Results 121 to 130 of about 60,949 (235)

Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING

Frontiers in Immunology
The transforming growth factor-β (TGF-β) family member activin A (hereafter Activin-A) is overexpressed in many cancer types, often correlating with cancer-associated cachexia and poor prognosis.
Katarina Pinjusic, Giovanna Ambrosini, Giovanna Ambrosini, Joao Lourenco, Nadine Fournier, Christian Iseli, Christian Iseli, Nicolas Guex, Nicolas Guex, Olga Egorova, Sina Nassiri, Daniel B. Constam   +11 more
doaj   +1 more source

Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis, Andrea Nüesch, Joseph Snuggs, Christine Lyn Le Maitre, Leonidas G. Alexopoulos   +4 more
wiley   +1 more source

Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis [PDF]

, 1993
To contribute to an understanding of the roles and mechanisms of action of Wnts in early vertebrate development, we have characterized the normal expression of Xenopus laevis Wnt-5A, and investigated the consequences of misexpression of this putative ...
Campbell, Robert M., Christian, Jan L., Fraser, Scott E., McGrew, L. Lynn, Moon, Randall T., Shih, John   +5 more
core  

Molecular Engineering of the Helminth TGF‐β Mimetics, TGM1 and TGM4, Reveals a Novel Antagonist of TGF‐β Signaling in Fibroblasts

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
The helminth TGF‐β mimic TGM4 activates SMAD signaling in macrophages and T cells through canonical TGF‐β receptors and the CD44 co‐receptor, through Domains 1–5 (D1‐5). In fibroblasts, which express lower levels of CD44, TGM4 binds but does not transduce a signal; furthermore, it inhibits activation by agonist ligands such as TGF‐β itself, in a manner
Kyle T. Cunningham, Claire Ciancia, Tiffany Campion, Maarten van Dinther, Nadia Davis, Anja Duffy, Anna L. L. Heawood, Luke Power, Anna Sanders, Shashi P. Singh, Danielle J. Smyth, Elizabeth Thompson, Ruby White, Andrew P. Hinck, Peter ten Dijke, Rick M. Maizels   +15 more
wiley   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

The Mediating Effect of Inflammatory Biomarkers in the Associations Between Sarcoidosis and Incident Ischemic Stroke: A Prospective Cohort Study

Brain and Behavior, Volume 16, Issue 4, April 2026.
Can invasive suckermouth catfish, Hypostomus plecostomus, be used as fishmeal? A potential solution to eradicate it from the Buriganga River, Bangladesh ABSTRACT Background and objective: Sarcoidosis, characterized by granulomatous inflammation across multiple systems, has an unclear connection with ischemic stroke and shared molecular pathways.
Zihong Bai, Wenming Shao, Xiaxuan Huang, Shanyuan Tan, Yitong Ling, Shiqi Yuan, Xinya Li, Jun Lyu   +7 more
wiley   +1 more source

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Local complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Hui Zhang, Ram Raj Prasad, Sushil Kumar, Min Li, Dallas Jones, Cheng‐Jun Hu, Claudia Mickael, Yen‐Rei Yu, Rubin M. Tuder, Kurt R. Stenmark   +9 more
wiley   +1 more source

The Importance of Liver‐Lung Communication in Pulmonary Vascular Diseases

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Schematic depicting the key drivers of liver‐lung communication in pulmonary vascular diseases, including hepatic dysfunction, portosystemic shunting, and gut microbial dysbiosis, which together drive pulmonary vascular remodeling. ABSTRACT In normal health, the liver and lungs enjoy a close anatomic, physiologic, and functional relationship.
Navneet Singh, Hilary M. DuBrock, Sasha Z. Prisco, Zhiyu Dai, Qi Zheng, Michael B. Fallon, Thenappan Thenappan, Corey E. Ventetuolo, Arun Jose   +8 more
wiley   +1 more source

How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans Progressiva

Biomolecules
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by episodic yet cumulative heterotopic ossification (HO) of skeletal muscles, tendons, ligaments, and fascia. FOP arises from missense mutations in Activin Receptor type
Dushyanth Srinivasan, Martin Arostegui, Erich J. Goebel, Kaitlin N. Hart, Senem Aykul, John B. Lees-Shepard, Vincent Idone, Sarah J. Hatsell, Aris N. Economides   +8 more
doaj   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source