Results 1 to 10 of about 1,578 (184)

rel-2-[4-Chloro-2-[(5R,6R,7S)-6-[5-(4-methoxyphenyl)-3-(2-naphthyl)-3,4-dihydropyrazole-2-carbonyl]-5-methyl-2-oxo-3,5,6,7-tetrahydrothiopyrano[2,3-d]thiazol-7-yl]phenoxy]acetic Acid

Molbank, 2022
The hetero-Diels–Alder reaction is the main synthetic tool for obtaining pharmacological agents with a thiopyrano[2,3-d]thiazole motif. In the present work, an efficient method for the synthesis of pyrazoline-containing thiopyrano[2,3-d]thiazole is ...
Ihor Yushyn, Serhii Holota, Oksana Ivantsiv, Roman Lesyk   +3 more
doaj   +1 more source

Protein acylation in inflammatory diseases: from mechanisms to therapeutic strategies

Cell Communication and Signaling
Protein acylation, a critical subset of post-translational modifications (PTMs), serves as a dynamic regulatory mechanism linking cellular metabolism, epigenetic regulation, and inflammatory responses.
Jiayi Ding, Huiyi Wang, Zhengkun Yang, Xiaoxuan Wang, Zhengguo Cao   +4 more
doaj   +1 more source

Chemical Modification of Pectin and Polygalacturonic Acid: A Critical Review

BioResources, 2021
Pectin, as a sustainable biopolymer with its two complementary functionalities (carboxyl and hydroxyl moieties) imparted in the α-1,4-galacturonic acid repeating unit, has gained increasing attention in the last few years.
Hendryk Würfel, Katja Geitel, Haisong Qi, Thomas Heinze   +3 more
doaj   +1 more source

Oleate activates PLD2 lipase and GEF activity by modulating membrane microdomain dynamics via S-acylation

Journal of Lipid Research
Phospholipase D2 (PLD2) plays critical roles in cellular signaling, membrane dynamics, and cancer progression. Oleate (OA) has been shown to activate PLD2 and promote triple-negative breast cancer (TNBC) cell migration, but the underlying molecular ...
Zhiqiang Guo, Karl-Frédérik Bergeron, Catherine Mounier   +2 more
doaj   +1 more source

Anthocyanin Profiles in Flowers of Grape Hyacinth

Molecules, 2017
Grape hyacinth (Muscari spp.) is a popular ornamental bulbous perennial famous for its blue flowers. To understand the chemical basis of the rich blue colors in this plant, anthocyanin profiles of six blue flowering grape hyacinths as well as one pink ...
Qian Lou, Lin Wang, Hongli Liu, Yali Liu
doaj   +1 more source

Preparation of labeled alkyl acyl glycerophosphorylcholine

Journal of Lipid Research, 1970
A method for the preparation of 1-alkyl 2-acyl glycero-3-phosphorylcholine, labeled in the 2-position with oleic acid-1-14C is described. This method, based on the acylation of a 1-alkyl glycero-3-phosphorylcholine-CdCl2 complex which is, in turn, formed
A. POULOS
doaj   +1 more source

Biocatalytic Synthesis of Novel Partial Esters of a Bioactive Dihydroxy 4-Methylcoumarin by Rhizopus oryzae Lipase (ROL)

Molecules, 2016
Highly regioselective acylation has been observed in 7,8-dihydroxy-4-methylcoumarin (DHMC) by the lipase from Rhizopus oryzae suspended in tetrahydrofuran (THF) at 45 °C using six different acid anhydrides as acylating agents.
Vinod Kumar, Divya Mathur, Smriti Srivastava, Shashwat Malhotra, Neha Rana, Suraj K. Singh, Brajendra K. Singh, Ashok K. Prasad, Anjani J. Varma, Christophe Len, Ramesh C. Kuhad, Rajendra K. Saxena, Virinder S. Parmar   +12 more
doaj   +1 more source

Processes and therapeutic perspectives of acylation modifications of lysine and cysteine in tumors

Cell Communication and Signaling
Acylation modification plays a crucial role in tumor progression through altering protein homeostasis and localization. However, a comprehensive summary of these processes is lacking.
Jialin Jiang, Jiabin Chen, Shuhang Huang, Yue Tian, Lanyu Liu, Jiahui Yao, Yuzhu Zhang, Can Jiang, Xingting Zhang, Na Han, Guang Shu, Gang Yin, Li Xian Yip, Kuoran Xing, David Tai Leong, Maonan Wang   +15 more
doaj   +1 more source

S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

eLife
NLRP3 is an inflammasome seeding pattern recognition receptor activated in response to multiple danger signals which perturb intracellular homeostasis.
Daniel M Williams, Andrew A Peden
doaj   +1 more source

DHHC enzymes in alphavirus glycoprotein acylation: A target for broad-spectrum antiviral therapy

Cell Reports
Summary: Alphaviruses are mosquito-transmitted viruses that cause severe zoonotic diseases. Their envelope glycoproteins, E1 and E2, undergo cysteine acylation, a process critical for virus infection but previously undefined mechanistically.
Xiaoling Li, Chaoyun Han, Wanjie Song, Zhiwen Jiang, Yunbiao Lu, Sainan Wang, Jie Chen, Yu Deng, Andres Merits, Wan-Ting He, Shuo Su, Michael Veit   +11 more
doaj   +1 more source