Results 21 to 30 of about 297,755 (331)

Dynamics of the Actin Cytoskeleton at Adhesion Complexes

Biology, 2021
The shape of cells is altered to allow cells to adapt to their changing environments, including responding to internally generated and externally applied force. Force is sensed by cell surface adhesion proteins that are enriched in sites where cells bind
Nicholas M. Cronin, Kris A. DeMali
doaj   +1 more source

A pharmacological cocktail for arresting actin dynamics in living cells. [PDF]

, 2011
The actin cytoskeleton is regulated by factors that influence polymer assembly, disassembly, and network rearrangement. Drugs that inhibit these events have been used to test the role of actin dynamics in a wide range of cellular processes.
Peng, Grace E, Weiner, Orion D, Wilson, Sarah R   +2 more
core   +2 more sources

Physical mechanism of the compressive response of F-actin networks: significance of crosslinker unbinding events

Theoretical and Applied Mechanics Letters, 2014
A model of crosslinker unbinding is implemented in a highly coarse-grained granular model of F-actin cytoskeleton. We employ this specific granular model to study the mechanisms of the compressive responses of F-actin networks.
Tong Li, Dean Hu, Prasad K.D.V. Yarlagadda, Yuantong Gu   +3 more
doaj   +1 more source

The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer [PDF]

, 2014
The contractile actin-myosin cytoskeleton provides much of the force required for numerous cellular activities such as motility, adhesion, cytokinesis and changes in morphology.
AP Somlyo, B Rafn, C Gaggioli, C Gally, CL Moncrieff, CS Loo, D Pyeon, DA Heerding, DM Pirone, DR Rhodes, ER Gomes, ET Kimchi, F Corpet, G Brunhofer, G Groeger, H Yamaguchi, HI Lowe, I Tan, I Tan, I Tan, I Tan, I Tan, J Schlingemann, J Schwarz, JM Elkins, JM Herbert, K Ando, K Lefort, KE Fisher, L Huo, L Luo, LJ Veer van’t, LR Pearce, LT Lam, M Jacobs, M Uehata, M Vicente-Manzanares, MA Fabian, MA Ginos, Mathieu Unbekandt, MF Olson, MF Olson, Michael F. Olson, N Nakamura, N Rath, P Basu, P Madaule, PL Podolin, R Cmejla, RW Scott, S Balasenthil, S Wang, S Wilkinson, S Yamamoto, SH Choi, SM Kim, T Heikkila, T Leung, T Sumi, X Liu, Y Hao, Y Ng, Y Zhao   +62 more
core   +1 more source

Spatial Organization of the Cytoskeleton enhances Cargo Delivery to Specific Target Areas on the Plasma Membrane of Spherical Cells [PDF]

, 2016
Intracellular transport is vital for the proper functioning and survival of a cell. Cargo (proteins, vesicles, organelles, etc.) is transferred from its place of creation to its target locations via molecular motor assisted transport along cytoskeletal ...
Hafner, Anne E., Rieger, Heiko
core   +2 more sources

Actin cytoskeleton: Putting a CAP on actin polymerization [PDF]

Current Biology, 2000
Two recent studies have identified a Drosophila homolog of cyclase-associated protein (CAP) as a developmentally important negative regulator of actin polymerization that may also directly mediate signal transduction.
Stevenson, Victoria A., Theurkauf, William E.   +1 more
openaire   +4 more sources

Chronic cholesterol depletion increases F-actin levels and induces cytoskeletal reorganization via a dual mechanism

Journal of Lipid Research, 2022
Previous work from us and others has suggested that cholesterol is an important lipid in the context of the organization of the actin cytoskeleton.
Parijat Sarkar, G. Aditya Kumar, Sandeep Shrivastava, Amitabha Chattopadhyay   +3 more
doaj  

Ultrastructure of the actin cytoskeleton [PDF]

Current Opinion in Cell Biology, 2018
The actin cytoskeleton is the primary force-generating machinery in the cell, which can produce pushing (protrusive) forces using energy of actin polymerization and pulling (contractile) forces via sliding of bipolar filaments of myosin II along actin filaments, as well as perform other key functions.
openaire   +3 more sources

Sphingosine-1-phosphate Treatment Improves Cryopreservation Efficiency in Human Mesenchymal Stem Cells

Life, 2023
The actin cytoskeleton plays a crucial role not only in maintaining cell shape and viability but also in homing/engraftment properties of mesenchymal stem cells (MSCs), a valuable source of cell therapy.
Seong-Ju Oh, Chan-Hee Jo, Tae-Seok Kim, Chae-Yeon Hong, Sung-Lim Lee, Young-Hoon Kang, Gyu-Jin Rho   +6 more
doaj   +1 more source

Filamin A in platelets: Bridging the (signaling) gap between the plasma membrane and the actin cytoskeleton

Frontiers in Molecular Biosciences, 2022
Platelets are anucleate cells that are essential for hemostasis and wound healing. Upon activation of the cell surface receptors by their corresponding extracellular ligands, platelets undergo rapid shape change driven by the actin cytoskeleton; this ...
Enoli De Silva, Enoli De Silva, Felix Hong, Felix Hong, Hervé Falet, Hervé Falet, Hugh Kim, Hugh Kim, Hugh Kim   +8 more
doaj   +1 more source