Results 131 to 140 of about 8,029 (232)

UBE3A Inhibits Trophoblast Cell Migration and Invasion by Promoting ITGB1 Degradation and Affecting PI3K/AKT Signaling

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 4, April 2026.
ABSTRACT Preeclampsia (PE) is an obstetric disease that is characterized by reduced migration and invasion of placental trophoblast cells. Here, the effects of the E3 ubiquitin ligase UBE3A on the migration and invasion of trophoblast cells were evaluated.
Xiu‐Jun Li, Ning Wang, Fan Jiang, Jie‐Cheng Yang, Yan‐Yun Wang, Kun Wang   +5 more
wiley   +1 more source

Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development. [PDF]

, 2010
Signaling mechanisms mediated by the Transforming Growth Factor-beta (TGF-beta) superfamily regulate a variety of developmental processes. Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-beta/activin ...
Lee, Amie Y, Long, Jason E, Maira, Mario, Rubenstein, John LR, Stifani, Stefano   +4 more
core  

Liver Steatosis in Induced Hepatocytes From Carriers of Spinal Muscular Atrophy

Muscle &Nerve, Volume 73, Issue 4, Page 675-682, April 2026.
ABSTRACT Introduction/Aims Although classically characterized as a motor neuron disease, spinal muscular atrophy (SMA) is increasingly recognized as a multisystem disorder. We previously showed hepatocyte‐intrinsic steatosis in SMA, raising the question of whether SMA carriers, who are typically asymptomatic, may also exhibit subclinical hepatic ...
Lingyu Sun, Damien Meng Kiat Leow, Loo Chien Wang, Michelle Yating Eio, Hiromi W. L. Koh, Zi Jian Khong, Gunaseelan Narayanan, Aloysius Kai Soon Teo, Richard Giadone, Radoslaw M. Sobota, Shi Yan Ng, Adrian Kee Keong Teo, Wei Yi Ong, Lee L. Rubin, Basil T. Darras, Crystal J. J. Yeo   +15 more
wiley   +1 more source

The Interplay Between IL‐6, Hepcidin, and BMPR2 Signalling in Pulmonary Arterial Hypertension: Mechanistic Insights Into Vascular Remodelling

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT Pulmonary arterial hypertension (PAH) is characterized by excessive pulmonary vasoconstriction and vascular remodelling, with mutations in bone morphogenetic protein receptor type 2 (BMPR2) being the most common genetic alteration associated with the disease.
Quezia K. Toe, Theo Issitt, Gregory J. Quinlan, S. John Wort   +3 more
wiley   +1 more source

Interplay between ALK2R206H mutant receptor and autophagy signaling regulates receptor stability and its chondrogenic functions

Cell Death Discovery
Heterozygous mutations in the Bone morphogenetic protein (BMP) type I receptor ACVR1, encoding activin-like kinase 2 (ALK2), underlie all cases of the rare genetic musculoskeletal disorder Fibrodysplasia Ossificans Progressiva (FOP).
Laura Coculo, Marius Wits, Irene Mariani, Giulia Fianco, Serena Cappato, Renata Bocciardi, Nicoletta Pedemonte, Elisabetta Volpe, Serena Ciolfi, Rosario Luigi Sessa, Serena Rinaldo, Francesca Cutruzzolà, Daniela Trisciuoglio, Marie-Josè Goumans, Gonzalo Sanchez-Duffhues, Venturina Stagni   +15 more
doaj   +1 more source

Role of inhibin and activin in the modulation of gonadotropin- and steroid-induced oocyte maturation in the teleost Fundulus heteroclitus [PDF]

, 2007
Teresa R Petrino, Gesulla Toussaint, Yu-Wai P Lin   +2 more
core   +1 more source

Lifesaving Compassionate‐Use of Sotatercept in a 12‐Year‐old With Idiopathic Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT Pediatric idiopathic pulmonary arterial hypertension (IPAH) refractory to maximal medical therapy is associated with high morbidity and mortality, and therapeutic options remain limited. We describe a 12‐year‐old girl with end‐stage IPAH who developed acute decompensated right heart failure despite triple combination therapy, including high ...
Weronika Pelczar‐Płachta, Rafał Surmacz, Waldemar Bobkowski   +2 more
wiley   +1 more source

Nintedanib Lacks Efficacy in a Spirometry‐Confirmed and Bleomycin‐Induced Mouse Model of Idiopathic Pulmonary Fibrosis

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Nintedanib, a multitargeted tyrosine kinase inhibitor, is approved for idiopathic pulmonary fibrosis (IPF) for its ability to slow lung function decline. This study systematically evaluated the effects of nintedanib across three independent treatment intervention studies in the single‐dose bleomycin (BLEO) mouse model of IPF.
Jamal Bousamaki, Grzegorz Maciag, Asbjørn Graver Petersen, Stefanie H. Korntner, Stine Marie Jansen, Susanne E. Pors, Linn Salto Mamsen, Silas A. Rasmussen, Casper Gravesen Salinas, Louise Humle Kruse, Michael Feigh, Ulf Simonsen, Henrik H. Hansen   +12 more
wiley   +1 more source

Melanoma cells secrete follistatin, an antagonist of activin-mediated growth inhibition [PDF]

, 2004
Bracke, Marc, Devreese, Bart, Mareel, Marcus, Stove, Christophe, Van Beeumen, Jozef, Vanrobaeys, Frank   +5 more
core   +2 more sources

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, Volume 59, Issue 4, April 2026.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source