Results 1 to 10 of about 130,745 (290)

Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function

Frontiers in Cell and Developmental Biology, 2021
Post-translational acylation of lysine side chains is a common mechanism of protein regulation. Modification by long-chain fatty acyl groups is an understudied form of lysine acylation that has gained increasing attention recently due to the ...
Garrison Komaniecki, Garrison Komaniecki, Hening Lin, Hening Lin, Hening Lin   +4 more
doaj   +2 more sources

Sequestering sequestosome 1 via S-acylation in autophagy, Huntington disease, and beyond [PDF]

Autophagy Reports
Protein mislocalization and aggregation are hallmark features in neurodegeneration. As proteins mislocalize, proteostasis deficiency and protein aggregation typically follow.
Y Alshehabi, F Abrar, D.D.O Martin
doaj   +2 more sources

Nuanced differences in adenylate cyclase toxin production, acylation, and secretion may contribute to the evolution of virulence in Bordetella species [PDF]

mBio
Bordetella pertussis, which causes the acute human disease whooping cough, evolved from Bordetella bronchiseptica, which causes long-term, chronic infections in a broad range of mammals. Both B. pertussis and B.
Alexa R. Wolber, Liliana S. McKay, Katlyn B. Mote, Richard M. Johnson, Carol S. Inatsuka, Peggy A. Cotter   +5 more
doaj   +2 more sources

The function and mechanism of protein acylation in the regulation of viral infection [PDF]

Virulence
Protein acylation modification is one of the most important protein post-translational modifications, which regulates the function of the protein by adding acyl groups to the residues of the protein.
Lei Song, Ziang Wei, Pan Shang, Shijie Hu, Lei Chen, Lili Niu, Yan Wang, Mailin Gan, Linyuan Shen, Li Zhu, Ye Zhao   +10 more
doaj   +2 more sources

Regulatory effects of protein S-acylation on insulin secretion and insulin action [PDF]

Open Biology, 2021
Post-translational modifications (PTMs) such as phosphorylation and ubiquitination are well-studied events with a recognized importance in all aspects of cellular function.
Luke H. Chamberlain, Michael J. Shipston, Gwyn W. Gould   +2 more
doaj   +1 more source

Protein S-acyltransferases and acyl protein thioesterases, regulation executors of protein S-acylation in plants

Frontiers in Plant Science, 2022
Protein S-acylation, also known as palmitoylation, is an important lipid post-translational modification of proteins in eukaryotes. S-acylation plays critical roles in a variety of protein functions involved in plant development and responses to abiotic ...
Jincheng Li, Manqi Zhang, Lijuan Zhou
doaj   +1 more source

Enhancement of Stability and Antioxidant Activity of Mulberry Anthocyanins Through Succinic Acid Acylation

Food Technology and Biotechnology, 2022
Research background. Anthocyanins possess valuable health-promoting activities with significant health benefits for humans. However, their instability is a limiting factor for their usage in functional foods and beverages. Experimental approach. In this
Bei Zhang, Xizhi Jiang, Gaiqun Huang, Xiangdong Xin, Thomas Attaribo, Yueyue Zhang, Ning Zhang, Zhongzheng Gui   +7 more
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Redox-neutral C–H acylation of indole with ketene by manganese catalysis

Green Synthesis and Catalysis, 2022
A low-cost manganese-catalyzed oxidant-free selective C–H acylation of indole with ketene is reported. This protocol features mild reaction conditions and good functional group tolerance. The yield is from middle to excellent.
Chengming Wang, Qijing Zhang
doaj   +1 more source

Iron containing di-cationic ionic liquid [DIL]2+[2FeCl4]2− as a highly efficient catalyst for the acylation of alcohols, phenols and amines

Catalysis Communications, 2023
In this study, we describe the synthesis of an efficient catalyst for the acylation of alcohols, phenols, and amines in the presence of 3,3′-(ethane-1,2-diyl)bis(1-methyl-1H-imidazol-3-ium) tetrachloroferrate [DIL]2+[2FeCl4]2− and acetyl chloride ...
Yash Barot, Satyendra Mishra, Vivek Anand, Roli Mishra   +3 more
doaj   +1 more source

Biological functions and therapeutic potential of acylation by histone acetyltransferases

Acta Materia Medica, 2023
Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression.
Nan Li, Clark Hamor, Yahang An, Licheng Zhu, Yusheng Gong, Yukimatsu Toh, Yusong R. Guo   +6 more
doaj   +1 more source