Results 21 to 30 of about 2,769 (197)

New Acridone- and (Thio)Xanthone-Derived 1,1-Donor–Acceptor-Substituted Alkenes: pH-Dependent Fluorescence and Unusual Photooxygenation Properties

Molecules, 2021
A synthetic route to new heterocyclic 1,1-donor–acceptor-substituted alkenes starting with N-methyl-acridone, xanthone, and thioxanthone was investigated, leading to the acridone- and xanthone-derived products methyl 2-methoxy-2-(10-methylacridin-9 (10H)-
Tim Lippold, Jörg M. Neudörfl, Axel Griesbeck   +2 more
doaj   +1 more source

Tuning the Excited State Character of Amine/Carbonyl Thermally Activated Delayed Fluorescence Emitters with Ring Fusion. [PDF]

Chemistry
Ring fusion in MR‐TADF emitters can affect the charge transfer excited state and therefore the photophysical properties. Here we investigate the effect of ring fusion in two structurally similar molecules to identify the advantages and disadvantages of this strategy.
Kalab T, Gogoulis AT, Patrick BO, Hudson ZM.   +3 more
europepmc   +2 more sources

Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials. [PDF]

J Med Chem, 2019
Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support the renewed eradication agenda.
Dodean RA, Kancharla P, Li Y, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, Sousa J, Marcsisin S, Caridha D, Xie L, Vuong C, Zeng Q, Zhang J, Zhang P, Lin H, Butler K, Roncal N, Gaynor-Ohnstad L, Leed SE, Nolan C, Huezo SJ, Rasmussen SA, Stephens MT, Tan JC, Cooper RA, Smilkstein MJ, Pou S, Winter RW, Riscoe MK, Kelly JX.   +38 more
europepmc   +2 more sources

Drug Discovery Based on Oxygen and Nitrogen (Non-)Heterocyclic Compounds Developed @LAQV–REQUIMTE/Aveiro

Pharmaceuticals, 2023
Artur Silva’s research group has a long history in the field of medicinal chemistry. The development of new synthetic methods for oxygen (mostly polyphenols, e.g., 2- and 3-styrylchromones, xanthones, flavones) and nitrogen (e.g., pyrazoles, triazoles ...
Joana L. C. Sousa, Hélio M. T. Albuquerque, Artur M. S. Silva   +2 more
doaj   +1 more source

Engineered biosynthesis of plant polyketides by type III polyketide synthases in microorganisms

Frontiers in Bioengineering and Biotechnology, 2022
Plant specialized metabolites occupy unique therapeutic niches in human medicine. A large family of plant specialized metabolites, namely plant polyketides, exhibit diverse and remarkable pharmaceutical properties and thereby great biomanufacturing ...
Chang Liu, Sijin Li
doaj   +1 more source

Novel acridone derivatives probed using DFT, including design, synthesis, characterization with anti-oxidant and anti-mitotic screening

Results in Chemistry, 2023
Applying the Ullmann synthesis, substituted aniline and o-halobenzoic acids are combined with potassium carbonate and copper powder to produce N- (substituted phenyl) anthranilic acids.
S. Sulthanudeen, Predhanekar Mohamed Imran, M. Selvakumaran, Attar Kubaib   +3 more
doaj   +1 more source

Aromatic Iodides: Synthesis and Conversion to Heterocycles

Chemistry Proceedings, 2022
Aromatic heterocycles can be found in many molecules endowed with specific properties, in particular for applications in the fields of medicinal chemistry and materials science.
Florence Mongin, William Erb, Frédéric Lassagne   +2 more
doaj   +1 more source

Probing the Inhibition of Microtubule Affinity Regulating Kinase 4 by N-Substituted Acridones. [PDF]

Sci Rep, 2019
Microtubule affinity regulating kinase 4 (MARK4) becomes a unique anti-cancer drug target as its overexpression is responsible for different types of cancers.
Voura M, Khan P, Thysiadis S, Katsamakas S, Queen A, Hasan GM, Ali S, Sarli V, Hassan MI.   +8 more
europepmc   +2 more sources

Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis [PDF]

, 2007
Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and thamnosmonin, seven acridones, namely, acrimarine B, 2 ...
A. Chaboud, C. Bayet, C. Dumontet, C. Fazio, D. Guilet, I. Raad, N. Darbour, O. Berger   +7 more
core   +3 more sources

A facile synthesis of N-H-and N-substituted acridine-1,8-diones under sonic condition [PDF]

, 2013
Synthesis of an assembly of structurally important N-H- and N-substituted acridine-1,8-diones by CAN (ceric ammonium nitrate) catalysed one-pot four-component reaction of electron-deficient and electron-rich aromatic aldehydes and aromatic amines or ...
Pasha, M.A., Sudha, S.
core   +3 more sources