Journal of Cachexia, Sarcopenia and Muscle, 2019 Background Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous activin causes cachexia in mice.
Xiaoling Zhong +16 more
doaj +1 more source
Acute Intermittent Hypoxia Exerts Beneficial Effects and Promotes Repair in Male Mice in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. [PDF]
GliaAcute intermittent hypoxia is a novel, noninvasive therapy that shows promising and similar beneficial repair and remyelination following demyelination in male experimental autoimmune encephalomyelitis, as was previously shown in female mice. ABSTRACT Multiple sclerosis (MS) affects women more frequently than men, but the disease progresses more ...
Tokarska N +6 more
europepmc +2 more sources
Human activin-A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells [PDF]
, 1999 Activin is a member of the transforming growth factor-beta superfamily, and it modulates the proliferation and differentiation of various target cells. In this study, we investigated the role of activin in the initiation and progression
Achterberg, T.A.E. (Tanja) van +6 more
core +3 more sources
Frontiers in Endocrinology, 2023 Correct fetal testis development underpins adult male fertility, and TGFβ superfamily ligands control key aspects of this process. Transcripts encoding one such ligand, activin A, are upregulated in testes after sex determination and remain high until ...
Penny A. F. Whiley +6 more
doaj +1 more source
Enhanced differentiation of human embryonic stem cells towards definitive endoderm on ultrahigh aspect ratio nanopillars [PDF]
, 2015 Differentiation of human embryonic stem cells is widely studied as a potential unlimited source for cell replacement therapy to treat degenerative diseases such as diabetes.
Dufva, Martin +6 more
core +2 more sources
Comparison of bioactivities, binding properties and intra-follicular levels of bovine follistatins [PDF]
, 2015 Five isoforms of follistatin (FST) (Mr 31, 33, 35, 37, 41kDa) were purified from bovine follicular fluid (bFF). Comparison of their activin- and heparan sulphate proteoglycan (HSP)-binding properties and bio-potencies in neutralization of activin-A ...
Boland, Maurice P. +4 more
core +1 more source
Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential [PDF]
, 2013 Human embryonic stem cells (hESCs) are more similar to primed mouse epiblast stem cells (mEpiSCs). mEpiSCs, which are derived in Activin A, show an increased propensity to form primordial germ cell (PGC)-like cells in response to bone morphogenic protein
Chuva de Sousa Lopes, Susana Marina +10 more
core +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Activin A, a member of the transforming growth factor-beta (TGF-β) superfamily, contributes to tissue healing and fibrosis. As the innate tissue cells, fibroblasts also play an important role in wound healing and fibrosis. Herein, this study was aimed to
Lingling Jiang +8 more
doaj +1 more source
Therapeutic blockade of activin-A improves NK cell function and antitumor immunity
Science Signaling, 2019 Activin-A inhibits NK cell effector functions and suppresses antimelanoma immunity. Enhancing NK cells Natural killer (NK) cells are innate immune cells with a critical role in antitumor immunity.
J. Rautela +16 more
semanticscholar +1 more source
Myostatin/Activin-A Signaling in the Vessel Wall and Vascular Calcification
Cells, 2021 A current hypothesis is that transforming growth factor-β signaling ligands, such as activin-A and myostatin, play a role in vascular damage in atherosclerosis and chronic kidney disease (CKD).
Pasquale Esposito +5 more
doaj +1 more source