Actin Remodeling Defects Leading to Autoinflammation and Immune Dysregulation
Frontiers in Immunology, 2021 A growing number of monogenic immune-mediated diseases have been related to genes involved in pathways of actin cytoskeleton remodeling. Increasing evidences associate cytoskeleton defects to autoinflammatory diseases and primary immunodeficiencies.
Riccardo Papa +3 more
doaj +1 more source
Quantitative Investigation of the Link between Actin Cytoskeleton Dynamics and Cellular Behavior
Micromachines, 2022 Actin cytoskeleton reorganization, which is governed by actin-associated proteins, has a close relationship with the change of cell biological behavior. However, a perceived understanding of how actin mechanical property links to cell biological property
Ying Li, Xiaoru Zhuang, Fuzhou Niu
doaj +1 more source
Actin reorganization throughout the cell cycle mediated by motor proteins [PDF]
, 2021 Cortical actin networks are highly dynamic and play critical roles in shaping the mechanical properties of cells. The actin cytoskeleton undergoes significant reorganization over the course of the cell cycle, when cortical actin transitions between open patched meshworks, homogeneous distributions, and aligned bundles.
arxiv +1 more source
LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton
Frontiers in Cell and Developmental Biology, 2021 LUZP1 is a centrosomal and actin cytoskeleton-localizing protein that regulates both ciliogenesis and actin filament bundling. As the cytoskeleton and cilia are implicated in metastasis and tumor suppression, we examined roles for LUZP1 in the context of
Laura Bozal-Basterra +12 more
doaj +1 more source
Actin cytoskeleton-dependent regulation of corticotropin-releasing factor receptor heteromers [PDF]
, 2017 Stress responses are highly nuanced and variable, but how this diversity is achieved by modulating receptor function is largely unknown. Corticotropin-releasing factor receptors (CRFRs), class B G protein–coupled receptors, are pivotal in mediating ...
Bhargava, Aditi +7 more
core +1 more source
Actin Cytoskeleton Affects Schwann Cell Migration and Peripheral Nerve Regeneration
Frontiers in Physiology, 2018 Actin cytoskeleton regulates many essential biological functions, including cellular development, shape, polarity, and motility. The organization of actin cytoskeleton has also been associated with numerous physiological and pathological conditions, for ...
Yaxian Wang +3 more
doaj +1 more source
A pharmacological cocktail for arresting actin dynamics in living cells. [PDF]
, 2011 The actin cytoskeleton is regulated by factors that influence polymer assembly, disassembly, and network rearrangement. Drugs that inhibit these events have been used to test the role of actin dynamics in a wide range of cellular processes.
Peng, Grace E +2 more
core +2 more sources
Dynamics of the Actin Cytoskeleton at Adhesion Complexes
Biology, 2021 The shape of cells is altered to allow cells to adapt to their changing environments, including responding to internally generated and externally applied force. Force is sensed by cell surface adhesion proteins that are enriched in sites where cells bind
Nicholas M. Cronin, Kris A. DeMali
doaj +1 more source
A functional link between the actin cytoskeleton and lipid rafts during budding of filamentous influenza virions [PDF]
, 2002 Morphogenesis of influenza virus is a poorly understood process that produces two types of enveloped virion: ∼100-nm spheres and similar diameter filaments that reach 20 μm in length.
Digard, Paul +5 more
core +1 more source
Confocal and video imaging of cytoskeleton dynamics in the leech zygote [PDF]
, 2004 Ooplasmic segregation in the late interphase zygote of the leech Theromyzon trizonare is accomplished by reorganization of an ectoplasmic cytoskeleton formed by polar rings and meridional bands.
Fernández, Juan +2 more
core +1 more source