Results 61 to 70 of about 1,622,433 (301)
Establishing synthetic ribbon-type active zones in a heterologous expression system
eLifeEncoding of several sensory modalities into neural signals is mediated by ribbon synapses. The synaptic ribbon tethers synaptic vesicles at the presynaptic active zone (AZ) and may act as a super-scaffold organizing AZ topography.
Rohan Kapoor +7 more
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
High frequency stimulation activates hot spots of spontaneous synaptic transmission
Frontiers in Synaptic NeuroscienceNeuronal transmitters are released at the morphological specializations known as active zones (AZs). Transmitters can be released either in response to a stimulus or spontaneously, and spontaneous transmission is a vital component of neuronal ...
Herson Astacio, Maria Bykhovskaia
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Synaptic Ribbon Active Zones in Cone Photoreceptors Operate Independently from One Another
Frontiers in Cellular Neuroscience, 2017 Cone photoreceptors depolarize in darkness to release glutamate-laden synaptic vesicles. Essential to release is the synaptic ribbon, a structure that helps organize active zones by clustering vesicles near proteins that mediate exocytosis, including ...
Justin J. Grassmeyer +3 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
eLife, 2016 Neurotransmitter release is mediated by the fast, calcium-triggered fusion of synaptic vesicles with the presynaptic plasma membrane, followed by endocytosis and recycling of the membrane of synaptic vesicles.
Mahdokht Kohansal-Nodehi +4 more
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Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Frontiers in Cellular NeuroscienceOlfactory sensory neurons (OSNs) detect odours at a wide range of intensities. In Drosophila, volatile compounds bind to specific odorant receptors (ORs), which tune the sensitivity of chemoreception.
Namrata Acharya +7 more
doaj +1 more source
The tortoise and the hare revisited
eLife, 2013 Optogenetics and electron microscopy reveal an ultrafast mode of synaptic vesicle recycling, adding a new twist to a 40-year-old controversy.
Natalia L Kononenko +2 more
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Note on the "Dead Zone" in Layered Accretion Models
, 2002 Current layered accretion models neglect the properties of the ``dead zone''. However, as argued here from simple considerations, the thickness of this zone is a critical quantity when the disc is in hydrostatic equilibrium.
Hure, J. -M.
core +1 more source