Results 1 to 10 of about 211,322 (248)

Aza-peptides: expectations and reality [PDF]

Proceedings of the Estonian Academy of Sciences, 2022
The replacement of the α-carbon atom in an α-amino acid structure by a nitrogen atom yields alkylcarbazic acids, also known as α-aza amino acids.
Anu Ploom, Anton Mastitski, Meeli Arujõe, Alla Troska, Jaak Järv   +4 more
doaj   +1 more source

A Beginner’s Guide to Osmoprotection by Biostimulants

Plants, 2021
Water is indispensable for the life of any organism on Earth. Consequently, osmotic stress due to salinity and drought is the greatest threat to crop productivity.
David Jiménez-Arias, Francisco J. García-Machado, Sarai Morales-Sierra, Ana L. García-García, Antonio J. Herrera, Francisco Valdés, Juan C. Luis, Andrés A. Borges   +7 more
doaj   +1 more source

Therapeutic Strategies to Activate p53

Pharmaceuticals, 2022
The p53 protein has appropriately been named the “guardian of the genome”. In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of ...
Angelo Aguilar, Shaomeng Wang
doaj   +1 more source

Epigenetic Mechanisms as Emerging Therapeutic Targets and Microfluidic Chips Application in Pulmonary Arterial Hypertension

Biomedicines, 2022
Pulmonary arterial hypertension (PAH) is a disease that progress over time and is defined as an increase in pulmonary arterial pressure and pulmonary vascular resistance that frequently leads to right-ventricular (RV) failure and death.
Linh Ho, Nazir Hossen, Trieu Nguyen, Au Vo, Fakhrul Ahsan   +4 more
doaj   +1 more source

TWO-PHASE MIXING IN TRACTOR DIESEL: THEORY, EXPERIMENT, TECHNICAL SOLUTIONS [PDF]

Volga Region Farmland, 2022
The article is devoted to the problem of improving the power, fuel-economic and environmental performance of tractor diesel engines due to the organization and practical implementation of mixing in two phases. The first phase is carried out in the intake
A.P. Ukhanov, M.V. Ryblov, M.D. Dubin, D.A. Ukhanov   +3 more
doaj   +1 more source

New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds

Pharmaceuticals, 2022
NAD+-dependent deacetylase SIRT1 regulates many different biological processes, thus being involved in pathogenic conditions such as metabolic diseases, neurogenerative disorders and cancer.
Giulia Bononi, Lorenzo Flori, Valentina Citi, Cecilia Acciai, Viviana Nocilla, Alma Martelli, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Lara Testai, Vincenzo Calderone, Filippo Minutolo   +11 more
doaj   +1 more source

The Angiogenic Balance and Its Implications in Cancer and Cardiovascular Diseases: An Overview

Medicina, 2022
Angiogenesis is the process of developing new blood vessels from pre-existing ones. This review summarizes the main features of physiological and pathological angiogenesis and those of angiogenesis activation and inhibition.
Cătălina Ionescu, Bogdan Oprea, Georgeta Ciobanu, Milena Georgescu, Ramona Bică, Garofiţa-Olivia Mateescu, Fidan Huseynova, Veronique Barragan-Montero   +7 more
doaj   +1 more source

Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease

Frontiers in Immunology, 2022
Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor that contains two CARD domains, an RNA helicase domain, and a C-terminal domain.
Hao Wang, Jie Yin, Xinyan Gu, Wenhui Shao, Zhanjun Jia, Zhanjun Jia, Hongbing Chen, Weiwei Xia, Weiwei Xia, Weiwei Xia   +9 more
doaj   +1 more source

Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives

Molecules, 2022
Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase implicated in various biological and pathological processes, including cancer, diabetes, and cardiovascular diseases.
Giulia Bononi, Valentina Citi, Margherita Lapillo, Alma Martelli, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Lara Testai, Vincenzo Calderone, Filippo Minutolo   +9 more
doaj   +1 more source

Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate

Frontiers in Molecular Biosciences, 2023
The opening and closing of voltage-dependent potassium channels is dependent on a tight coupling between movement of the voltage sensing S4 segments and the activation gate.
Eva-Maria Zangerl-Plessl, Wei Wu, Michael C. Sanguinetti, Anna Stary-Weinzinger   +3 more
doaj   +1 more source