Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer
Biomedicines, 2021 Activin, a member of the TGF-β superfamily, is involved in many physiological processes, such as embryonic development and follicle development, as well as in multiple human diseases including cancer.
Wanglong Qiu +3 more
doaj +1 more source
Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes [PDF]
, 2013 Background Activin A is a pleiotrophic regulatory cytokine, the ablation of which is neonatal lethal. Healthy human alveolar macrophages (AMs) constitutively express activin A, but AMs of patients with pulmonary alveolar proteinosis (PAP) are ...
Barna, Barbara P +6 more
core +1 more source
Effect of Activin A on In Vitro Development of Rat Preantral Follicles and Localization of Activin A and Activin Receptor II [PDF]
Biology of Reproduction, 2001 Preantral follicles (140-160 microm) were isolated mechanically from the ovaries of 10-day-old rats and cultured in groups of four to six for 6 days in medium containing 0, 1, 10, or 100 ng/ml of activin A. Activin stimulated (P < 0.05) the growth of preantral follicles in a dose-dependent fashion and enhanced the proliferation of preantral, oocyte ...
Yu-Zhao, J. +4 more
openaire +3 more sources
Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells [PDF]
, 1997 To gain more insight in the mechanism of action of inhibin, we studied the effect of inhibin on activin signaling in Chinese hamster ovary cells.
Jong, F.H. (Frank) de +6 more
core +3 more sources
Activin A more prominently regulates muscle mass in primates than does GDF8
Nature Communications, 2017 Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative regulator of skeletal muscle mass. GDF8 inhibition results in prominent muscle growth in mice, but less impressive hypertrophy in primates, including man.
E. Latres +18 more
semanticscholar +1 more source
Systemic activation of activin A signaling causes chronic kidney disease-mineral bone disorder [PDF]
, 2018 The high cardiovascular mortality associated with chronic kidney disease (CKD) is caused in part by the CKD-mineral bone disorder (CKD-MBD) syndrome.
Sugatani, Toshifumi
core +2 more sources
Science Translational Medicine, 2019 BV-265, a BMP-2/BMP-6/activin A chimera, delivered in a composite matrix generates bone repair in nonhuman primates at lower concentrations than BMP-2.
H. Seeherman +18 more
semanticscholar +1 more source
Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [PDF]
, 2006 The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its essential role in maintaining pluripotency, Oct4 expression is
Adjaye, J. +8 more
core +2 more sources
N-myc Down-Regulates Activin A
Biochemical and Biophysical Research Communications, 2000 N-myc oncogene amplification is frequent in human neuroblastoma and predicts poor prognosis, but the molecular consequences have remained obscure. We report here that enhanced N-myc expression correlates with low or undetectable expression of activin A, but not other closely related members of the transforming growth factor-beta superfamily.
Breit, Stephen +3 more
openaire +4 more sources
Activin A and pathologies of pregnancy: a review
Placenta, 2023 Activin A is a two-subunit protein belonging to the transforming growth factor β superfamily. First discovered almost three decades ago, it has since been implicated in diverse physiological roles, ranging from wound repair to reproduction. After 30 years of research, altered activin A levels are now understood to be associated with the development of ...
Courtney V. Barber +5 more
openaire +2 more sources