Results 51 to 60 of about 1,622,433 (301)

Rab Interacting Molecules 2 and 3 Directly Interact with the Pore-Forming CaV1.3 Ca2+ Channel Subunit and Promote Its Membrane Expression

Frontiers in Cellular Neuroscience, 2017
Rab interacting molecules (RIMs) are multi-domain proteins that positively regulate the number of Ca2+ channels at the presynaptic active zone (AZ). Several molecular mechanisms have been demonstrated for RIM-binding to components of the presynaptic Ca2+
Maria M. Picher, Maria M. Picher, Maria M. Picher, Ana-Maria Oprişoreanu, SangYong Jung, SangYong Jung, SangYong Jung, Katrin Michel, Susanne Schoch, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +12 more
doaj   +1 more source

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones

eLife, 2022
Active zones consist of protein scaffolds that are tightly attached to the presynaptic plasma membrane. They dock and prime synaptic vesicles, couple them to voltage-gated Ca2+ channels, and direct neurotransmitter release toward postsynaptic receptor ...
Chao Tan, Giovanni de Nola, Claire Qiao, Cordelia Imig, Richard T Born, Nils Brose, Pascal S Kaeser   +6 more
doaj   +1 more source

Trapping Solids at the Inner Edge of the Dead Zone: 3-D Global MHD Simulations

, 2010
The poorly-ionized interior of the protoplanetary disk is the location where dust coagulation processes may be most efficient. However even here, planetesimal formation may be limited by the loss of solid material through radial drift, and by collisional
Balbus, Balbus, Beck, Benz, Blum, Blum, Bodo, Brandenburg, Brauer, Brauer, Brauer, Dziourkevitch, Fleming, Fromang, Fromang, Fromang, Fromang, Fromang, Gammie, Glassgold, Goldreich, Guan, H. Klahr, Haghighipour, Hawley, Hawley, Ida, Igea, Ilgner, Johansen, Klahr, Kretke, Kretke, Lesur, Lightman, Lyra, M. Flock, Masset, N. Dzyurkevich, N. J. Turner, Nakagawa, Oppenheimer, Piran, Poppe, Sano, Sano, Sano, Sano, Schlaufman, Semenov, Steinacker, Takeuchi, Tanaka, Th. Henning, Turner, Turner, Ward, Wardle, Weidenschilling, Wünsch, Wünsch, Youdin   +61 more
core   +1 more source

Unc-51 Controls Active Zone Density and Protein Composition by Downregulating ERK Signaling [PDF]

, 2009
Efficient synaptic transmission requires the apposition of neurotransmitter release sites opposite clusters of postsynaptic neurotransmitter receptors. Transmitter is released at active zones, which are composed of a large complex of proteins necessary ...
DiAntonio Aaron, Furukubo-Tokunaga Katsuo, Mochizuki Hiroaki, P. Wairkar Yogesh, Toda Hirofumi, Tomoda Toshifumi, 古久保 - 徳永 克男   +6 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Variations of Solar Non-axisymmetric Activity [PDF]

, 2013
The temporal behaviour of solar active longitudes has been examined by using two sunspot catalogues, the Greenwich Photoheliographic Results (GPR) and the Debrecen Photoheliographic Data (DPD).
Baranyi, Tünde, Gyenge, Norbert, Ludmány, András   +2 more
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Cryptochrome Is a Regulator of Synaptic Plasticity in the Visual System of Drosophila melanogaster

Frontiers in Molecular Neuroscience, 2017
Drosophila CRYPTOCHROME (CRY) is a blue light sensitive protein with a key role in circadian photoreception. A main feature of CRY is that light promotes an interaction with the circadian protein TIMELESS (TIM) resulting in their ubiquitination and ...
Milena Damulewicz, Gabriella M. Mazzotta, Elena Sartori, Ezio Rosato, Rodolfo Costa, Elzbieta M. Pyza   +5 more
doaj   +1 more source

Active zone compaction correlates with presynaptic homeostatic potentiation

Cell Reports, 2021
Summary: Neurotransmitter release is stabilized by homeostatic plasticity. Presynaptic homeostatic potentiation (PHP) operates on timescales ranging from minute- to life-long adaptations and likely involves reorganization of presynaptic active zones (AZs)
Achmed Mrestani, Martin Pauli, Philip Kollmannsberger, Felix Repp, Robert J. Kittel, Jens Eilers, Sören Doose, Markus Sauer, Anna-Leena Sirén, Manfred Heckmann, Mila M. Paul   +10 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source