PPAR Research, 2013 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) and activin are implicated in the control of apoptosis, cell proliferation, and inflammation in cells. We examined both the mechanism by which 15d-PGJ2 regulates the transcription of activin-induced activin ...
Seung-Won Park +5 more
doaj +1 more source
A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling
Cellular & Molecular Biology Letters, 2023 Background TGFβ1 is a major profibrotic mediator in chronic kidney disease (CKD). Its direct inhibition, however, is limited by adverse effects. Inhibition of activins, also members of the TGFβ superfamily, blocks TGFβ1 profibrotic effects, but the ...
Asfia Soomro +8 more
doaj +1 more source
Activin B antagonizes RhoA signaling to stimulate mesenchymal morphology and invasiveness of clear cell renal cell carcinomas. [PDF]
PLoS ONE, 2014 Activin B belongs to the TGFβ family of growth factors and is upregulated in clear cell renal cell carcinoma cells by hypoxia inducible factors. Expression of Activin B is required for tumor growth in vivo and tumor cell invasion in vitro.
Ingrid Wacker, Jürgen Behrens
doaj +1 more source
Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. [PDF]
, 2015 The field of tissue engineering entered a new era with the development of human pluripotent stem cells (hPSCs), which are capable of unlimited expansion whilst retaining the potential to differentiate into all mature cell populations.
Brafman, David +8 more
core +3 more sources
The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts
Arthritis Research & Therapy, 2019 Background Activin A and follistatin exhibit immunomodulatory functions, thus affecting autoinflammatory processes as found in rheumatoid arthritis (RA).
Magnus Diller +11 more
doaj +1 more source
Activin in the brain modulates anxiety-related behavior and adult neurogenesis. [PDF]
PLoS ONE, 2008 Activin, a member of the transforming growth factor-beta superfamily, is an endocrine hormone that regulates differentiation and proliferation of a wide variety of cells. In the brain, activin protects neurons from ischemic damage.
Hiroshi Ageta +6 more
doaj +1 more source
Gene expression and protein localisation for activin-A, follistatin and activin receptors in goat ovaries [PDF]
Journal of Endocrinology, 2004 We studied the protein and mRNA expression of activin-A, follistatin and activin receptors in goat ovaries to find evidence of their possible role in ovarian activity, particularly in the various stages of follicle development. Ovaries of cyclic goats were collected and then either fixed in paraformaldehyde for immunohistochemical localisation of ...
Silva, J.R.V. +4 more
openaire +2 more sources
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
The specificities of small molecule inhibitors of the TGF beta and BMP pathways [PDF]
, 2011 Small molecule inhibitors of type 1 receptor serine threonine kinases (ALKs1-7), the mediators of TGF beta and BMP signals, have been employed extensively to assess their physiological roles in cells and organisms. While all of these inhibitors have been
Sapkota, Gopal P. +2 more
core +3 more sources
Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss
iMetaMed, EarlyView.As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu +6 more
wiley +1 more source