Results 141 to 150 of about 21,210,719 (287)

Functional Analysis of Mature Activin A Produced by Enterokinase in Plant Cells

Rice
Molecular farming for producing biopharmaceuticals in plants is considered an excellent method to replace some of the production methods currently used, and a significant number of recombinant proteins have already shown the potential to facilitate this.
Ki-Beom Moon, Ji-Sun Park, Han-Gyeul Kim, Jae-Heung Jeon, Tae-Ho Kwon, Kyung-Sook Chung, Hyo-Jun Lee, Hyun-Soon Kim   +7 more
doaj   +1 more source

Challenges and possible clinical applications of human embryonic stem cell research [PDF]

, 2012
Human embryonic stem cells (hESC) are harvested from the inner cell mass of the pre-implantation embryo and possess several unique characteristics. First, they are self-renewing, meaning they can grow indefinitely in an appropriate culture environment ...
De Sutter, Petra, Heindryckx, Björn, O'Leary, Thomas, Van der Jeught, Margot   +3 more
core   +1 more source

Intertwining of Activin A and TGFβ Signaling: Dual Roles in Cancer Progression and Cancer Cell Invasion

Cancers, 2014
In recent years, a significant amount of research has examined the controversial role of activin A in cancer. Activin A, a member of the transforming growth factor β (TGFβ) superfamily, is best characterized for its function during embryogenesis in ...
Holli A. Loomans, C. Andl
semanticscholar   +1 more source

Oral Immunotherapy Induces Shift in lncRNA Expression Modulating Allergen‐Specific Immune Responses

Allergy, EarlyView.
We used PBMC transcriptome from 50 hen's egg‐allergic patients to study the role of lncRNA in OIT. Positive correlation was found between 17 lncRNAs and the IL‐4/IL‐13 pathway in vivo, and the expression of the selected lncRNA aligned with CXCL8 upon PBMC egg‐restimulation.
Olivia Liong, Kati Palosuo, Victoria Hinkkanen, Vittorio Fortino, Mika J. Mäkelä, Piia Karisola   +5 more
wiley   +1 more source

Activin A plays an essential role in migration and proliferation of hepatic stellate cells via Smad3 and calcium signaling

Scientific Reports
Activin A and hepatic stellate cells (HSCs) are involved in tissue repair and fibrosis in liver injury. This study investigated the impact of activin A on HSC activation and migration.
Wei Zhang, Linjing Zhu, Fang Fang, Fenglin Zhang, Runnan Wang, Ke Yang, Yahui Liu, Xueling Cui   +7 more
doaj   +1 more source

Acute Modulation of Synaptic Plasticity of Pyramidal Neurons by Activin in Adult Hippocampus

Frontiers in Neural Circuits, 2014
Activin A is known as a neuroprotective factor produced upon acute excitotoxic injury of the hippocampus (in pathological states). We attempt to reveal the role of activin as a neuromodulator in the adult male hippocampus under physiological conditions ...
Yoshitaka eHasegawa, Hideo eMukai, Hideo eMukai, Hideo eMukai, Hideo eMukai, Makoto eAsashima, Yasushi eHojo, Yasushi eHojo, Yasushi eHojo, Muneki eIkeda, Yoshimasa eKomatsuzaki, Yuuki eOoishi, Suguru eKawato, Suguru eKawato, Suguru eKawato, Suguru eKawato   +15 more
doaj   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Activin A is deeply involved in the progression of sarcopenia and leads to poor prognosis in lung cancer patients

Scientific Reports
Patients with lung cancer frequently develop sarcopenia, which severely affects quality of life. The underlying mechanisms of lung cancer sarcopenia need to be clarified because sarcopenia is strongly correlated with poor prognosis.
Yo Kawaguchi, Yoko Kataoka, Keigo Okamoto, Makoto Yoden, Takuya Shiratori, Ryosuke Kaku, Keiko Ueda, Yasuhiko Ohshio, Tomoya Terashima, Jun Hanaoka   +9 more
doaj   +1 more source

Elevated serum Activin A in chronic obstructive pulmonary disease with skeletal muscle wasting

Clinics
OBJECTIVE: Muscle wasting contributes to the reduced quality of life and increased mortality in chronic obstructive pulmonary disease (COPD). Muscle atrophy in mice with cachexia was caused by Activin A binding to ActRIIB. The role of circulating Activin
Guanghui Zhou, Xianhua Gui, Ruhua Chen, Xingli Fu, Xiuhai Ji, Hui Ding   +5 more
doaj   +1 more source

When, which and how to switch: Navigating JAK inhibitors in myelofibrosis

British Journal of Haematology, EarlyView.
Navigating choice of JAK inhibitor (JAKi) therapy for patients with myelofibrosis who are JAKi‐naïve and for those who have previously been treated with a JAKi.
Jennifer O'Sullivan, Imran Omerdeen, Bethan Psaila   +2 more
wiley   +1 more source