Results 31 to 40 of about 287,702 (305)

Physical mechanism of the compressive response of F-actin networks: significance of crosslinker unbinding events

Theoretical and Applied Mechanics Letters, 2014
A model of crosslinker unbinding is implemented in a highly coarse-grained granular model of F-actin cytoskeleton. We employ this specific granular model to study the mechanisms of the compressive responses of F-actin networks.
Tong Li, Dean Hu, Prasad K.D.V. Yarlagadda, Yuantong Gu   +3 more
doaj   +1 more source

Nephrin AKTs on actin: The slit diaphragm–actin cytoskeleton signaling network expands [PDF]

, 2008
Regulation and maintenance of the actin cytoskeleton of podocytes has emerged as a critical process for preserving glomerular permselectivity. Signaling through nephrin, a crucial component of the slit diaphragm, can lead to rearrangement of the actin ...
Schlondorff, J.
core   +1 more source

The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer [PDF]

, 2014
The contractile actin-myosin cytoskeleton provides much of the force required for numerous cellular activities such as motility, adhesion, cytokinesis and changes in morphology.
AP Somlyo, B Rafn, C Gaggioli, C Gally, CL Moncrieff, CS Loo, D Pyeon, DA Heerding, DM Pirone, DR Rhodes, ER Gomes, ET Kimchi, F Corpet, G Brunhofer, G Groeger, H Yamaguchi, HI Lowe, I Tan, I Tan, I Tan, I Tan, I Tan, J Schlingemann, J Schwarz, JM Elkins, JM Herbert, K Ando, K Lefort, KE Fisher, L Huo, L Luo, LJ Veer van’t, LR Pearce, LT Lam, M Jacobs, M Uehata, M Vicente-Manzanares, MA Fabian, MA Ginos, Mathieu Unbekandt, MF Olson, MF Olson, Michael F. Olson, N Nakamura, N Rath, P Basu, P Madaule, PL Podolin, R Cmejla, RW Scott, S Balasenthil, S Wang, S Wilkinson, S Yamamoto, SH Choi, SM Kim, T Heikkila, T Leung, T Sumi, X Liu, Y Hao, Y Ng, Y Zhao   +62 more
core   +1 more source

Sphingosine-1-phosphate Treatment Improves Cryopreservation Efficiency in Human Mesenchymal Stem Cells

Life, 2023
The actin cytoskeleton plays a crucial role not only in maintaining cell shape and viability but also in homing/engraftment properties of mesenchymal stem cells (MSCs), a valuable source of cell therapy.
Seong-Ju Oh, Chan-Hee Jo, Tae-Seok Kim, Chae-Yeon Hong, Sung-Lim Lee, Young-Hoon Kang, Gyu-Jin Rho   +6 more
doaj   +1 more source

Chronic cholesterol depletion increases F-actin levels and induces cytoskeletal reorganization via a dual mechanism

Journal of Lipid Research, 2022
Previous work from us and others has suggested that cholesterol is an important lipid in the context of the organization of the actin cytoskeleton.
Parijat Sarkar, G. Aditya Kumar, Sandeep Shrivastava, Amitabha Chattopadhyay   +3 more
doaj  

Molecular simulation approaches to probing the effects of mechanical forces in the actin cytoskeleton [PDF]

arXiv, 2023
In this article we give our perspective on the successes and promise of various molecular and coarse-grained simulation approaches to probing the effect of mechanical forces in the actin cytoskeleton.
arxiv  

Actin Cytoskeleton and Integrin Components Are Interdependent for Slit Diaphragm Maintenance in <i>Drosophila</i> Nephrocytes. [PDF]

Cells
In nephrotic syndrome, the podocyte filtration structures are damaged in a process called foot process effacement. This is mediated by the actin cytoskeleton; however, which actins are involved and how they interact with other filtration components, like
Delaney M, Zhao Y, van de Leemput J, Lee H, Han Z.   +4 more
europepmc   +2 more sources

Filamin A in platelets: Bridging the (signaling) gap between the plasma membrane and the actin cytoskeleton

Frontiers in Molecular Biosciences, 2022
Platelets are anucleate cells that are essential for hemostasis and wound healing. Upon activation of the cell surface receptors by their corresponding extracellular ligands, platelets undergo rapid shape change driven by the actin cytoskeleton; this ...
Enoli De Silva, Enoli De Silva, Felix Hong, Felix Hong, Hervé Falet, Hervé Falet, Hugh Kim, Hugh Kim, Hugh Kim   +8 more
doaj   +1 more source

Quantitative analyses of the plant cytoskeleton reveal underlying organizational principles [PDF]

J R Soc Interface, 2014, 97(11):20140362, 2015
The actin and microtubule cytoskeletons are vital structures for cell growth and development across all species. While individual molecular mechanisms underpinning actin and microtubule dynamics have been intensively studied, principles that govern the cytoskeleton organization remain largely unexplored.
arxiv   +1 more source

Regulation of the Actin Cytoskeleton Organization in Yeast by a Novel Serine/Threonine Kinase Prk1p [PDF]

, 1999
Normal actin cytoskeleton organization in budding yeast requires the function of the Pan1p/ End3p complex. Mutations in PAN1 and END3 cause defects in the organization of actin cytoskeleton and endocytosis. By screening for mutations that can suppress
Adams, Adams, Ayscough, Benton, Bénédetti, Cvrckova, Di Fiore, Doyle, Drubin, Harold, Holtzman, Holtzman, Johnson, Kilmartin, Kron, Lew, Lew, Li, Li, Li, Mulholland, Novick, Rothstein, Sachs, Sikorski, Tang, Tang, Thiagalingam, Waddle, Welch, Wendland, Zheng, Ziman   +32 more
core   +3 more sources