Results 51 to 60 of about 73,976 (284)

Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells [PDF]

, 1997
To gain more insight in the mechanism of action of inhibin, we studied the effect of inhibin on activin signaling in Chinese hamster ovary cells.
Jong, F.H. (Frank) de, Martens, J.W.M. (John), McLuskey, A., Schaik, R.H.N. (Ron) van, Themmen, A.P.N. (Axel), Timmerman, M.A. (Marianna), Winter, J.P. (Johan) de   +6 more
core   +3 more sources

Acute Intermittent Hypoxia Exerts Beneficial Effects and Promotes Repair in Male Mice in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. [PDF]

Glia
Acute intermittent hypoxia is a novel, noninvasive therapy that shows promising and similar beneficial repair and remyelination following demyelination in male experimental autoimmune encephalomyelitis, as was previously shown in female mice. ABSTRACT Multiple sclerosis (MS) affects women more frequently than men, but the disease progresses more ...
Tokarska N, Roberts J, Koralage SR, Naniong JMA, Johnston JM, Wei Z, Verge VMK.   +6 more
europepmc   +2 more sources

15-deoxy-Δ12,14-prostaglandin J2 Down-Regulates Activin-Induced Activin Receptor, Smad, and Cytokines Expression via Suppression of NF-κB and MAPK Signaling in HepG2 Cells

PPAR Research, 2013
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) and activin are implicated in the control of apoptosis, cell proliferation, and inflammation in cells. We examined both the mechanism by which 15d-PGJ2 regulates the transcription of activin-induced activin ...
Seung-Won Park, Chunghee Cho, Byung-Nam Cho, Youngchul Kim, Tae Won Goo, Young Il Kim   +5 more
doaj   +1 more source

Activin A promotes neuronal differentiation of cerebrocortical neural progenitor cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Activin A is a protein that participates principally in reproductive functions. In the adult brain, Activin is neuroprotective, but its role in brain development is still elusive.
Griselda Rodríguez-Martínez, Anayansi Molina-Hernández, Iván Velasco   +2 more
doaj   +1 more source

Systemic activation of activin A signaling causes chronic kidney disease-mineral bone disorder [PDF]

, 2018
The high cardiovascular mortality associated with chronic kidney disease (CKD) is caused in part by the CKD-mineral bone disorder (CKD-MBD) syndrome.
Sugatani, Toshifumi
core   +2 more sources

Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes [PDF]

, 2013
Background Activin A is a pleiotrophic regulatory cytokine, the ablation of which is neonatal lethal. Healthy human alveolar macrophages (AMs) constitutively express activin A, but AMs of patients with pulmonary alveolar proteinosis (PAP) are ...
Barna, Barbara P, Dalrymple, Heidi, Kavuru, Mani S, Malur, Achut G, Malur, Anagha, NC DOCKS at East Carolina University, Thomassen, Mary Jane   +6 more
core   +1 more source

Activin-A Induces Fewer, but Larger Osteoclasts From Monocytes in Both Healthy Controls and Fibrodysplasia Ossificans Progressiva Patients

Frontiers in Endocrinology, 2020
Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disease characterized by heterotopic ossification (HO) that occurs in muscle tissue, tendons, and ligaments.
Ton Schoenmaker, Esmée Botman, Merve Sariyildiz, Dimitra Micha, Coen Netelenbos, Nathalie Bravenboer, Angele Kelder, E. Marelise W. Eekhoff, Teun J. De Vries   +8 more
doaj   +1 more source

Clinical Implication of Targeting of Cancer Stem Cells [PDF]

, 2012
The existence of cancer stem cells (CSCs) is receiving increasing interest particularly due to its potential ability to enter clinical routine. Rapid advances in the CSC field have provided evidence for the development of more reliable anticancer ...
Al-Hajj M, Bao S, Bardsley MR, Barlogie B, Bentzen SM, Bertout JA, Blazek ER, Bruns CJ, Brunsvig PF, C.J. Bruns, Cao X, Chen MS, Clayton S, Collins AT, Cortes J, Costello R, Dalerba P, Diehn M, Dou J, Dylla SJ, Eyler CE, Fischer S, Garvalov BK, Ghiaur G, Gibbs CP, Gilbert CA, H. Niess, Haferlach T, Hochhaus A, Hosen N, Huff CA, Hurwitz H, Jiang X, Jones RJ, Jones RJ, Jones RJ, Ju Z, K.-W. Jauch, Kanamori M, Kiladjian JJ, Klonisch T, Kojima T, Korpal M, L. Zhao, Li C, Liu G, Liu R, Liu S, Lonardo E, Mauro MJ, McDermott SP, Merante S, Mimeault M, Moserle L, O’Brien SG, Park CY, Phillips TM, Platet N, Q. Bao, Rasheed ZA, Reya T, Reya T, Richardson GD, Roeder I, Seidel S, Singh A, Singh SK, Strojnik T, Stupp R, Suh MR, Szotek PP, Tang C, Tang M, Todaro M, Tu LC, Vermeulen L, Wilson BJ, Wright MH, Xu N, Y. Zhao, Yu F, Zhao C, Zhou BB   +82 more
core   +1 more source

Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway

Cell Communication and Signaling, 2019
Endometriosis, characterized by the presence of functional endometrial tissues outside the uterus, is one of the most common gynecological disorders.
Zhenzhen Zhang, Jing Wang, Yabing Chen, Luxuan Suo, Huixian Chen, Li Zhu, G. Wan, Xiaodong Han   +7 more
semanticscholar   +1 more source

Potential role of kisspeptin in the estradiol-induced modulation of inhibin subunit gene expression: Insights from in vivo rat models and hypothalamic cell models

Endocrine Journal
The hypothalamic-pituitary-gonadal (HPG) axis is primarily regulated by kisspeptin neurons. In addition, activin and inhibin within the central nervous system might contribute to the regulation of the HPG axis because they are expressed near kisspeptin ...
Tuvshintugs Tumurbaatar, Haruhiko Kanasaki, Zhuoma Cairang, Batjargal Lkhagvajav, Aki Oride, Hiroe Okada, Satoru Kyo   +6 more
doaj   +1 more source