Results 1 to 10 of about 51,515 (263)

Regulatory effects of protein S-acylation on insulin secretion and insulin action [PDF]

Open Biology, 2021
Post-translational modifications (PTMs) such as phosphorylation and ubiquitination are well-studied events with a recognized importance in all aspects of cellular function.
Luke H. Chamberlain, Michael J. Shipston, Gwyn W. Gould   +2 more
doaj   +2 more sources

Protein acylation in inflammatory diseases: from mechanisms to therapeutic strategies [PDF]

Cell Communication and Signaling
Protein acylation, a critical subset of post-translational modifications (PTMs), serves as a dynamic regulatory mechanism linking cellular metabolism, epigenetic regulation, and inflammatory responses.
Jiayi Ding, Huiyi Wang, Zhengkun Yang, Xiaoxuan Wang, Zhengguo Cao   +4 more
doaj   +2 more sources

Oleate activates PLD2 lipase and GEF activity by modulating membrane microdomain dynamics via S-acylation [PDF]

Journal of Lipid Research
Phospholipase D2 (PLD2) plays critical roles in cellular signaling, membrane dynamics, and cancer progression. Oleate (OA) has been shown to activate PLD2 and promote triple-negative breast cancer (TNBC) cell migration, but the underlying molecular ...
Zhiqiang Guo, Karl-Frédérik Bergeron, Catherine Mounier   +2 more
doaj   +2 more sources

Improvement of plant resistance to geminiviruses via protein de-S-acylation [PDF]

Stress Biology
Geminiviruses are an important group of viruses that infect a variety of plants and result in heavy agricultural losses worldwide. The homologs of C4 (or L4) in monopartite geminiviruses and AC4 (or AL4) in bipartite geminiviruses are critical viral ...
Yawen Zhao, Zhenggang Li, Zhiying Wang, Liting Huang, Gongda Li, Xiaoshi Liu, Meiqi Yuan, Wei Huang, Lishan Ling, Chengwei Yang, Zifu He, Jianbin Lai   +11 more
doaj   +2 more sources

Protein S-acyltransferases and acyl protein thioesterases, regulation executors of protein S-acylation in plants

Frontiers in Plant Science, 2022
Protein S-acylation, also known as palmitoylation, is an important lipid post-translational modification of proteins in eukaryotes. S-acylation plays critical roles in a variety of protein functions involved in plant development and responses to abiotic ...
Jincheng Li, Manqi Zhang, Lijuan Zhou
doaj   +1 more source

Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function

Frontiers in Cell and Developmental Biology, 2021
Post-translational acylation of lysine side chains is a common mechanism of protein regulation. Modification by long-chain fatty acyl groups is an understudied form of lysine acylation that has gained increasing attention recently due to the ...
Garrison Komaniecki, Garrison Komaniecki, Hening Lin, Hening Lin, Hening Lin   +4 more
doaj   +1 more source

Enhancement of Stability and Antioxidant Activity of Mulberry Anthocyanins Through Succinic Acid Acylation

Food Technology and Biotechnology, 2022
Research background. Anthocyanins possess valuable health-promoting activities with significant health benefits for humans. However, their instability is a limiting factor for their usage in functional foods and beverages. Experimental approach. In this
Bei Zhang, Xizhi Jiang, Gaiqun Huang, Xiangdong Xin, Thomas Attaribo, Yueyue Zhang, Ning Zhang, Zhongzheng Gui   +7 more
doaj   +1 more source

Redox-neutral C–H acylation of indole with ketene by manganese catalysis

Green Synthesis and Catalysis, 2022
A low-cost manganese-catalyzed oxidant-free selective C–H acylation of indole with ketene is reported. This protocol features mild reaction conditions and good functional group tolerance. The yield is from middle to excellent.
Chengming Wang, Qijing Zhang
doaj   +1 more source

Iron containing di-cationic ionic liquid [DIL]2+[2FeCl4]2− as a highly efficient catalyst for the acylation of alcohols, phenols and amines

Catalysis Communications, 2023
In this study, we describe the synthesis of an efficient catalyst for the acylation of alcohols, phenols, and amines in the presence of 3,3′-(ethane-1,2-diyl)bis(1-methyl-1H-imidazol-3-ium) tetrachloroferrate [DIL]2+[2FeCl4]2− and acetyl chloride ...
Yash Barot, Satyendra Mishra, Vivek Anand, Roli Mishra   +3 more
doaj   +1 more source

Biological functions and therapeutic potential of acylation by histone acetyltransferases

Acta Materia Medica, 2023
Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression.
Nan Li, Clark Hamor, Yahang An, Licheng Zhu, Yusheng Gong, Yukimatsu Toh, Yusong R. Guo   +6 more
doaj   +1 more source