Results 41 to 50 of about 73,976 (284)

Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis [PDF]

, 2017
This work was supported by British Heart Foundation (BHF Project Grant no PG/13/23/30080 to B.A.A and S.H.), Biotechnology and Biological Sciences Research Council (BB/M001695/1 to S.H.) and the University of Aberdeen (for A.T.L).
Afouda, Boni A, De Paiva Alves, Eduardo, Hoppler, Stefan, Lynch, Adam T   +3 more
core   +1 more source

Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer

Cancer immunology research, 2020
Activin A and TGFβ can shape the breast cancer tumor microenvironment after radiotherapy. Dual blockade of activin A and TGFβ reverses radiotherapy-induced Treg increases and boosts antitumor responses, highlighting potential targetable factors for ...
M. De Martino, C. Daviaud, J. Diamond, J. Kraynak, A. Alard, S. Formenti, L. Miller, S. Demaria, C. Vanpouille-Box   +8 more
semanticscholar   +1 more source

Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids

Molecular Metabolism, 2023
Objective: The liver is a central regulator of energy metabolism exerting its influence both through intrinsic processing of substrates such as glucose and fatty acid as well as by secreting endocrine factors, known as hepatokines, which influence ...
John D. Griffin, Joanne M. Buxton, Jeffrey A. Culver, Robert Barnes, Emily A. Jordan, Alexis R. White, Stephen E. Flaherty, Barbara Bernardo, Trenton Ross, Kendra K. Bence, Morris J. Birnbaum   +10 more
doaj   +1 more source

Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [PDF]

, 2006
The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its essential role in maintaining pluripotency, Oct4 expression is
Adjaye, J., Babaie, Y., Brink, T., Burdon, T., Greber, B., Groth, D., Herwig, R., Lehrach, H., Wruck, W.   +8 more
core   +2 more sources

Activin type II receptor signaling in cardiac aging and heart failure

Science Translational Medicine, 2019
Activin type II receptor signaling regulates cardiac function in aging and heart failure by modulating proteasome-dependent SERCA2a degradation. Aging, activins, and heart failure Age is a risk factor for heart failure, but the underlying mechanisms ...
Jason D. Roh, R. Hobson, Vinita Chaudhari, P. Quintero, Ashish S. Yeri, M. Benson, C. Xiao, Daniel A. Zlotoff, Vassilios J. Bezzerides, N. Houstis, Colin Platt, F. Damilano, B. Lindman, S. Elmariah, Michael Biersmith, Se-Jin Lee, C. Seidman, J. Seidman, Robert E. Gerszten, E. Lach‐Trifilieff, D. Glass, A. Rosenzweig   +21 more
semanticscholar   +1 more source

Activin/follistatin system in grass carp pituitary cells: - Regulation by local release of growth hormone and luteinizing hormone and its functional role in growth hormone synthesis and secretion.

PLoS ONE, 2017
Gonadotrophin regulation by activin/follistatin system is well-documented, but the corresponding effect on growth hormone (GH) has not been fully characterized and with little information available in lower vertebrates, especially in fish models.
Roger S K Fung, Jin Bai, Karen W Y Yuen, Anderson O L Wong   +3 more
doaj   +1 more source

Enhanced differentiation of human embryonic stem cells towards definitive endoderm on ultrahigh aspect ratio nanopillars [PDF]

, 2015
Differentiation of human embryonic stem cells is widely studied as a potential unlimited source for cell replacement therapy to treat degenerative diseases such as diabetes.
Dufva, Martin, Gadegaard, Nikolaj, Hansson, Mattias, Holzmann Rasmussen, Camilla, McMeeking, Robert M., Petersen, Dorthe Roenn, Reynolds, Paul   +6 more
core   +2 more sources

Activin-A in the regulation of immunity in health and disease.

Journal of Autoimmunity, 2019
The TGF-β superfamily of cytokines plays pivotal roles in the regulation of immune responses protecting against or contributing to diseases, such as, allergy, autoimmunity and cancer. Activin-A, a member of the TGF-β superfamily, was initially identified
I. Morianos, G. Papadopoulou, M. Semitekolou, G. Xanthou   +3 more
semanticscholar   +1 more source

Activin A as a Novel Chemokine Induces Migration of L929 Fibroblasts by ERK Signaling in Microfluidic Devices

Frontiers in Cell and Developmental Biology, 2021
Activin A, a member of the transforming growth factor-beta (TGF-β) superfamily, contributes to tissue healing and fibrosis. As the innate tissue cells, fibroblasts also play an important role in wound healing and fibrosis. Herein, this study was aimed to
Lingling Jiang, Lingling Jiang, Yan Qi, Xianghan Kong, Runnan Wang, Jianfei Qi, Francis Lin, Xueling Cui, Zhonghui Liu   +8 more
doaj   +1 more source

Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva

Nature Communications, 2018
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disorder characterized by progressive and profoundly disabling heterotopic ossification (HO).
John B. Lees-Shepard, Masa Yamamoto, Arpita A. Biswas, Sean J. Stoessel, Sarah-Anne E Nicholas, C. A. Cogswell, Parvathi M. Devarakonda, Michael J Schneider, Samantha M. Cummins, Nicholas P. Legendre, Shoko Yamamoto, V. Kaartinen, Jeffrey W. Hunter, D. Goldhamer   +13 more
semanticscholar   +1 more source