Results 11 to 20 of about 2,769 (197)

Coupled Excited-State Dynamics in N-Substituted 2-Methoxy-9-Acridones [PDF]

Frontiers in Chemistry, 2019
Fluorophores of the acridone family have been widely employed in many applications, such as DNA sequencing, the detection of biomolecules, and the monitoring of enzymatic systems, as well as being the bases of intracellular sensors and even antitumoral ...
M. Carmen Gonzalez-Garcia, Pilar Herrero-Foncubierta, Pilar Herrero-Foncubierta, Silvia Castro, Sandra Resa, Jose M. Alvarez-Pez, Delia Miguel, Juan M. Cuerva, Emilio Garcia-Fernandez, Angel Orte   +9 more
doaj   +8 more sources

Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N′-dialkyl-9,9′-biacridylidenes [PDF]

Biomolecules, 2019
The anticancer activity of acridone derivatives has attracted increasing interest, therefore, a variety of substituted analogs belonging to this family have been developed and evaluated for their anti-cancer properties.
Marios G. Krokidis, Zara Molphy, Eleni K. Efthimiadou, Marianna Kokoli, Smaragda-Maria Argyri, Irini Dousi, Annalisa Masi, Kyriakos Papadopoulos, Andrew Kellett, Chryssostomos Chatgilialoglu   +9 more
doaj   +3 more sources

Electron-Poor Acridones and Acridiniums as Super Photooxidants in Molecular Photoelectrochemistry by Unusual Mechanisms [PDF]

Angewandte Chemie, 2023
Electron-deficient acridones and in situ generated acridinium salts are reported potent, closed-shell photooxidants that undergo surprising mechanisms.
Barham, Joshua Philip, Boháčová, Soňa, Butera, Valeria, Domański, Michał, Schmid, Simon, Slanina, Tomáš, Wu, Shangze, Žurauskas, Jonas   +7 more
core   +8 more sources

Boron Trifluoride Etherate Promoted Microwave-Assisted Synthesis of Antimalarial Acridones. [PDF]

RSC Adv, 2019
A microwave-assisted, rapid and efficient method using boron trifluoride etherate (BF3.Et2O) for the synthesis of acridones, via an intramolecular acylation of N-phenylanthranilic acid derivatives, has been developed.
Kancharla P, Dodean RA, Li Y, Kelly JX.
europepmc   +4 more sources

Visible light-promoted metal-free aerobic photooxidation of xanthenes, thioxanthenes and dihydroacridines in deep eutectic solvents [PDF]

Tetrahedron Green Chem, 2023
Benzylic systems such as 9H-xanthenes, 9H-thioxanthenes and 9,10-dihydroacridines can be easily oxidized to the corresponding xanthones, thioxanthones or acridones, respectively, in deep eutectic solvents by a visible blue light-promoted photooxidation ...
Sarah-Jayne Burlingham, Alejandro Torregrosa-Chinillach, Diego A. Alonso, Rafael Chinchilla   +3 more
doaj   +3 more sources

Synthesis and Biological Evaluation of Acridone Derivatives for Antimicrobial and Antifungal Applications [PDF]

Journal of Experimental Pharmacology
Ali Salman Al-Shami,1,2 Jalal Alkadsi3 1Department of Pharmacology, Faculty of Medicine, Sanaa University, Sanaa City, Republic of Yemen; 2Jiblah University for Medical and Health Science, Ibb City, Republic of Yemen; 3Department of Medicinal Chemistry ...
Al-Shami AS, Alkadsi J
doaj   +2 more sources

Synthesis, Structural Modification, and Bioactivity Evaluation of Substituted Acridones as Potent Microtubule Affinity-Regulating Kinase 4 Inhibitors. [PDF]

ACS Pharmacol Transl Sci, 2023
Acridones present numerous pharmacological activities, including inhibition of microtubule affinity-regulating kinase 4 (MARK4) kinase activity. To investigate structure-activity relationships and develop potent MARK4 inhibitors, derivatives of 2 ...
Voura M, Anwar S, Sigala I, Parasidou E, Fragoulidou S, Hassan MI, Sarli V.   +6 more
europepmc   +2 more sources

Acridones Are Highly Potent Inhibitors of Toxoplasma gondii Tachyzoites. [PDF]

ACS Infect Dis, 2021
Acridone derivatives, which have been shown to have in vitro and in vivo activity against Plasmodium spp, inhibit Toxoplasma gondii proliferation at picomolar concentrations. Using enzymatic assays, we show that acridones inhibit both T.
Alday PH, McConnell EV, Boitz Zarella JM, Dodean RA, Kancharla P, Kelly JX, Doggett JS.   +6 more
europepmc   +2 more sources

Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials. [PDF]

J Med Chem, 2020
The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for ...
Kancharla P, Dodean RA, Li Y, Pou S, Pybus B, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, Sousa J, Marcsisin S, Caridha D, Xie L, Vuong C, Zeng Q, Zhang J, Zhang P, Lin H, Butler K, Roncal N, Gaynor-Ohnstad L, Leed SE, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Mu J, Bayles BR, Cooper RA, Reynolds KA, Smilkstein MJ, Riscoe MK, Kelly JX.   +41 more
europepmc   +2 more sources

Development of Next-Generation Antimalarial Acridones with Radical Cure Potential. [PDF]

J Med Chem
Building from our previous lead compound T111 (1) possessing activity against both Plasmodium falciparum asexual blood-stage (ABS) and Plasmodium berghei liver-stage (LS) parasites, next-generation antimalarial acridones were systematically designed and ...
Dodean RA, Li Y, Zhang X, Caridha D, Madejczyk MS, Jin X, Dennis WE, Chetree R, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca J, Vuong C, Pannone K, Dinh HT, Mdaki K, Leed S, Martin ML, Pybus BS, Pou S, Winter RW, Liebman KM, Williams R, Kumar A, Chim-Ong A, Cui L, Orena S, Assimwe J, Tibagambirwa I, Byaruhanga O, Angutoko P, Legac J, Kreutzfeld O, Rosenthal PJ, Cooper RA, Nilsen A, Riscoe MK, Roth A, Kancharla P, Kelly JX.   +40 more
europepmc   +2 more sources