Results 41 to 50 of about 1,631 (150)

A Unique Topoisomerase II Inhibitor with Dose-Affected Anticancer Mechanisms and Less Cardiotoxicity

Cells, 2021
Type II DNA topoisomerase (topo II) is an essential nuclear enzyme and a well-validated anticancer drug target. Previously, we have carried out several rounds of structural optimizations on our in-house topo II inhibitor E17, which was shown to have ...
Zhi-Ying Li, Guang-Sen Xu, Xun Li
doaj   +1 more source

Fluorescent Dyes for Probing Intracellular and Subcellular Polarity

Chemistry–Methods, Volume 6, Issue 1, January 2026.
Fluorescent probes are crucial tools for measuring cellular microenvironment polarity, a parameter that influences physiological organelle function and diseases such as cancer. This text details the probes' physicochemical principles, intracellular targeting strategies, and key photophysical parameters for polarity estimation.
M. Carmen Gonzalez‐Garcia, Maria J. Ruedas‐Rama, Juan A. González‐Vera, Emilio Garcia‐Fernandez, Angel Orte   +4 more
wiley   +1 more source

Divergent Synthesis and Crystal Engineering of Room‐Temperature Phosphorescent Carbonyl‐Bridged Triphenylamines

Angewandte Chemie, Volume 137, Issue 38, September 15, 2025.
Solid state packing of triphenylamine derivatives is modulated by the variation of aryl bridges, endowing a wide diversity of luminescence properties. Closely packed, parallel structures induce room temperature phosphorescence (RTP) dominated spectra with long RTP lifetimes (τPh), while nonparallel, more spaced motifs result in competitive fluorescence
Cory Ruchlin, Durbis J. Castillo‐Pazos, Juan D. Lasso, Ehsan Hamzehpoor, Aleksandar Mikov, Chao‐Jun Li, Dmytro F. Perepichka   +6 more
wiley   +2 more sources

Coupled Excited-State Dynamics in N-Substituted 2-Methoxy-9-Acridones

Frontiers in Chemistry, 2019
Fluorophores of the acridone family have been widely employed in many applications, such as DNA sequencing, the detection of biomolecules, and the monitoring of enzymatic systems, as well as being the bases of intracellular sensors and even antitumoral ...
M. Carmen Gonzalez-Garcia, Pilar Herrero-Foncubierta, Pilar Herrero-Foncubierta, Silvia Castro, Sandra Resa, Jose M. Alvarez-Pez, Delia Miguel, Juan M. Cuerva, Emilio Garcia-Fernandez, Angel Orte   +9 more
doaj   +1 more source

Excited State Modulation in Carbene‐Metal‐Amides to Design Fast and Bright Blue Delayed Fluorescence

Advanced Functional Materials, Volume 35, Issue 52, December 23, 2025.
Gold‐centered carbene‐metal amide (CMA) materials with carbonyl‐group substitution on the amide donor ligand. Molecular design ensures that the charge transfer (CT) state is lower in energy than the locally excited (3LE) states. The energy difference between CT and LE states controls the rate of the delayed fluorescence.
Charlotte Riley, Nguyen Le Phuoc, Mikko Linnolahti, Alexander S. Romanov   +3 more
wiley   +1 more source

Application of Lanthanide Shift Reagent to the ¹H-NMR Assignments of Acridone Alkaloids

Molecules, 2020
This study investigates the application of the paramagnetic shift reagent tris(dipivaloylmethanato)-europium(III) in NMR spectral studies of permethoxyacridone alkaloids (1–3) and pyranoacridone alkaloids (4–6).
Sio-Hong Lam, Hsin-Yi Hung, Ping-Chung Kuo, Daih-Huang Kuo, Fu-An Chen, Tian-Shung Wu   +5 more
doaj   +1 more source

Multi‐channel charge transfer delayed fluorescence enabling high‐efficiency organic light‐emitting diodes

FlexMat, Volume 2, Issue 4, Page 533-581, December 2025.
The enhanced utilization of triplet excitons is a central theme in the evolution of organic luminescent materials. This review sums up recent research on multi‐channel charge transfer delayed fluorescence molecules, which exhibit a unique distribution of excited‐state energy levels, thereby enhancing the utilization rate of triplet excitons and ...
Guo‐Wei Chen, Zhen Zhang, Xin‐Yi Zeng, Yi‐Hui He, Guo Yuan, Yan‐Qing Li, Jian‐Xin Tang   +6 more
wiley   +1 more source

Redetermination and absolute configuration of atalaphylline

Acta Crystallographica Section E, 2010
The title acridone alkaloid [systematic name: 1,3,5-trihydroxy-2,4-bis(3-methylbut-2-enyl)acridin-9(10H)-one], C23H25NO4, has previously been reported as crystallizing in the chiral orthorhombic space group P212121 [Chantrapromma et al. (2010).
Hoong-Kun Fun, Chin Sing Yeap, Suchada Chantrapromma   +2 more
doaj   +1 more source

Degrees of Sulfonation: Mapping the Reactivity Landscape of Acridine and Acridone

Organics
Although sulfonated acridines and acridones are valuable scaffolds in diagnostics and materials science, to our best knowledge, there is no comprehensive study that addresses how the degree of sulfonation depends on reaction parameters. To fill this gap,
Péter Kisfaludi, Sára Spátay, Péter Huszthy, Ádám Golcs   +3 more
doaj   +1 more source

Visible Light‐Promoted Aerobic Oxidation of Boronic Acids and Esters Utilizing a Benzothioxanthene Imide as the Photocatalyst

European Journal of Organic Chemistry, Volume 28, Issue 44, November 28, 2025.
A photochemical aerobic oxidation protocol using a benzothioxanthene imide as the photocatalyst at a low catalyst loading (0.01 mol%) is developed for the oxidation of boronic acids and esters. Herein, a sustainable and eco‐friendly protocol is reported for the aerobic photochemical oxidation of boronic acids or esters, utilizing a dibenzothioxanthene ...
Stamatis K. Serviou, Petros L. Gkizis, Darío Puchán Sánchez, Soussana Azar, Arthur H. G. David, Clement Cabanetos, Christoforos G. Kokotos   +6 more
wiley   +1 more source