Results 1 to 10 of about 1,622,334 (202)
Neuromuscular Active Zone Structure and Function in Healthy and Lambert-Eaton Myasthenic Syndrome States [PDF]
Biomolecules, 2022 The mouse neuromuscular junction (NMJ) has long been used as a model synapse for the study of neurotransmission in both healthy and disease states of the NMJ.
Scott P. Ginebaugh +3 more
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Hypothesis Relating the Structure, Biochemistry and Function of Active Zone Material Macromolecules at a Neuromuscular Junction [PDF]
Frontiers in Synaptic Neuroscience, 2022 This report integrates knowledge of in situ macromolecular structures and synaptic protein biochemistry to propose a unified hypothesis for the regulation of certain vesicle trafficking events (i.e., docking, priming, Ca2+-triggering, and membrane fusion)
Joseph A. Szule
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Visualizing Presynaptic Active Zones and Synaptic Vesicles [PDF]
Frontiers in Synaptic Neuroscience, 2022 The presynaptic active zone (AZ) of chemical synapses is a highly dynamic compartment where synaptic vesicle fusion and neurotransmitter release take place.
Manfred Heckmann, Martin Pauli
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Assembly of the presynaptic active zone. [PDF]
Curr Opin Neurobiol, 2020 In a presynaptic nerve terminal, the active zone is composed of sophisticated protein machinery that enables secretion on a submillisecond time scale and precisely targets it toward postsynaptic receptors. The past two decades have provided deep insight into the roles of active zone proteins in exocytosis, but we are only beginning to understand how a ...
Emperador-Melero J, Kaeser PS.
europepmc +4 more sources
ELKS active zone proteins as multitasking scaffolds for secretion [PDF]
Open Biology, 2018 Synaptic vesicle exocytosis relies on the tethering of release ready vesicles close to voltage-gated Ca2+ channels and specific lipids at the future site of fusion.
Richard G. Held, Pascal S. Kaeser
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Rapid active zone remodeling consolidates presynaptic potentiation. [PDF]
Nat Commun, 2019 AbstractSynaptic transmission is mediated by neurotransmitter release at presynaptic active zones (AZs) followed by postsynaptic neurotransmitter detection. Plastic changes in transmission maintain functionality during perturbations and enable memory formation.
Böhme MA +17 more
europepmc +8 more sources
Serine–Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2 [PDF]
Cells, 2019 Neurons release neurotransmitters at a specialized region of the presynaptic membrane, the active zone (AZ), where a complex meshwork of proteins organizes the release apparatus.
Duxan Arancibia +10 more
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Applied Sciences, 2023 This study investigated the indoor environment quality (IEQ) of eight office buildings of interest due to: (a) their location at the region of Western Macedonia, Greece, which is an area characterized by aggravated air quality and is currently in a ...
Ioannis Sakellaris +6 more
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Effectiveness of the IoT in Regional Energy Transition: The Smart Bin Case Study
Recycling, 2023 As part of the European Green Deal, the EU aims to become climate-neutral and reach net-zero greenhouse gas emissions by 2050. Lignite has long dominated the electricity system of Greece, providing cheap and reliable energy, given the abundant and low ...
Dimitris Ziouzios, Minas Dasygenis
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Frontiers in Cellular Neuroscience, 2023 Synaptic transmission relies on presynaptic neurotransmitter (NT) release from synaptic vesicles (SVs) and on NT detection by postsynaptic receptors.
Andreas T. Grasskamp +8 more
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