Results 1 to 10 of about 60,949 (235)

Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. [PDF]

, 2014
In the present study, we investigate whether the FOXO1 transcription factor modulates activin signaling in pituitary gonadotropes. Our studies show that overexpression of constitutively active FOXO1 decreases activin induction of murine Fshb gene ...
Arriola, David J, Park, Chung Hyun, Rivera, Alissa J, Skarra, Danalea V, Thackray, Varykina G   +4 more
core   +14 more sources

Activin B promotes the initiation and progression of liver fibrosis

Hepatology Communications, 2022
The role of activin B, a transforming growth factor β (TGFβ) superfamily cytokine, in liver health and disease is largely unknown. We aimed to investigate whether activin B modulates liver fibrogenesis.
Yan Wang, Matthew Hamang, Alexander Culver, Huaizhou Jiang, Jennifer Yanum, Veronica Garcia, Joonyong Lee, Emily White, Praveen Kusumanchi, Naga Chalasani, Suthat Liangpunsakul, Benjamin C. Yaden, Guoli Dai   +12 more
doaj   +1 more source

Activin A Reduces GIRK Current to Excite Dentate Gyrus Granule Cells

Frontiers in Cellular Neuroscience, 2022
Activin A, a member of the TGF-β family, is recognized as a multifunctional protein in the adult brain with a particular impact on neuronal circuits associated with cognitive and affective functions.
Fang Zheng, Maria Jesus Valero-Aracama, Natascha Schaefer, Christian Alzheimer   +3 more
doaj   +1 more source

Low miR-143/miR-145 Cluster Levels Induce Activin A Overexpression in Oral Squamous Cell Carcinomas, Which Contributes to Poor Prognosis. [PDF]

PLoS ONE, 2015
Deregulated expression of activin A is reported in several tumors, but its biological functions in oral squamous cell carcinoma (OSCC) are unknown. Here, we investigate whether activin A can play a causal role in OSCCs.
Andreia Bufalino, Nilva K Cervigne, Carine Ervolino de Oliveira, Felipe Paiva Fonseca, Priscila Campioni Rodrigues, Carolina Carneiro Soares Macedo, Lays Martin Sobral, Marcia Costa Miguel, Marcio Ajudarte Lopes, Adriana Franco Paes Leme, Daniel W Lambert, Tuula A Salo, Luiz Paulo Kowalski, Edgard Graner, Ricardo D Coletta   +14 more
doaj   +1 more source

Urinary Activin A: A Novel Biomarker for Human Acute Kidney Injury

Diagnostics, 2022
Activin is a multifunctional cytokine belonging to the transforming growth factor (TGF)-β superfamily that regulates the growth and differentiation of cells in various organs.
Izumi Nagayama, Akito Maeshima, Daisuke Nagata   +2 more
doaj   +1 more source

Role of stromal activin A in human pancreatic cancer and metastasis in mice

Scientific Reports, 2021
Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains one of the cancers with the highest mortality rates. Activin A has been implicated in colon cancer and its stroma but its role in the stroma of PDAC has not been ...
Georgina Mancinelli, Carolina Torres, Nancy Krett, Jessica Bauer, Karla Castellanos, Ron McKinney, David Dawson, Grace Guzman, Rosa Hwang, Sam Grimaldo, Paul Grippo, Barbara Jung   +11 more
doaj   +1 more source

The Impact of Activin A on Fetal Gonocytes: Chronic Versus Acute Exposure Outcomes

Frontiers in Endocrinology, 2022
Activin A, a TGFβ superfamily member, is important for normal testis development through its actions on Sertoli cell development. Our analyses of altered activin A mouse models indicated gonocyte abnormalities, implicating activin A as a key determinant ...
Sarah C. Moody, Sarah C. Moody, Penny A. F. Whiley, Penny A. F. Whiley, Patrick S. Western, Patrick S. Western, Kate L. Loveland, Kate L. Loveland   +7 more
doaj   +1 more source

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors

Biomolecules, 2020
Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway.
Oddrun Elise Olsen, Hanne Hella, Samah Elsaadi, Carsten Jacobi, Erik Martinez-Hackert, Toril Holien   +5 more
doaj   +1 more source

Activin A regulates activation of mouse neutrophils by Smad3 signalling [PDF]

Open Biology, 2017
Activin A, a member of the transforming growth factor beta superfamily, acts as a pro-inflammatory factor in acute phase response, and influences the pathological progress of neutrophil-mediated disease.
Yan Qi, Jingyan Ge, Chunhui Ma, Na Wu, Xueling Cui, Zhonghui Liu   +5 more
doaj   +1 more source

Sequential Treatment with Activin and Hepatocyte Growth Factor Induces FOXM1 to Promote Colorectal Cancer Liver Metastasis

Canadian Journal of Gastroenterology and Hepatology, 2022
Background. Cancer stem cells (CSCs) are involved in liver metastasis in colorectal cancer (CRC). Activin and hepatocyte growth factor (HGF) are important regulators of stem cell properties.
Hong Peng, Ting Ye, Lei Deng, Xiaofang Yang, Zheng Jiang, Jinjun Guo   +5 more
doaj   +1 more source