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Quantitative Investigation of the Link between Actin Cytoskeleton Dynamics and Cellular Behavior
Actin cytoskeleton reorganization, which is governed by actin-associated proteins, has a close relationship with the change of cell biological behavior. However, a perceived understanding of how actin mechanical property links to cell biological property
Ying Li, Xiaoru Zhuang, Fuzhou Niu
doaj +1 more source
A pharmacological cocktail for arresting actin dynamics in living cells. [PDF]
The actin cytoskeleton is regulated by factors that influence polymer assembly, disassembly, and network rearrangement. Drugs that inhibit these events have been used to test the role of actin dynamics in a wide range of cellular processes.
Peng, Grace E +2 more
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Dynamics of the Actin Cytoskeleton at Adhesion Complexes
The shape of cells is altered to allow cells to adapt to their changing environments, including responding to internally generated and externally applied force. Force is sensed by cell surface adhesion proteins that are enriched in sites where cells bind
Nicholas M. Cronin, Kris A. DeMali
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The role of the actin cytoskeleton during receptor-mediated endocytosis (RME) has been well characterized in yeast for many years. Only more recently has the interplay between the actin cytoskeleton and RME been extensively explored in mammalian cells ...
Garett Armstrong, Michael F. Olson
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Spatial Organization of the Cytoskeleton enhances Cargo Delivery to Specific Target Areas on the Plasma Membrane of Spherical Cells [PDF]
Intracellular transport is vital for the proper functioning and survival of a cell. Cargo (proteins, vesicles, organelles, etc.) is transferred from its place of creation to its target locations via molecular motor assisted transport along cytoskeletal ...
Hafner, Anne E., Rieger, Heiko
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A model of crosslinker unbinding is implemented in a highly coarse-grained granular model of F-actin cytoskeleton. We employ this specific granular model to study the mechanisms of the compressive responses of F-actin networks.
Tong Li +3 more
doaj +1 more source
The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer [PDF]
The contractile actin-myosin cytoskeleton provides much of the force required for numerous cellular activities such as motility, adhesion, cytokinesis and changes in morphology.
AP Somlyo +62 more
core +1 more source
.: TMEM16A is a major component of Ca2+-activated Cl− channel (CaCC) conductance in murine portal vein smooth muscle cells (mPVSMCs). Here, the regulation of CaCC activity by the actin cytoskeleton was examined in mPVSMCs.
Junya Ohshiro +3 more
doaj +1 more source
The actin cytoskeleton plays a crucial role not only in maintaining cell shape and viability but also in homing/engraftment properties of mesenchymal stem cells (MSCs), a valuable source of cell therapy.
Seong-Ju Oh +6 more
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Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility. [PDF]
BackgroundCell migration plays an important role in many physiological and pathological processes, including immune cell chemotaxis and cancer metastasis.
Liao, Kan, Liu, Yang, Wang, Wenqi
core +2 more sources

