Results 21 to 30 of about 211,322 (248)

Comparison of the amine/amino acid activation profiles of the β- and γ-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The β-class carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic bacterium Burkholderia pseudomallei, BpsCAβ, that is responsible for the tropical disease melioidosis was investigated for its activation with natural and non-natural amino acids and ...
Daniela Vullo, Sonia Del Prete, Sameh M. Osman, Fatmah A. S. Alasmary, Zeid AlOthman, William A. Donald, Clemente Capasso, Claudiu T. Supuran   +7 more
doaj   +1 more source

ACE2 ACTIVATION PROMOTES ANTITHROMBOTIC ACTIVITY

The FASEB Journal, 2009
Hyperactivity of the axis ACE/AngII/AT1R of the renin‐angiotensin system is associated with occurrence of acute thrombotic event. Recently a novel concept of a counterrugulatory axis, ACE2/Ang‐(1‐7)/Mas, has emerged. We hypothesized that ACE2 would be protective against thrombosis.
Rodrigo A, Fraga-Silva, Brian S, Sorg, Mamta, Wankhede, Casey, Dedeugd, Joo Y, Jun, Matthew B, Baker, Yan, Li, Ronald K, Castellano, Michael J, Katovich, Mohan K, Raizada, Anderson J, Ferreira   +10 more
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Transcriptional activators and activation mechanisms [PDF]

Protein & Cell, 2007
Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a few selected issues in understanding activator functions and activation mechanisms.
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Active learning activities

Septentrio Conference Series, 2020
First year architecture students are introduced to the library by taking part in an “Escape Room” activity in the KTH library. The aim of this initiative is to introduce the students to the library space and the library's resources in an interactive and playful way and to enable them to learn and reflect upon their learning within the frame of an ...
Lenita Brodin Berggren, Ika Jorum
openaire   +3 more sources

The first activation study of the β-carbonic anhydrases from the pathogenic bacteria Brucella suis and Francisella tularensis with amines and amino acids

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The activation of the β-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacteria Brucella suis and Francisella tularensis with amine and amino acids was investigated. BsuCA 1 was sensitive to activation with amino acids and amines, whereas FtuCA was
Andrea Angeli, Sonia Del Prete, Mariana Pinteala, Stelian S. Maier, William A. Donald, Bogdan C. Simionescu, Clemente Capasso, Claudiu T. Supuran   +7 more
doaj   +1 more source

Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Carbonic anhydrases (CAs, EC 4.2.1.1) activators were shown to be involved in memory enhancement and learning in animal models of cognition. Here we investigated the CA activating effects of a large series of histamine based compounds, including ...
Gustavo Provensi, Alessio Nocentini, Maria Beatrice Passani, Patrizio Blandina, Claudiu T. Supuran   +4 more
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Active colloidal molecules in activity gradients [PDF]

Physical Review E, 2022
We consider a rigid assembly of two active Brownian particles, forming an active colloidal dimer, in a gradient of activity. We show analytically that depending on the relative orientation of the two particles the active dimer accumulates in regions of either high or low activity, corresponding to, respectively, chemotaxis and antichemotaxis.
Hidde D. Vuijk, Sophie Klempahn, Holger Merlitz, Jens-Uwe Sommer, Abhinav Sharma   +4 more
openaire   +3 more sources

Silica Fume as Precursor in the Development of Sustainable and High-Performance MK-Based Alkali-Activated Materials Reinforced With Short PVA Fibers

Frontiers in Materials, 2019
Alkali-activated materials (AAM) are currently the subject of increasing interest and research, mainly due to the possibility of reducing the carbon dioxide (CO2) emissions in their production when compared to Portland cement (PC) and still achieve ...
Raquel P. Batista, Ana Carolina C. Trindade, Paulo H. R. Borges, Flávio de A. Silva   +3 more
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Active learning enabled activity recognition [PDF]

Pervasive and Mobile Computing, 2016
© 2016 IEEE, 2016 IEEE International Conference on Pervasive Computing and Communications (PerCom)
Hossain, H M Sajjad, Roy, Nirmalya, Khan, Md Abdullah Al Hafiz   +2 more
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Inhibition of α-, β-, γ-, and δ-carbonic anhydrases from bacteria and diatoms with N′-aryl-N-hydroxy-ureas

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The inhibition of α-, β-, γ-, and δ-class carbonic anhydrases (CAs, EC 4.2.1.1) from bacteria (Vibrio cholerae and Porphyromonas gingivalis) and diatoms (Thalassiosira weissflogii) with a panel of N’-aryl-N-hydroxy-ureas is reported. The α-/β-CAs from V.
Emanuela Berrino, Murat Bozdag, Sonia Del Prete, Fatmah A. S. Alasmary, Linah S. Alqahtani, Zeid AlOthman, Clemente Capasso, Claudiu T. Supuran   +7 more
doaj   +1 more source