Multi-Target Actions of Acridones from Atalantia monophylla towards Alzheimer’s Pathogenesis and Their Pharmacokinetic Properties [PDF]
Pharmaceuticals, 2021 Ten acridones isolated from Atalantia monophylla were evaluated for effects on Alzheimer’s disease pathogenesis including antioxidant effects, acetylcholinesterase (AChE) inhibition, prevention of beta-amyloid (Aβ) aggregation and neuroprotection.
Pitchayakarn Takomthong +8 more
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Synthesis of Xanthones, Thioxanthones and Acridones by a Metal-Free Photocatalytic Oxidation Using Visible Light and Molecular Oxygen [PDF]
Molecules, 2021 9H-Xanthenes, 9H-thioxanthenes and 9,10-dihydroacridines can be easily oxidized to the corresponding xanthones, thioxanthones and acridones, respectively, by a simple photo-oxidation procedure carried out using molecular oxygen as oxidant under the ...
Alejandro Torregrosa-Chinillach +1 more
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Application of Lanthanide Shift Reagent to the 1H-NMR Assignments of Acridone Alkaloids [PDF]
Molecules, 2020 This study investigates the application of the paramagnetic shift reagent tris(dipivaloylmethanato)-europium(III) in NMR spectral studies of permethoxyacridone alkaloids (1–3) and pyranoacridone alkaloids (4–6).
Sio-Hong Lam +5 more
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Multi spectroscopic and molecular simulation studies of propyl acridone binding to calf thymus DNA in the presence of electromagnetic force [PDF]
BioImpacts, 2023 Introduction: Here, the interaction behavior between propyl acridones (PA) and calf thymus DNA (ct-DNA) has been investigated to attain the features of the binding behavior of PA with ct-DNA, which includes specific binding sites, modes, and constants ...
Atena Sharifi-Rad +9 more
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Building Accurate Intracellular Polarity Maps through Multiparametric Microscopy [PDF]
Methods and Protocols, 2020 The precise knowledge of intracellular polarity, a physiological parameter that involves complex and intertwined intracellular mechanisms, may be relevant in the study of important diseases like cancer or Alzheimer’s.
M. Carmen Gonzalez-Garcia +3 more
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An Overview of the Medicinally Important Plant Type III PKS Derived Polyketides [PDF]
Frontiers in Plant Science, 2021 Plants produce interesting secondary metabolites that are a valuable source of both medicines for human use, along with significant advantages for the manufacturer species.
Renu Bisht +3 more
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Acridones as promising drug candidates against Oropouche virus [PDF]
Current Research in Microbial SciencesOropouche virus (OROV) is an emerging vector-borne arbovirus found in South America that causes Oropouche fever, a febrile infection similar to dengue fever.
Marielena Vogel Saivish +16 more
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Integrated Analytical Tools for Accessing Acridones and Unrelated Phenylacrylamides from Swinglea glutinosa [PDF]
Molecules, 2019 In natural product studies, the purification of metabolites is an important challenge. To accelerate this step, alternatives such as integrated analytical tools should be employed.
Ana Calheiros de Carvalho +5 more
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‘Acridines’ as New Horizons in Antifungal Treatment [PDF]
Molecules, 2020 Frequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide.
Iwona Gabriel
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Synthesis of acridone derivatives via heterologous expression of a plant type III polyketide synthase in Escherichia coli [PDF]
Microbial Cell Factories, 2020 Background Acridone alkaloids are heterocyclic compounds that exhibit a broad-range of pharmaceutical and chemotherapeutic activities, including anticancer, antiviral, anti-inflammatory, antimalarial, and antimicrobial effects. Certain plant species such
Gyu-Sik Choi +3 more
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