Results 31 to 40 of about 1,631 (150)

ALCALOIDES ACRIDÔNICOS INIBEM CATEPSINA L E V

Química Nova, 2016
Cathepsins represent a class of enzymes that has the primary function of randomly degrading proteins in the lysosomes, although are also involved in different pathologies.
Emerson F. Marques, Paulo C. Vieira, Richele P. Severino   +2 more
doaj   +1 more source

A New Coumarin-Acridone Compound as a Fluorescence Probe for Fe³⁺ and Its Application in Living Cells and Zebrafish

Molecules, 2021
A new coumarin-acridone fluorescent probe S was designed and synthesized, and the structure was confirmed with 1H/13C NMR spectrometry, single-crystal X-ray diffraction, and high-resolution mass spectrometry.
Jiayong Huang, Zhenshuo Yan, Peiling Qiu, Yufeng Mo, Qizhen Cao, Qiuhong Li, Lini Huo, Lichun Zhao   +7 more
doaj   +1 more source

Acridone alkaloids. X. 13C-Nuclear magnetic resonance spectra of acridone alkaloids.

Chemical and Pharmaceutical Bulletin, 1983
The 13C-nuclear magnetic resonance spectra of twenty-seven acridone alkaloids including angular pyrano [2, 3-c] acridones and linear pyrano [3, 2-b] acridones have been analyzed and assigned. The information should be useful for the structure elucidation of new acridone alkaloids.
HIROSHI FURUKAWA, MOTOI YOGO, TIANSHUNG WU   +2 more
openaire   +2 more sources

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

1-Hydroxy-3,4-dimethoxy-10-methylacridin-9-one

IUCrData, 2020
There are two independent molecules in the asymmetric unit of the title compound, C16H15NO4, which was isolated from fruits of Zanthoxylum leprieurii. The atoms of the three rings of each molecule are close to coplanar with the largest deviations from ...
Rodrigo S. A. de Araújo, Ernestine N. T. Zondegoumba, Whisthler L. D. Tankoua, Barthelemy Nyassé, Francisco J. B. Mendonça-Junior, Carlos A. De Simone   +5 more
doaj   +1 more source

Novel acridone derivatives probed using DFT, including design, synthesis, characterization with anti-oxidant and anti-mitotic screening

Results in Chemistry, 2023
Applying the Ullmann synthesis, substituted aniline and o-halobenzoic acids are combined with potassium carbonate and copper powder to produce N- (substituted phenyl) anthranilic acids.
S. Sulthanudeen, Predhanekar Mohamed Imran, M. Selvakumaran, Attar Kubaib   +3 more
doaj   +1 more source

Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi

Angewandte Chemie, Volume 137, Issue 44, October 27, 2025.
Type III polyketide synthases (T3PKSs) produce diverse compounds of ecological and clinical importance. Here, the activity of 37 fungal T3PKSs was profiled, revealing unexpected products and generating several pharmaceutical precursors. The machine learning model trained on the activity data accurately extrapolates the predictions to other enzymes and ...
Nika Sokolova, Stepan S. Denisov, Thomas Hackl, Kristina Haslinger   +3 more
wiley   +2 more sources

Anion‐π+ Type AIE‐Active Photosensitizers for Ferroptosis‐Driven Photodynamic Immunotherapy Against Hypoxic Solid Tumors

Aggregate, Volume 7, Issue 1, January 2026.
An anion‐π+ type AIE photosensitizer (TMTPA NPs) with NIR emission was successfully developed through a sulfidation strategy. With its exceptional mitochondrial targeting abilities and efficient Type I ROS generation, TMTPA NPs effectively trigger ferroptosis.
Lingxiu Liu, Jianye Gong, Xue Wang, Ying Zhang, Guoyu Jiang, Jianguo Wang, Ben Zhong Tang   +6 more
wiley   +1 more source

Ultrasound-Assisted Wittig Reaction for the Synthesis of 3-Substituted 4-Chloroquinolines and Quinolin-4(1H)-ones with Extended π-Conjugated Systems

Journal of Chemistry, 2022
3-(Vinyl-/buta-1,3-dien-1-yl/4-phenylbuta-1,3-dien-1-yl)-4-chloro quinolines and quinolin-4(1H)-ones were synthesized by ultrasound-assisted Wittig reaction of the corresponding 4-chloro-3-formylquinoline and 3-formylquinolin-4(1H)-ones with ...
Wahiba Frites, Massaab Khalfaoui, Lamouri Hammal, Vera L. M. Silva, Artur M. S. Silva   +4 more
doaj   +1 more source

Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N′-dialkyl-9,9′-biacridylidenes

Biomolecules, 2019
The anticancer activity of acridone derivatives has attracted increasing interest, therefore, a variety of substituted analogs belonging to this family have been developed and evaluated for their anti-cancer properties.
Marios G. Krokidis, Zara Molphy, Eleni K. Efthimiadou, Marianna Kokoli, Smaragda-Maria Argyri, Irini Dousi, Annalisa Masi, Kyriakos Papadopoulos, Andrew Kellett, Chryssostomos Chatgilialoglu   +9 more
doaj   +1 more source