Results 11 to 20 of about 73,976 (284)

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors

Biomolecules, 2020
Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway.
Oddrun Elise Olsen, Hanne Hella, Samah Elsaadi, Carsten Jacobi, Erik Martinez-Hackert, Toril Holien   +5 more
doaj   +2 more sources

The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy

Journal of Cachexia, Sarcopenia and Muscle, 2019
Background Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous activin causes cachexia in mice.
Xiaoling Zhong, Marianne Pons, Christophe Poirier, Yanlin Jiang, Jianguo Liu, George E. Sandusky, Safi Shahda, Attila Nakeeb, C. Max Schmidt, Michael G. House, Eugene P. Ceppa, Nicholas J. Zyromski, Yunlong Liu, Guanglong Jiang, Marion E. Couch, Leonidas G. Koniaris, Teresa A. Zimmers   +16 more
doaj   +2 more sources

Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy

BMJ Open Diabetes Research & Care, 2019
Objective Activin A, an inflammatory mediator implicated in cellular senescence-induced adipose tissue dysfunction and profibrotic kidney injury, may become a new target for the treatment of diabetic kidney disease (DKD) and chronic kidney diseases.
Hui Tang, Lilach O Lerman, Xiaohui Bian, Tomás P Griffin, Xiangyang Zhu, Md Nahidul Islam, Sabena M Conley, Alfonso Eirin, Paula M O’Shea, Allyson K Palmer, Sandra M Herrmann, Ramila A Mehta, John R Woollard, Andrew D Rule, James L Kirkland, Tamar Tchkonia, Stephen C Textor, Matthew D Griffin, LaTonya J Hickson   +18 more
doaj   +2 more sources

Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer

Scientific Reports, 2017
Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed in isolation ...
Jonas J. Staudacher, Jessica Bauer, Arundhati Jana, Jun Tian, Timothy Carroll, Georgina Mancinelli, Özkan Özden, Nancy Krett, Grace Guzman, David Kerr, Paul Grippo, Barbara Jung   +11 more
doaj   +2 more sources

Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages

EMBO Molecular Medicine, 2016
Activin has emerged as an important player in different types of cancer, but the underlying mechanisms are largely unknown. We show here that activin overexpression is an early event in murine and human skin tumorigenesis. This is functionally important,
Maria Antsiferova, Aleksandra Piwko‐Czuchra, Michael Cangkrama, Mateusz Wietecha, Dilara Sahin, Katharina Birkner, Valerie C Amann, Mitchell Levesque, Daniel Hohl, Reinhard Dummer, Sabine Werner   +10 more
doaj   +2 more sources

Identification of Urinary Activin A as a Novel Biomarker Reflecting the Severity of Acute Kidney Injury [PDF]

Scientific Reports, 2018
学位記番号 ...
Takahashi, Shunsuke, タカハシ, シュンスケ, 高橋, 駿介   +2 more
core   +2 more sources

Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension

Circulation, 2023
Background: Activins are novel therapeutic targets in pulmonary arterial hypertension (PAH). We therefore studied whether key members of the activin pathway could be used as PAH biomarkers.
C. Guignabert, L. Savale, A. Boucly, R. Thuillet, L. Tu, M. Ottaviani, Christopher J. Rhodes, P. De Groote, G. Prévôt, E. Bergot, A. Bourdin, L. Howard, E. Fadel, A. Beurnier, A. Roche, M. Jevnikar, X. Jaïs, D. Montani, M. Wilkins, O. Sitbon, M. Humbert   +20 more
semanticscholar   +1 more source

Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin

Journal of Cachexia, Sarcopenia and Muscle, 2022
Cachexia is frequent, deadly, and untreatable for patients with pancreatic ductal adenocarcinoma (PDAC). The reproductive hormone and cytokine Activin is a mediator of PDAC cachexia, and Activin receptor targeting was clinically tested for cancer ...
Xiaoling Zhong, Ashok Narasimhan, L. Silverman, A. Young, S. Shahda, Sheng Liu, J. Wan, Yunlong Liu, L. Koniaris, T. Zimmers   +9 more
semanticscholar   +1 more source

Activin A alleviates neuronal injury through inhibiting cGAS-STING-mediated autophagy in mice with ischemic stroke

Journal of Cerebral Blood Flow and Metabolism, 2022
Activin A plays an essential role in ischemic stroke as a well-known neuroprotective factor. We previously reported that Activin A could promote white matter remyelination.
Meilian Liu, Yudie Li, Song Han, Hongyu Wang, Junfa Li   +4 more
semanticscholar   +1 more source

An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension

Nature Communications, 2021
Pulmonary arterial hypertension is a progressive fatal disease that is characterized by pathological pulmonary artery remodeling, in which endothelial cell dysfunction is critically involved.
G. Ryanto, K. Ikeda, K. Miyagawa, L. Tu, C. Guignabert, M. Humbert, Tomoyuki Fujiyama, M. Yanagisawa, K. Hirata, N. Emoto   +9 more
semanticscholar   +1 more source