Results 71 to 80 of about 1,498,374 (404)

Angiogenesis as a Survival Mechanism in Heartworm Disease: The Role of Fructose-Bisphosphate Aldolase and Actin from Dirofilaria immitis in an In Vitro Endothelial Model

Animals
Heartworm disease, caused by Dirofilaria immitis, is a vector-borne zoonotic disease, (mainly affecting canids and felids) causing chronic vascular and pulmonary pathology in its early stages, which worsens with parasite load and/or death of adult worms ...
Manuel Collado-Cuadrado, Claudia Alarcón-Torrecillas, Alfonso Balmori-de la Puente, Iván Rodríguez-Escolar, Elena Infante González-Mohino, Miguel Pericacho, Rodrigo Morchón   +6 more
doaj   +1 more source

Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis [PDF]

, 2007
During animal cell chemotaxis, signalling at the plasma membrane induces actin polymerisation to drive forward cell movement. Since the cellular pool of actin is limited, efficient protrusion formation also requires the coordinated disassembly of pre ...
Baum, B, Jovceva, E, Larsen, MR, Timms, JF, Waterfield, MD   +4 more
core  

Soft Listeria: actin-based propulsion of liquid drops [PDF]

, 2003
We study the motion of oil drops propelled by actin polymerization in cell extracts. Drops deform and acquire a pear-like shape under the action of the elastic stresses exerted by the actin comet.
A. Mogilner, A. Mogilner, A.E.Carlsson, Cécile Sykes, D. Yarar, F. Gerbal, H. A. Kramers, H. Eyring, Hakim Boukellal, J. Fradelizi, J. Prost, Jacques Prost, Jean-François Joanny, Otger Campás, V. Noireaux   +14 more
core   +2 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

eLife
Cell migration is a key process in the shaping and formation of tissues. During sprouting angiogenesis, endothelial tip cells invade avascular tissues by generating actomyosin-dependent forces that drive cell migration and vascular expansion ...
Igor Kondrychyn, Liqun He, Haymar Wint, Christer Betsholtz, Li-Kun Phng   +4 more
doaj   +1 more source

Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders

Frontiers in Endocrinology, 2023
β-arrestins, which have multiple cellular functions, were initially described as proteins that desensitize rhodopsin and other G protein-coupled receptors.
Tibor Szénási, Gábor Turu, Gábor Turu, László Hunyady, László Hunyady   +4 more
doaj   +1 more source

Mechanics of bundled semiflexible polymer networks [PDF]

, 2007
While actin bundles are used by living cells for structural fortification, the microscopic origin of the elasticity of bundled networks is not understood.
Bausch, A. R., Claessens, M. M. A. E., Frey, E., Heussinger, C., Lieleg, O.   +4 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Mechanics and regulation of cytokinetic abscission

Frontiers in Cell and Developmental Biology, 2022
Cytokinetic abscission leads to the physical cut of the intercellular bridge (ICB) connecting the daughter cells and concludes cell division. In different animal cells, it is well established that the ESCRT-III machinery is responsible for the ...
Virginia Andrade, Virginia Andrade, Arnaud Echard   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source