antitumor drugs due to their broad spectrum of drug design and biological activity.
Yung-Chieh Chan +5 more
doaj +1 more source